2023
Enhanced Identification of Hispanic Ethnicity Using Clinical Data
Ochoa-Allemant P, Tate J, Williams E, Gordon K, Marconi V, Bensley K, Rentsch C, Wang K, Taddei T, Justice A, Cohorts F. Enhanced Identification of Hispanic Ethnicity Using Clinical Data. Medical Care 2023, 61: 200-205. PMID: 36893404, PMCID: PMC10114212, DOI: 10.1097/mlr.0000000000001824.Peer-Reviewed Original ResearchConceptsBurden of diseaseHispanic patientsCountry of birthClinical dataHispanic ethnicityNon-Hispanic white patientsSex-adjusted prevalenceChronic liver diseaseHuman immunodeficiency virusDemographic characteristicsElectronic health record dataHealth careHealth record dataPrevalence of conditionsUS health care systemMedicare administrative dataHealth care systemWhite patientsLiver diseaseImmunodeficiency virusSelf-reported ethnicityHigh prevalenceGastric cancerHepatocellular carcinomaVeteran population
2020
DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population
Shu C, Justice AC, Zhang X, Marconi VC, Hancock DB, Johnson EO, Xu K. DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population. Epigenetics 2020, 16: 741-753. PMID: 33092459, PMCID: PMC8216205, DOI: 10.1080/15592294.2020.1824097.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyMortality risk groupsAging Cohort StudyHigher mortality riskMortality riskRisk groupsCohort studyHigh mortality risk groupLow-mortality risk groupsInflammation response pathwayHIV-positive participantsHuman immunodeficiency virusLow-risk groupImproved life expectancyVACS IndexHIV populationNatural killerImmunodeficiency virusPredictive biomarkersPLWHDNA methylation biomarkersVeteran populationSurvival analysisEpigenome-wide associationHIVDNA methylation mediates the effect of cocaine use on HIV severity
Shu C, Justice AC, Zhang X, Wang Z, Hancock DB, Johnson EO, Xu K. DNA methylation mediates the effect of cocaine use on HIV severity. Clinical Epigenetics 2020, 12: 140. PMID: 32928285, PMCID: PMC7491141, DOI: 10.1186/s13148-020-00934-1.Peer-Reviewed Original ResearchConceptsHIV-positive participantsHIV severityVACS IndexCocaine useCocaine effectsVeterans Aging Cohort Study Biomarker CohortVeterans Aging Cohort Study (VACS) IndexEpigenome-wide associationHuman immunodeficiency virus (HIV) progressionHigher VACS indexFrequent cocaine useCandidate CpG sitesPersistent cocaine useMendelian randomization analysisHIV outcomesBiomarker cohortHIV progressionVirus progressionVAC indexVeteran populationAntiviral responseCandidate mediatorsStudy indicesMR analysisSeverityInsights Provided by Depression Screening Regarding Pain, Anxiety, and Substance use in a Veteran Population
Stevens ER, Mazumdar M, Caniglia EC, Khan MR, Young KE, Edelman EJ, Gordon AJ, Fiellin DA, Maisto SA, Chichetto NE, Crystal S, Gaither JR, Justice AC, Braithwaite RS. Insights Provided by Depression Screening Regarding Pain, Anxiety, and Substance use in a Veteran Population. Journal Of Primary Care & Community Health 2020, 11: 2150132720949123. PMID: 32772883, PMCID: PMC7418233, DOI: 10.1177/2150132720949123.Peer-Reviewed Original ResearchConceptsPositive predictive valueSubstance useOdds ratioVeterans Aging Cohort Study (VACS) dataPHQ-9 scoresPrimary care settingCohort study dataTest performance characteristicsSymptoms of anxietyMedian ageDepression screeningLikelihood ratio valuesDepression screenPHQ-9Care settingsVeteran populationPredictive valueSignificant associationSymptomsDiagnostic assessmentAnxietyStudy dataAdditional informationAssociationPain
2018
Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality
Zhang X, Hu Y, Aouizerat BE, Peng G, Marconi VC, Corley MJ, Hulgan T, Bryant KJ, Zhao H, Krystal JH, Justice AC, Xu K. Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality. Clinical Epigenetics 2018, 10: 155. PMID: 30545403, PMCID: PMC6293604, DOI: 10.1186/s13148-018-0591-z.Peer-Reviewed Original ResearchConceptsWhite blood cellsSmoking-associated DNA methylationHIV prognosisInfection-related clinical outcomesBlood cellsSmoking-associated CpGsHIV-positive individualsImmune-related outcomesEpigenome-wide significant CpGsClinical outcomesTobacco smokingVeteran populationSurvival rateDNA methylation indexMortalityFrailtyHIVMethylation indexPrognosisMethylation signaturesDNA methylationOutcomesCell cycleCpGSignificant CpGs
2015
THE ASSOCIATION BETWEEN HIV STATUS AND HOMELESSNESS AMONG VETERANS IN CARE
Ghose T, Gordon A, Metraux S, Mattocks K, Goulet J, Rodriguez‐Barradas M, Day N, Blackstock O, Justice A. THE ASSOCIATION BETWEEN HIV STATUS AND HOMELESSNESS AMONG VETERANS IN CARE. Journal Of Community Psychology 2015, 43: 189-198. DOI: 10.1002/jcop.21673.Peer-Reviewed Original ResearchVeterans Affairs Health Care SystemVeterans Aging Cohort StudyHIV-negative veteransSubstance useAging Cohort StudyAfrican American substance usersGeneral veteran populationHIV-positive statusHazardous alcohol useHealth care systemCohort studyHIV infectionHIV-positiveHIV statusHigh riskVeteran populationWomen veteransHIVAlcohol useCare systemSubstance usersHomelessness riskLast monthVeteransHomelessness prevalence
2006
Health‐Related Quality of Life in Veterans and Nonveterans with HIV/AIDS
Mrus JM, Leonard AC, Yi MS, Sherman SN, Fultz SL, Justice AC, Tsevat J. Health‐Related Quality of Life in Veterans and Nonveterans with HIV/AIDS. Journal Of General Internal Medicine 2006, 21: s39-s47. PMID: 17083499, PMCID: PMC1924783, DOI: 10.1111/j.1525-1497.2006.00644.x.Peer-Reviewed Original ResearchConceptsHIV/AIDSSymptom botherDepressive symptomsCorrelates of HRQOLPoorer overall functionDeterminants of HRQoLNon-VA settingsHealth-related qualityInjection drug useRating Scale scoresUnstable housing situationsVeterans Administration settingsQuality of lifeVeteran statusHealth valueOverall functionPoor HRQOLHRQOL outcomesMultivariable analysisHRQOL measuresMultivariable associationsMultivariable modelHRQoLVeteran populationHealth ratings
2001
Justification for a new cohort study of people aging with and without HIV infection
Justice AC, Landefeld CS, Asch SM, Gifford AL, Whalen CC, Covinsky KE. Justification for a new cohort study of people aging with and without HIV infection. Journal Of Clinical Epidemiology 2001, 54: s3-s8. PMID: 11750202, PMCID: PMC6563331, DOI: 10.1016/s0895-4356(01)00440-1.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyCohort studyChronic diseasesAging Cohort StudyLongitudinal cohort studyNew cohort studiesHIV/AIDSSubstance use/abuseUse/abuseNegative patientsHIV infectionOrgan injuryComorbid conditionsIatrogenic injuryDrug toxicityVeteran populationMethodologic issuesHIVDiseaseInjuryPopulationPatientsEtiologyInfectionStudy