2023
Rethinking Cartilage Lesions of the Ankle: An Update on the Role of Biologic Adjuvants
Gianakos A, Kennedy J. Rethinking Cartilage Lesions of the Ankle: An Update on the Role of Biologic Adjuvants. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 701-707. PMID: 37026780, DOI: 10.5435/jaaos-d-22-01042.Peer-Reviewed Original ResearchAdvances in Cartilage Repair
Azam M, Butler J, Duenes M, McAllister T, Walls R, Gianakos A, Kennedy J. Advances in Cartilage Repair. Orthopedic Clinics Of North America 2023, 54: 227-236. PMID: 36894294, DOI: 10.1016/j.ocl.2022.11.007.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationBone marrow stimulationPoor healing capacityAnkle painUncontained lesionsConservative managementArthroscopic debridementCystic lesionsBiological adjuvantsTraumatic etiologyOsteochondral transplantationInvasive proceduresOsteochondral lesionsLarge lesionsMarrow stimulationAnkle jointLesionsSmall lesionsScaffold-based therapiesHealing capacityPatientsArticular cartilageUnsatisfactory resultsCartilage repairDebridement
2022
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role?
Gianakos A, Okedele O, Mulcahey M, Kerkhoffs G, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role? The Journal Of Foot & Ankle Surgery 2022, 62: 96-101. PMID: 35753861, DOI: 10.1053/j.jfas.2022.05.005.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationFemale patientsOsteochondral lesionsMale patientsOsteochondral transplantationPotential gender-related differencesCartilage repair tissue (MOCART) scoreMean MOCART scoreAnkle Outcome ScoreMechanism of injuryChronic ankle instabilityTalar osteochondral lesionsGender-related differencesMean FAOSConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMOCART scoreAnkle instabilityPatientsDemographic dataTissue scoresLesionsRehabilitation strategiesGender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus
Gianakos A, Williamson E, Mercer N, Kerkhoffs G, Kennedy J. Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus. The Journal Of Foot & Ankle Surgery 2022, 62: 75-79. PMID: 35659478, DOI: 10.1053/j.jfas.2022.04.010.Peer-Reviewed Original ResearchConceptsBone marrow stimulationMale patientsFemale patientsPain scoresOsteochondral lesionsMarrow stimulationCartilage repair tissue (MOCART) scoreSymptomatic osteochondral lesionsAnkle Outcome ScoreShort Form-12Mechanism of injuryMagnetic resonance observationYears postsurgeryClinical outcomesOutcome scoresSurgical outcomesRetrospective analysisAnkle biomechanicsPatientsMedial lesionsLateral lesionsLesionsTissue scoresCartilage morphologyOutcomesTerminology for osteochondral lesions of the ankle: proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle
Murawski C, Jamal M, Hurley E, Buda R, Hunt K, McCollum G, Paul J, Vannini F, Walther M, Yasui Y, Ali Z, Altink J, Batista J, Bayer S, Berlet G, Calder J, Dahmen J, Davey M, D'Hooghe P, DiGiovanni C, Ferkel R, Gianakos A, Giza E, Glazebrook M, Hangody L, Haverkamp D, Hintermann B, Hua Y, Hurley D, Karlsson J, Kearns S, Kennedy J, Kerkhoffs G, Lambers K, Lee J, Mercer N, Mulvin C, Nunley J, Pearce C, Pereira H, Prado M, Raikin S, Savage-Elliott I, Schon L, Shimozono Y, Stone J, Stufkens S, Sullivan M, Takao M, Thermann H, Thordarson D, Toale J, Valderrabano V, van Bergen C, van Dijk C, Walls R, Younger A, Hogan M. Terminology for osteochondral lesions of the ankle: proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Journal Of ISAKOS Joint Disorders & Orthopaedic Sports Medicine 2022, 7: 62-66. PMID: 35546437, DOI: 10.1016/j.jisako.2021.12.001.Peer-Reviewed Original Research
2020
Autologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population
Seow D, Shimozono Y, Gianakos A, Chiarello E, Mercer N, Hurley E, Kennedy J. Autologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population. Knee Surgery, Sports Traumatology, Arthroscopy 2020, 29: 1554-1561. PMID: 32856096, DOI: 10.1007/s00167-020-06216-w.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationQuality of evidenceOLT sizeRehabilitation protocolOsteochondral transplantationAthletic populationOsteochondral lesionsSystematic reviewPre-injury statusCochrane Library databasesLevel of evidencePredictors of returnSpecific eligibility criteriaHigh rateFixed-effects modelLevel IVSurgeons' protocolsLibrary databasesPRISMA guidelinesEligibility criteriaSubsequent rehabilitationIncrease ageMean timeSignificant correlationTransplantation
2016
The Effect of Different Bone Marrow Stimulation Techniques on Human Talar Subchondral Bone: A Micro–Computed Tomography Evaluation
Gianakos A, Yasui Y, Fraser E, Ross K, Prado M, Fortier L, Kennedy J. The Effect of Different Bone Marrow Stimulation Techniques on Human Talar Subchondral Bone: A Micro–Computed Tomography Evaluation. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2016, 32: 2110-2117. PMID: 27234650, DOI: 10.1016/j.arthro.2016.03.028.Peer-Reviewed Original ResearchConceptsBone marrow stimulation techniquesMarrow stimulation techniquesSubchondral boneK-wiresMicrofracture awlBone surface area/bone volumeBone volume/total tissue volumeStimulation techniquesBone marrow compartmentTotal tissue volumeBone volume fractionTomography evaluationMicro-computed tomography analysisTrabecular numberBone marrowBone volumeMarrow compartmentSclerosisTrabecular thicknessGrade 1Trabecular compactionBone holeLarger diameter devicesTissue areaTissue volume