1992
Distribution of Protein Phosphatase Inhibitor‐1 in Brain and Peripheral Tissues of Various Species: Comparison with DARPP‐32
Hemmings H, Girault J, Nairn A, Bertuzzi G, Greengard P. Distribution of Protein Phosphatase Inhibitor‐1 in Brain and Peripheral Tissues of Various Species: Comparison with DARPP‐32. Journal Of Neurochemistry 1992, 59: 1053-1061. PMID: 1353788, DOI: 10.1111/j.1471-4159.1992.tb08347.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarrier ProteinsCentral Nervous SystemDopamine and cAMP-Regulated Phosphoprotein 32Enzyme InhibitorsFemaleIntracellular Signaling Peptides and ProteinsMaleNerve Tissue ProteinsPhosphoproteinsProteinsRatsRats, Inbred StrainsSubcellular FractionsTissue DistributionTyrosine 3-MonooxygenaseVertebrates
1991
Immunocytochemical localization of phosphatase inhibitor‐1 in rat brain
Gustafson E, Girault J, Hemmings H, Nairn A, Greengard P. Immunocytochemical localization of phosphatase inhibitor‐1 in rat brain. The Journal Of Comparative Neurology 1991, 310: 170-188. PMID: 1955581, DOI: 10.1002/cne.903100204.Peer-Reviewed Original ResearchConceptsPhosphatase inhibitor-1Inhibitor-1Intracellular signal transductionPhosphatase 1Protein phosphorylationSignal transductionWidespread roleNumerous immunoreactive cell bodiesSuprachiasmatic nucleusCyclic AMPImmunocytochemical localizationUse of immunocytochemistrySubstantial populationNeurotransmitter regulationDephosphorylationLocalizationNucleusTransductionImmunocytochemical studyCell bodiesPhosphorylationProteinNeuronsRegulationHigh levels
1989
Multisite phosphorylation of microtubule-associated protein 2 (MAP-2) in rat brain: Peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms
Walaas S, Nairn A. Multisite phosphorylation of microtubule-associated protein 2 (MAP-2) in rat brain: Peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms. Journal Of Molecular Neuroscience 1989, 1: 117-127. DOI: 10.1007/bf02918897.Peer-Reviewed Original ResearchCalcium/phospholipid-dependent protein kinasePhospholipid-dependent protein kinaseCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIProtein kinaseCalcium/calmodulinProtein kinase IIKinase IICyclic AMP-dependent protein kinaseAMP-dependent protein kinaseCommon phosphorylation sitesOnly serine residuesProtein 2Cyclic AMPMultisite phosphorylationThreonine residuesPhosphorylation sitesSerine residuesPhosphorylation systemPhosphorylation mechanismCytoskeletal proteinsMAP-2KinasePeptide mapsDistinct sitesMultisite phosphorylation of microtubule-associated protein 2 (MAP-2) in rat brain: Peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms
Ivar Walaas S, Nairn A. Multisite phosphorylation of microtubule-associated protein 2 (MAP-2) in rat brain: Peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms. Journal Of Molecular Neuroscience 1989, 1: 117-127. PMID: 2561875, DOI: 10.1007/bf02896895.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAmino AcidsAnimalsBrainCalcium-Calmodulin-Dependent Protein KinasesElectrophoresis, Gel, Two-DimensionalElectrophoresis, Polyacrylamide GelMicrotubule-Associated ProteinsOrgan SpecificityPeptide MappingPhosphopeptidesPhosphorylationProtein Kinase CProtein KinasesRatsConceptsCalcium/phospholipid-dependent protein kinasePhospholipid-dependent protein kinaseCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIProtein kinaseCalcium/calmodulinProtein kinase IIKinase IICyclic AMP-dependent protein kinaseAMP-dependent protein kinaseCommon phosphorylation sitesOnly serine residuesProtein 2Cyclic AMPMultisite phosphorylationThreonine residuesPhosphorylation sitesSerine residuesPhosphorylation systemPhosphorylation mechanismCytoskeletal proteinsMAP-2KinasePeptide mapsDistinct sites
1988
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium
Li M, McCann J, Liedtket C, Nairn A, Greengard P, Welsh M. Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature 1988, 331: 358-360. PMID: 2448645, DOI: 10.1038/331358a0.Peer-Reviewed Original ResearchConceptsCAMP-dependent protein kinaseProtein kinaseRegulatory proteinsCl- channelsCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseCommon lethal genetic diseaseNormal cellsLethal genetic diseaseApical Cl- channelsCatalytic subunitCell-free patchesCystic fibrosis airway epitheliaGenetic diseasesVariety of hormonesCF airway epitheliaCF cellsChloride channelsKinaseIntracellular levelsProteinAirway epitheliumCyclic AMPChloride secretionCells
1986
cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones
Paupardin-Tritsch D, Hammond C, Gerschenfeld H, Nairn A, Greengard P. cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones. Nature 1986, 323: 812-814. PMID: 3022154, DOI: 10.1038/323812a0.Peer-Reviewed Original ResearchConceptsIntracellular injectionCyclic GMP-dependent protein kinaseNeuronal membrane permeabilityAbsence of serotoninProtein kinaseSynaptic transmissionNeuronal functionIncrease of Ca2NeuronesCGMP-dependent protein kinaseGMP-dependent protein kinaseSerotoninSnail neuronesCyclic AMPMembrane permeabilityInjectionPhysiological roleProtein phosphorylationCa2CGMPKinase