2017
What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
Kuijt WJ, Green CL, Verouden NJW, Haeck JDE, Tzivoni D, Koch KT, Stone GW, Lansky AJ, Broderick S, Tijssen JGP, de Winter RJ, Roe MT, Krucoff MW. What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Journal Of Electrocardiology 2017, 50: 952-959. PMID: 29153151, DOI: 10.1016/j.jelectrocard.2017.04.009.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionST-segment recoveryPrimary percutaneous coronary interventionPercutaneous coronary interventionElevation myocardial infarctionInfarct sizeCoronary interventionMyocardial infarctionHolter ECG monitoringMyocardial infarct sizeSingle photon emissionMultivariable adjustmentClinical outcomesRisk factorsClinical trialsNoninvasive biomarkersCore laboratoryMechanistic correlatesMortalityECG monitoringInfarctionRecovery parametersST parametersInterventionOutcomes
2005
Low hematocrit predicts contrast-induced nephropathy after percutaneous coronary interventions
Nikolsky E, Mehran R, Lasic Z, Mintz GS, Lansky AJ, Na Y, Pocock S, Negoita M, Moussa I, Stone GW, Moses JW, Leon MB, Dangas G. Low hematocrit predicts contrast-induced nephropathy after percutaneous coronary interventions. Kidney International 2005, 67: 706-713. PMID: 15673320, DOI: 10.1111/j.1523-1755.2005.67131.x.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyPercutaneous coronary interventionBaseline hematocritCoronary interventionLow hematocritLower baseline hematocritChronic kidney diseaseGlomerular filtration rateImportant risk factorBaseline eGFRHematocrit dropLower eGFRConsecutive patientsIndependent predictorsKidney diseaseFiltration rateLowest quintileRisk factorsNephropathyPatientsHematocrit changesMultivariate analysisSignificant associationHematocrit valuesHematocritContrast-Induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables
Dangas G, Iakovou I, Nikolsky E, Aymong ED, Mintz GS, Kipshidze NN, Lansky AJ, Moussa I, Stone GW, Moses JW, Leon MB, Mehran R. Contrast-Induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables. The American Journal Of Cardiology 2005, 95: 13-19. PMID: 15619387, DOI: 10.1016/j.amjcard.2004.08.056.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyChronic kidney diseasePercutaneous coronary interventionIntra-aortic balloon pump useCoronary interventionKidney diseasePump usePredictors of CINPresence of CKDBaseline chronic kidney diseaseLower baseline hematocritBaseline renal functionContrast medium volumeHospital complicationsPeriprocedural hypotensionHospital stayBaseline characteristicsRenal functionConsecutive patientsEjection fractionBaseline hematocritPulmonary edemaHemodynamic variablesHemodynamic parametersPatients
2004
A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation
MEHRAN R, AYMONG E, NIKOLSKY E, LASIC Z, IAKOVOU I, FAHY M, MINTZ G, LANSKY A, MOSES J, STONE G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation. Journal Of The American College Of Cardiology 2004, 44: 1393-1399. DOI: 10.1016/s0735-1097(04)01445-7.Peer-Reviewed Original ResearchA simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention Development and initial validation
Mehran R, Aymong E, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz G, Lansky A, Moses J, Stone G, Leon M, Dangas G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention Development and initial validation. Journal Of The American College Of Cardiology 2004, 44: 1393-1399. PMID: 15464318, DOI: 10.1016/j.jacc.2004.06.068.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyPercutaneous coronary interventionSimple risk scoreRisk scoreRate of CINRisk of CINCandidate univariate predictorsMultivariate logistic regressionTotal risk scoreGood discriminative powerWeighted integerCoronary interventionIndependent predictorsUnivariate predictorsRisk factorsOdds ratioProcedural characteristicsCumulative riskPatientsLogistic regressionIntervention developmentOverall occurrenceInvestigational purposesNephropathyScoresMyocardial First-Pass Perfusion Magnetic Resonance Imaging
