2005
Control of the CFTR channel's gates
Vergani P, Basso C, Mense M, Nairn A, Gadsby D. Control of the CFTR channel's gates. Biochemical Society Transactions 2005, 33: 1003-1007. DOI: 10.1042/bst0331003.Peer-Reviewed Original ResearchChannel gateIon channelsProtein family membersNBD dimer interfaceAnion-selective poreEvolutionary conservationABC proteinsCFTR moleculesForm homodimersTransmembrane domainATP bindingHeterodimer interfaceDimer interfaceMolecular mechanismsTight dimerizationNBDATPSingle-channel recordingsResiduesFamily membersNBD1NBD2Cystic fibrosis patientsMutagenesisHomodimerControl of the CFTR channel's gates.
Vergani P, Basso C, Mense M, Nairn A, Gadsby D. Control of the CFTR channel's gates. Biochemical Society Transactions 2005, 33: 1003-7. PMID: 16246032, PMCID: PMC2728124, DOI: 10.1042/bst20051003.Peer-Reviewed Original ResearchConceptsChannel gateIon channelsProtein family membersNBD dimer interfaceAnion-selective poreEvolutionary conservationABC proteinsCFTR moleculesForm homodimersTransmembrane domainATP bindingHeterodimer interfaceDimer interfaceMolecular mechanismsTight dimerizationNBDATPSingle-channel recordingsResiduesFamily membersNBD1NBD2Cystic fibrosis patientsMutagenesisHomodimer
2000
Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
Bibb J, Yan Z, Svenningsson P, Snyder G, Pieribone V, Horiuchi A, Nairn A, Messer A, Greengard P. Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6809-6814. PMID: 10829080, PMCID: PMC18747, DOI: 10.1073/pnas.120166397.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsDisease miceSpiny neuronsStriatal medium spiny neuronsHuntington's diseaseSevere deficiencyHuntington's disease miceHD model miceModel miceDopaminergic neurotransmissionHD miceSelective neurodegenerationHD pathologyMiceDARPP-32DopamineHuman huntingtinBehavioral phenotypesDiseaseNeuronsIon channelsTotal levelsDisease-causing formHuntingtinDeficiency
1992
The role of protein phosphatases in synaptic transmission, plasticity and neuronal development
Nairn A, Shenolikar S. The role of protein phosphatases in synaptic transmission, plasticity and neuronal development. Current Opinion In Neurobiology 1992, 2: 296-301. PMID: 1322750, DOI: 10.1016/0959-4388(92)90118-5.Peer-Reviewed Original ResearchConceptsNeuronal developmentSerine/threonineRole of proteinsProtein phosphataseProtein dephosphorylationMolecular cloningTyrosine proteinIon channelsNervous systemPast year significant advancesNeuronal functionNeurotransmitter receptorsSpecific neuronsProteinSelective inhibitorEnzymeYears significant advancesSynaptic transmissionDephosphorylationCloningThreonineRolePhosphataseRegulationPlasticity
1989
Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes
Bahinski A, Nairn A, Greengard P, Gadsby D. Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature 1989, 340: 718-721. PMID: 2475783, DOI: 10.1038/340718a0.Peer-Reviewed Original ResearchConceptsCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseProtein kinaseChloride ion currentCatalytic subunitRegulatory proteinsKinase activationIon channelsKinaseChloride conductanceCalcium entrySingle-channel currentsCardiac myocytesCellsHeart cellsPhosphorylationAction potential repolarizationConductanceSubunitsProteinIntracellular dialysisMyocytesRegulationChannel currentsAdrenergic stimulation
1985
Calcium-Regulated Protein Phosphorylation in Mammalian Brain
Walaas S, Nairn A. Calcium-Regulated Protein Phosphorylation in Mammalian Brain. 1985, 238-264. DOI: 10.1007/978-3-642-70070-5_12.Peer-Reviewed Original ResearchCentral nervous systemExcitation-secretion couplingNerve cell functionSkeletal muscle contractionPeripheral nervesGeneration of Ca2Nervous systemImportant intracellular messengerMammalian brainNeurotransmitter synthesisMuscle contractionProtein phosphorylationCell functionMammalian tissuesMitochondrial respirationIntracellular messengerEndocytotic phenomenonSecretory glandsIon channelsCa2NerveBrainGlycogenolysis