2024
Microglia: The Drunken Gardeners of Early Adversity
Ahmed S, Polis B, Kaffman A. Microglia: The Drunken Gardeners of Early Adversity. Biomolecules 2024, 14: 964. PMID: 39199352, PMCID: PMC11353196, DOI: 10.3390/biom14080964.Peer-Reviewed Original ResearchEarly life adversityAbnormal immune responseImpact of early life adversityHistory of early life adversityRodent studiesImmune responseNegative childhood experiencesConditions in adulthoodLevels of inflammatory cytokinesLong-term alterationsRefractory responses to treatmentAbnormal brain developmentMicroglial functionResponse to treatmentTraumatic brain injuryResident immune cellsStress reactivityEarly adversityLife adversitySubstance useChildhood experiencesMicroglial inflammatory responseImmune cellsIn adulthoodPeriod of development
2017
Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges
Johnson FK, Kaffman A. Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges. Brain Behavior And Immunity 2017, 69: 18-27. PMID: 28625767, PMCID: PMC5732099, DOI: 10.1016/j.bbi.2017.06.008.Peer-Reviewed Original ResearchConceptsEarly life stressMicroglial functionLife stressAnimal modelsBehavioral abnormalitiesStress-induced neuroinflammationMicroglial cell numberFunction of microgliaMicroglial gene expressionChildhood maltreatmentInnate immune systemMedical complicationsLong-term adultAbnormal maturationMouse modelSynaptic pruningRodent brainImmune systemPhagocytic activityAxonal growthBrain developmentDaily separationFirst weekGene expressionAbnormalities
2016
Early life stress perturbs the maturation of microglia in the developing hippocampus
Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behavior And Immunity 2016, 57: 79-93. PMID: 27301858, PMCID: PMC5010940, DOI: 10.1016/j.bbi.2016.06.006.Peer-Reviewed Original ResearchConceptsEarly life stressHippocampal developmentLife stressPhagocytic activityAbnormal hippocampal developmentNormal hippocampal developmentMorphology of microgliaPostnatal day 28Vivo phagocytic activityImpairs hippocampal functionMaturation of microgliaImmune panelHippocampal microgliaMicroglial activityMicroglial functionNormal cell numbersSynaptic maturationOld miceMicrogliaMouse modelRodent modelsSynaptic pruningDay 28Old pupsHippocampus