Wolff SD, Schwitter J, Coulden R, Friedrich MG, Bluemke DA, Biederman RW, Martin ET, Lansky AJ, Kashanian F, Foo TK, Licato PE, Comeau CR. Myocardial First-Pass Perfusion Magnetic Resonance Imaging. Circulation 2004, 110: 732-737. PMID: 15289374, DOI: 10.1161/01.cir.0000138106.84335.62.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAgedArea Under CurveCardiac CatheterizationContrast MediaCoronary AngiographyCoronary CirculationCoronary DiseaseDose-Response Relationship, DrugFalse Positive ReactionsFemaleGadolinium DTPAHumansHyperemiaMagnetic Resonance ImagingMaleMiddle AgedMyocardiumProspective StudiesROC CurveSensitivity and SpecificitySingle-Blind MethodConceptsObstructive coronary artery diseaseCoronary artery diseaseArtery diseaseFirst-pass perfusion magnetic resonance imagingReceiver-operating curve analysisHigher contrast dosesDose-ranging studyCoronary artery catheterizationLow-dose groupPerfusion magnetic resonance imagingQuantitative coronary angiographyFirst-pass perfusion imagingLeft ventricular myocardiumReceiver-operating curveMagnetic resonance imagingFirst-pass perfusion MRIGadopentetate dimeglumine injectionCoronary angiographyArtery catheterizationEfficacious doseClinical evaluationContrast doseMyocardial hyperemiaPerfusion defectsGadopentate dimeglumine
2003
Impact of Renal Insufficiency in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction
Sadeghi HM, Stone GW, Grines CL, Mehran R, Dixon SR, Lansky AJ, Fahy M, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Stuckey TD, Turco M, Carroll JD. Impact of Renal Insufficiency in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction. Circulation 2003, 108: 2769-2775. PMID: 14638545, DOI: 10.1161/01.cir.0000103623.63687.21.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAcute DiseaseAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalContrast MediaCoronary RestenosisCreatinineFemaleHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPredictive Value of TestsPrognosisProspective StudiesRenal InsufficiencyRisk AssessmentStentsSurvival RateTreatment OutcomeConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionBaseline renal insufficiencyRenal insufficiencyBaseline CrClMyocardial infarctionPrimary PCIPeripheral vascular diseasePowerful independent predictorPercutaneous coronary interventionRisk of mortalityTransfusion requirementsHemorrhagic complicationsPrimary angioplastySevere restenosisArtery reocclusionCoronary interventionCreatinine clearanceSymptom onsetHeart failureIndependent predictorsAMI patientsCerebrovascular diseasePoor prognosisPrognostic importanceImpact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention.
Iakovou I, Dangas G, Mehran R, Lansky AJ, Ashby DT, Fahy M, Mintz GS, Kent KM, Pichard AD, Satler LF, Stone GW, Leon MB. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. Journal Of Invasive Cardiology 2003, 15: 18-22. PMID: 12499523.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyChronic renal failureOne-year mortalityIndependent predictorsPercutaneous interventionDiabetes mellitusClinical outcomesFemale genderMultivariate analysisOne-year clinical eventsNYHA IV classSevere heart failurePercutaneous coronary interventionImpact of genderCoronary interventionRenal failureHeart failureMale patientsCIN developmentClinical eventsPatientsMortalityMellitusNephropathySignificant gender differences
2000
Randomized Trial of Contrast Media Utilization in High-Risk PTCA
Davidson C, Laskey W, Hermiller J, Harrison J, Matthai W, Vlietstra R, Brinker J, Kereiakes D, Muhlestein J, Lansky A, Popma J, Buchbinder M, Hirshfeld J. Randomized Trial of Contrast Media Utilization in High-Risk PTCA. Circulation 2000, 101: 2172-2177. PMID: 10801758, DOI: 10.1161/01.cir.101.18.2172.Peer-Reviewed Original ResearchConceptsMajor adverse clinical eventsHospital major adverse clinical eventsPrimary end pointClinical eventsNonionic dimer iodixanolDimer iodixanolEnd pointLow-osmolar contrast agentsHigh-risk PTCAHospital clinical eventsThrombus-related eventsTotal clinical eventsDouble-blind trialAcute coronary syndromeHigh-risk patientsProspective multicenter trialAdverse clinical eventsCoronary artery interventionPTCA outcomeAngiographic successCoronary syndromeNovo lesionsArtery interventionMulticenter trialRandomized trials