2012
Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic Pain
Tan AM, Samad OA, Fischer TZ, Zhao P, Persson AK, Waxman SG. Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic Pain. Journal Of Neuroscience 2012, 32: 6795-6807. PMID: 22593049, PMCID: PMC6622192, DOI: 10.1523/jneurosci.1017-12.2012.Peer-Reviewed Original ResearchConceptsDiabetic neuropathic painNeuropathic painDendritic spinesSpine plasticitySpine morphologyMajor public health problemDiabetes-induced changesDevelopment of painDendritic spine remodelingDendritic spine plasticitySpontaneous firing activityPublic health problemAvailable clinical treatmentsEvidence of painDendritic spine morphologyDendritic spine shapeNeuronal hyperresponsivenessRange neuronsWDR neuronsNeuron hyperexcitabilitySTZ injectionDorsal hornMechanical painChronic painDiabetic rats
2009
Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing
Tan AM, Choi JS, Waxman SG, Hains BC. Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing. Journal Of Neurophysiology 2009, 102: 2396-2409. PMID: 19692517, DOI: 10.1152/jn.00095.2009.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injurySynaptic transmissionDorsal horn nociceptive neuronsFrequency-following abilityDendritic spine remodelingGeneration of painAction potential activationDendritic spine morphologyDendritic spine shapeAbnormal painCentral sensitizationNociceptive neuronsSpine remodelingPostsynaptic neuronsDendritic spinesSpine morphologyInput-output functionPainSoma resultsInjurySpine shapeNeuronal statesNeuronsPotential activation