2016
Treatment of Pre-Collapse Stages of Osteonecrosis of the Femoral Head: a Systematic Review of Randomized Control Trials
Villa J, Husain S, van der List J, Gianakos A, Lane J. Treatment of Pre-Collapse Stages of Osteonecrosis of the Femoral Head: a Systematic Review of Randomized Control Trials. HSS Journal ® 2016, 12: 261-271. PMID: 27703421, PMCID: PMC5026659, DOI: 10.1007/s11420-016-9505-9.Peer-Reviewed Original ResearchRandomized clinical trialsFemoral head collapseBone marrow mesenchymal cellsCore decompressionPre-collapse ONFHHead collapseLower riskFemoral headSystematic reviewLow-level evidence studiesMore RCTsQuestions/PurposesThe purposeNew combination therapiesMeta-Analyses (PRISMA) guidelinesRandomized control trialStandardized outcome measuresPreferred Reporting ItemsPre-collapse stageMethodsUsing PubMedRadiologic outcomesBisphosphonate treatmentClinical evidenceMarrow mesenchymal cellsCombination therapyFunctional outcome
2015
Bisphosphonate Treatment in Osteoporosis: Optimal Duration of Therapy and the Incorporation of a Drug Holiday
Villa J, Gianakos A, Lane J. Bisphosphonate Treatment in Osteoporosis: Optimal Duration of Therapy and the Incorporation of a Drug Holiday. HSS Journal ® 2015, 12: 66-73. PMID: 26855630, PMCID: PMC4733702, DOI: 10.1007/s11420-015-9469-1.Peer-Reviewed Original ResearchRecent fragility fractureDrug holidayBisphosphonate treatmentFragility fracturesBone deficiencyQuestions/PurposesThe purposeHigh fracture riskBone turnover rateRisk of fractureBone mass measurementsBisphosphonate therapyDrug discontinuationPeer-reviewed journalsCase seriesDrug therapyFracture riskPurposesThe purposeClinical trialsInclusion criteriaCase controlExclusion criteriaMethodsA reviewHuman studiesPatientsElectronic databases