The Efficacy of Bisphosphonates with Core Decompression and Mesenchymal Stem Cells Compared with Bisphosphonates Alone in the Treatment of Osteonecrosis of the Hip: A Retrospective Study
Gianakos A, Moya-Angeler J, Duggal S, Zambrana L, Fields K, Mintz D, Cornell C, Lane J. The Efficacy of Bisphosphonates with Core Decompression and Mesenchymal Stem Cells Compared with Bisphosphonates Alone in the Treatment of Osteonecrosis of the Hip: A Retrospective Study. HSS Journal ® 2016, 12: 137-144. PMID: 27385942, PMCID: PMC4916091, DOI: 10.1007/s11420-016-9487-7.Peer-Reviewed Original ResearchModified Harris Hip ScoreVisual analogue scoreTotal hip arthroplastyBisphosphonate therapyCore decompressionMesenchymal stem cellsFunctional outcomeTreatment groupsHip replacementFemoral headEfficacy of bisphosphonatesFicat stage IRadiologic outcome measuresHarris hip scoreYear of diagnosisTreatment of osteonecrosisFuture prospective studiesEarly-stage ONFHInclusion/exclusion criteriaStem cellsJoint preserving proceduresTotal hip replacementProgression of collapseFicat stageInstitution's registryBone Marrow Aspirate Concentrate in Animal Long Bone Healing
Gianakos A, Ni A, Zambrana L, Kennedy J, Lane J. Bone Marrow Aspirate Concentrate in Animal Long Bone Healing. Journal Of Orthopaedic Trauma 2016, 30: 1-9. PMID: 26371620, DOI: 10.1097/bot.0000000000000453.Peer-Reviewed Original ResearchConceptsBone marrow aspirate concentrateBone healingLong bone healingBone mesenchymal stem cellsUse of BMACConfer beneficial effectsLong bone fracturesPubMed/MEDLINESegmental defectsSignificant increaseEarly bone healingBMAC groupEmbase databasesComputed tomographyBone fracturesHistomorphometric assessmentMesenchymal stem cellsBone areaBeneficial effectsVivo evidenceBone formationVivo studiesLong bonesConfidence intervalsHealingCurrent Status of Adipose-Derived Mesenchymal Stem Cells in Cartilage Repair
Gianakos A, Kennedy J. Current Status of Adipose-Derived Mesenchymal Stem Cells in Cartilage Repair. Journal Of Tissue Science & Engineering 2016, 7 DOI: 10.4172/2157-7552.1000177.Peer-Reviewed Original ResearchAdipose-derived mesenchymal stem cellsMesenchymal stem cellsStromal vascular fractionCartilaginous injuriesStem cellsDonor site morbidityBone marrow mesenchymal stem cellsMarrow mesenchymal stem cellsAdjunctive treatmentCartilage repairFuture clinical applicationsCartilage damageClinical successAdipose tissueSite morbidityVascular fractionClinical useLack of standardizationClinical applicationCell numberInjuryTreatmentLow cell numbersConfusing terminologyCells