1999
Zinc Inhibits Protein Synthesis in Neurons POTENTIAL ROLE OF PHOSPHORYLATION OF TRANSLATION INITIATION FACTOR-2α*
Alirezaei M, Nairn A, Glowinski J, Prémont J, Marin P. Zinc Inhibits Protein Synthesis in Neurons POTENTIAL ROLE OF PHOSPHORYLATION OF TRANSLATION INITIATION FACTOR-2α*. Journal Of Biological Chemistry 1999, 274: 32433-32438. PMID: 10542287, DOI: 10.1074/jbc.274.45.32433.Peer-Reviewed Original ResearchConceptsCultured cortical neuronsEukaryotic elongation factor 2Central nervous systemFactor 2Translation initiation factor 2αProtein synthesisCerebral cortexCortical neuronsNervous systemProfound inhibitionSustained increaseBasal levelsTransient increaseBasal ratePotential roleProgressive decreaseInhibits protein synthesisNeuronsAmount of polyribosomesElongation factor 2EIF-2alpha phosphorylationAlpha subunitInhibitionPhosphorylationEukaryotic initiation factor 2
1995
A Role for Calcineurin (Protein Phosphatase-2B) in the Regulation of Glutamate Release
Sihra T, Nairn A, Kloppenburg P, Lin Z, Pouzat C. A Role for Calcineurin (Protein Phosphatase-2B) in the Regulation of Glutamate Release. Biochemical And Biophysical Research Communications 1995, 212: 609-616. PMID: 7542882, DOI: 10.1006/bbrc.1995.2013.Peer-Reviewed Original ResearchConceptsRelease of glutamateGlutamate releaseVoltage-dependent Ca channel activityVoltage-dependent Ca influxRat cerebral cortexCa-dependent componentCa channel activityCerebral cortexNerve terminalsCa influxInflux of CaCa entryActivation of calcineurinCa channelsCalcineurin activityGlutamateFK506CalcineurinRelease