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Titles
Research Scientist of Surgery
Departments & Organizations
Education & Training
- Post Doctoral Fellow
- The Johns Hopkins University
- PhD
- University of Melbourne
Research
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Overview
My research focuses on a better understanding of epigenetic mechanisms pertaining to Pancreatic Cancer initiation and progression. I am also developing novel liquid biopsy-based technologies to analyze cell-free DNA in early cancer detection and to monitor therapeutic responses to chemotherapy.
I am also interested in the disparities in cancer outcomes with a special focus on the implications of racial diversity in the molecular landscape of pancreatic cancer.
Research at a Glance
Yale Co-Authors
Frequent collaborators of Anup Sharma's published research.
Publications Timeline
A big-picture view of Anup Sharma's research output by year.
Nita Ahuja, MD, MBA, FACS
John Kunstman, MD, MHS, FACS
Lee Ying
Alyssa Ann Grimshaw, MBA, MLIS, MPH
Ankit Dhiman
Bony De Kumar
Former YSM
11Publications
124Citations
Publications
2026
SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma
Tang H, Sailo B, Shang X, Hossan MS, Kratz J, Das P, Chhoda A, Aldo P, Liu H, Robert ME, Doucette S, Paris TJ, Kunstman JW, Pappou E, Wood LD, Iacobuzio-Donahue CA, Wolfgang CL, Mazzetto M, He L, Pfaff M, Ang-Olson O, Hoggard T, Garcia-Milian R, Sharma A, Levchenko A, Ahuja N. SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma. Cell Reports 2026, 45: 117806. DOI: 10.1016/j.celrep.2026.117806.Peer-Reviewed Original ResearchPrognostic impact of somatic mutations among patients with pleural and peritoneal mesothelioma
Bader JM, Dhiman A, Aguirre N, Ofori KA, Gupta P, Qin H, Sharma A, Mitchell O, Tjota MY, Husain AN, Drazer M, Churpek J, Kindler H, Turaga K. Prognostic impact of somatic mutations among patients with pleural and peritoneal mesothelioma. Npj Precision Oncology 2026 DOI: 10.1038/s41698-026-01495-x.Peer-Reviewed Original ResearchThis study investigates the prognostic impact of somatic mutations in mesothelioma, showing NF2 truncating variants worsen survival, supporting genomic testing to guide treatment strategies.Epigenetic Regulation of Higher-Order Chromatin Structure (HOCS) and Its Implication in Human Diseases
Ladel L, Sailo B, Das P, Lin E, Tan W, Chhoda A, Tang H, Ang-Olson O, He L, John N, Kratz J, Sharma A, Ahuja N. Epigenetic Regulation of Higher-Order Chromatin Structure (HOCS) and Its Implication in Human Diseases. Cancers 2026, 18: 483. PMID: 41681953, PMCID: PMC12897372, DOI: 10.3390/cancers18030483.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2025
Decoding the Epigenome: Comparative Analysis of Uterine Leiomyosarcoma and Leiomyoma
Pfaff M, Costa P, Tang H, Sailo B, Sharma A, Ahuja N. Decoding the Epigenome: Comparative Analysis of Uterine Leiomyosarcoma and Leiomyoma. Cancers 2025, 17: 2610. PMID: 40867239, PMCID: PMC12384543, DOI: 10.3390/cancers17162610.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitations
2024
Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology
Tan W, Nagabhyrava S, Ang-Olson O, Das P, Ladel L, Sailo B, He L, Sharma A, Ahuja N. Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology. Current Issues In Molecular Biology 2024, 46: 6533-6565. PMID: 39057032, PMCID: PMC11276574, DOI: 10.3390/cimb46070390.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricProlonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection
Ying L, Ilagan-Ying Y, Kunstman J, Peters N, Almeida M, Blackburn H, Ferrucci L, Billingsley K, Khan S, Chhoda A, John N, Salem R, Sharma A, Ahuja N. Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection. Surgical Oncology Insight 2024, 1: 100007. DOI: 10.1016/j.soi.2024.100007.Peer-Reviewed Original ResearchCitations
2023
Early Detection of Cancers in the Era of Precision Oncology
Tan W, Sharma A, Das P, Ahuja N. Early Detection of Cancers in the Era of Precision Oncology. Current Opinion In Oncology 2023, 35: 115-124. PMID: 36721896, DOI: 10.1097/cco.0000000000000931.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchCitationsAltmetric
2022
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence
Heumann T, Baretti M, Sugar E, Durham J, Linden S, Lopez-Vidal T, Leatherman J, Cope L, Sharma A, Weekes C, O’Dwyer P, Reiss K, Monga D, Ahuja N, Azad N. A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence. Clinical Epigenetics 2022, 14: 166. PMID: 36463226, PMCID: PMC9719150, DOI: 10.1186/s13148-022-01367-8.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Quantitative assessment of the immune microenvironment in African American Triple Negative Breast Cancer: a case–control study
Yaghoobi V, Moutafi M, Aung TN, Pelekanou V, Yaghoubi S, Blenman K, Ibrahim E, Vathiotis IA, Shafi S, Sharma A, O’Meara T, Fernandez AI, Pusztai L, Rimm DL. Quantitative assessment of the immune microenvironment in African American Triple Negative Breast Cancer: a case–control study. Breast Cancer Research 2021, 23: 113. PMID: 34906209, PMCID: PMC8670126, DOI: 10.1186/s13058-021-01493-w.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Young Investigator Award
04/02/2012International AwardAsian-Pacific Society on Thromb & HemostDetailsAustraliahonor Young Investigator Award
04/01/2011International AwardInternational Society on Thromb & HaemostDetailsJapan
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