2019
Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB)
Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.Peer-Reviewed Original ResearchConceptsTranslational activationBinding proteinSpecific protein complexesTranslation of mRNAsOocyte maturationCis-acting sequencesEarly embryo developmentProtein complexesXenopus modelEarly embryosKey regulatorGene expressionMolecular mechanismsEmbryo developmentTargeted disruptionMechanistic detailsProteinEarly developmentMRNAMice resultsKey mechanismOocytesActivationMaturationTranscription
2012
Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?
Kallen AN, Ma J, Huang Y. Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs? Frontiers In Genetics 2012, 3: 240. PMID: 23162570, PMCID: PMC3499807, DOI: 10.3389/fgene.2012.00240.Peer-Reviewed Original ResearchRNA helicase ARibonucleoprotein complexesDEAD-box protein familyMiRNA-mediated repressionATP-dependent unwindingTranslation of genesStimulation of translationFamily of miRNAsSubset of miRNAsRNA helicasesProtein familyTarget mRNAsSame mRNAGene expressionPleiotropic rolesLin28Mode of actionRNA duplexesCell growthNeuronal cellsMiRNAsMRNAComplementary sequencesBrain synaptic functionSynaptic function