2024
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea.
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionTHE VALUE OF ADJUNCTIVE THERAPIES IN INDIVIDUALS WITH SEVERE OBSTRUCTIVE SLEEP APNEA TREATED WITH HYPOGLOSSAL NERVE STIMULATOR
BUNTAK V, INAYA A, ZINCHUK A. THE VALUE OF ADJUNCTIVE THERAPIES IN INDIVIDUALS WITH SEVERE OBSTRUCTIVE SLEEP APNEA TREATED WITH HYPOGLOSSAL NERVE STIMULATOR. CHEST Journal 2024, 166: a6173. DOI: 10.1016/j.chest.2024.06.3655.Peer-Reviewed Original ResearchThe Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review
Chu Y, Zinchuk A. The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review. Journal Of Clinical Medicine 2024, 13: 1636. PMID: 38541862, PMCID: PMC10970765, DOI: 10.3390/jcm13061636.Peer-Reviewed Original ResearchObstructive sleep apneaObstructive sleep apnea traitsSleep apneaUpper airway collapseHypoglossal nerve stimulationPositive airway pressureTreatment of patientsImpact treatment responseOral appliancesAirway pressureTreatment responseNerve stimulationTherapy modalitiesClinical useHeterogeneous groupApneaNarrative reviewTherapyPrecision careTreatmentPhysiological factorsPatientsPharmacotherapyClinicModalities
2022
Sleep Deficiency in Obstructive Sleep Apnea
Adekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.Peer-Reviewed Original Research
2021
Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes
Ding Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.Peer-Reviewed Original ResearchTreatment-Emergent Central Sleep Apnea
Zinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.ChaptersTreatment-emergent central sleep apneaContinuous positive airway pressureCentral sleep apneaObstructive sleep apneaSleep apneaPositive airway pressureUpper airway collapsibilityUpper airway patencyMulti-modality therapyVentilatory control systemAirway collapsibilityAirway pressureOpioid useOSA patientsAirway patencyHeart failureAtrial fibrillationCarbonic anhydrase inhibitorsCentral sleepPoor adherenceOptimal treatmentSedative hypnoticsClinical careApneaMultifactorial nature
2016
Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches
Zinchuk AV, Gentry MJ, Concato J, Yaggi HK. Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches. Sleep Medicine Reviews 2016, 35: 113-123. PMID: 27815038, PMCID: PMC5389934, DOI: 10.1016/j.smrv.2016.10.002.BooksConceptsObstructive sleep apneaOSA phenotypesSleep apneaPathophysiologic risk factorsApnea-hypopnea indexCategory of patientsHypopnea indexClinical featuresPatient selectionRisk factorsClinical trialsClinical phenotypingDisease featuresSignificant prognosticPersonalized treatmentHeterogeneous disorderClinical validationTherapeutic categoriesTreatment implicationsUnderstanding of mechanismsMeaningful outcomesApneaPatientsPhenotypeLack association