2023
Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections
Wyart C, Jim K, Prendergast A. Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections. Neuroscience 2023, 525: 47-50. PMID: 37419406, DOI: 10.1016/j.neuroscience.2023.07.008.Peer-Reviewed Original ResearchConceptsSensory cellsNervous systemInternal physiologyPresence of pathogensExternal cuesRelease of compoundsPathogenic bacteriaCentral nervous systemHomeostatic regulationInternal cuesHost defenseNeuronal activationCellsClassical functionsHost responseReceptor propertiesSensory systemsCuesInfectionBacteriaRegulationPhysiologyField of neurosciencePathogensInvasionCSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
Prendergast A, Jim K, Marnas H, Desban L, Quan F, Djenoune L, Laghi V, Hocquemiller A, Lunsford E, Roussel J, Keiser L, Lejeune F, Dhanasekar M, Bardet P, Levraud J, van de Beek D, Vandenbroucke-Grauls C, Wyart C. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 2023, 33: 940-956.e10. PMID: 36791723, DOI: 10.1016/j.cub.2023.01.039.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidSensory neuronsNervous systemStreptococcus pneumoniaeCentral nervous system infectionBlockade of neurotransmissionCentral sensory neuronsNervous system infectionHost survivalPeripheral nervous systemCell-specific ablationEpileptic-like seizuresCSF-contacting neuronsSupernatants of cellsPneumococcal meningitisSystem infectionBitter taste receptorsCSF infectionPneumoniae infectionNeurotropic virusesSpinal cordPathogenic bacteriaPostural controlMeningitis
2017
The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports 2017, 7: 719. PMID: 28389647, PMCID: PMC5428266, DOI: 10.1038/s41598-017-00350-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsBiomarkersCarrier ProteinsCell DifferentiationCerebrospinal FluidFluorescent Antibody TechniqueGanglia, SpinalHomozygoteMutationNeuronsSensory Receptor CellsSignal TransductionSpinal CordSpinal Nerve RootsTRPP Cation ChannelsZebrafishZebrafish ProteinsConceptsDual developmental originDevelopmental originsDistinct progenitor domainsApical extensionDistinct functional subtypesDifferent developmental originsCerebrospinal fluid-contacting neuronsTranscription factorsMechanical cuesZebrafish larvaeDistinct functionsProgenitor domainsCentral nervous systemCell typesDistinct cascadesFunctional populationsDifferent functional propertiesCSF-cNsNovel avenuesPKD2L1 channelFunctional subtypesSensory neuronsNeuronal targetsDistinct functional populationsSpecific markers