2020
Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L, Stone GW. Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. JACC Cardiovascular Imaging 2020, 13: 2206-2219. PMID: 32417338, DOI: 10.1016/j.jcmg.2020.02.028.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsHumansPlaque, AtheroscleroticPredictive Value of TestsUltrasonography, InterventionalConceptsHigh endothelial shear stressEndothelial shear stressLipid-rich plaquesPlaque burdenCardiovascular eventsPlaque characteristicsMajor adverse cardiovascular eventsSmaller minimum lumen areaLow endothelial shear stressHigh-risk anatomyAdverse cardiovascular eventsUseful prognostic informationQuantitative coronary angiographyMinimum lumen areaPrediction of lesionsLipid-rich lesionsESS valuesCoronary angiographyIndependent predictorsMultivariable analysisHemodynamic variablesPrognostic valueVH-IVUSHemodynamic indicesPrognostic informationPredictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study
Safi H, Bourantas CV, Ramasamy A, Zanchin T, Bär S, Tufaro V, Jin C, Torii R, Karagiannis A, Reiber JHC, Mathur A, Onuma Y, Windecker S, Lansky A, Maehara A, Serruys PW, Stone P, Baumbach A, Stone GW, Räber L. Predictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study. The International Journal Of Cardiovascular Imaging 2020, 36: 993-1002. PMID: 32152810, DOI: 10.1007/s10554-020-01805-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesRupture, SpontaneousSeverity of Illness IndexTime FactorsUltrasonography, InterventionalConceptsVirtual histology intravascular ultrasoundQuantitative flow ratioMinimum lumen diameterMinimum lumen areaCoronary angiographyPlaque burdenIBIS-4 studyPrognostic informationVulnerable plaquesSmaller minimum lumen areaMajor adverse cardiac eventsVulnerable phenotypeAdverse cardiac eventsGreater plaque burdenPredictors of MACENon-culprit lesionsAdditional prognostic informationSmaller minimum lumen diameterUseful prognostic informationQuantitative coronary angiographyAdditive valueCardiac eventsPlaque characteristicsLesion severityAngiographic data
2019
Feasibility of Shockwave Coronary Intravascular Lithotripsy for the Treatment of Calcified Coronary Stenoses
Brinton TJ, Ali ZA, Hill JM, Meredith IT, Maehara A, Illindala U, Lansky A, Götberg M, Van Mieghem NM, Whitbourn R, Fajadet J, Di Mario C. Feasibility of Shockwave Coronary Intravascular Lithotripsy for the Treatment of Calcified Coronary Stenoses. Circulation 2019, 139: 834-836. PMID: 30715944, DOI: 10.1161/circulationaha.118.036531.Peer-Reviewed Original Research
2017
Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events The PROSPECT Study
Stone PH, Maehara A, Coskun AU, Maynard CC, Zaromytidou M, Siasos G, Andreou I, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Lansky AJ, Mintz GS, Serruys PW, Feldman CL, Stone GW. Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events The PROSPECT Study. JACC Cardiovascular Imaging 2017, 11: 462-471. PMID: 28917684, DOI: 10.1016/j.jcmg.2017.01.031.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionEndothelium, VascularEuropeHumansPercutaneous Coronary InterventionPilot ProjectsPlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsStress, MechanicalTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsMajor adverse cardiac eventsLow endothelial shear stressMinimum lumen areaAcute coronary syndromeEndothelial shear stressAdverse cardiac eventsPlaque burdenCoronary lesionsNC-MACECardiac eventsAnatomic riskNC lesionsFuture major adverse cardiac eventsHigh-risk acute coronary syndromesBaseline endothelial shear stressHuman-like animal modelsPrevious natural history studiesPropensity-adjusted Cox regressionSmaller minimum lumen areaPROSPECT studyLocal endothelial shear stressHigh anatomic riskHigh endothelial shear stressNonculprit coronary lesionsHigh-risk patients
2016
Impact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study
Kedhi E, Kennedy MW, Maehara A, Lansky AJ, McAndrew TC, Marso SP, De Bruyne B, Serruys PW, Stone GW. Impact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study. JACC Cardiovascular Imaging 2016, 10: 451-458. PMID: 27372016, DOI: 10.1016/j.jcmg.2015.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDiabetes MellitusDisease ProgressionFemaleFibrosisHumansMaleMiddle AgedPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsPropensity ScoreRisk FactorsRupture, SpontaneousTime FactorsTreatment OutcomeUltrasonography, InterventionalConceptsMajor adverse cardiac eventsAcute coronary syndromeThin-cap fibroatheromaNonculprit lesionsDiabetes mellitusACS patientsDM patientsSubsequent major adverse cardiac eventsPresence of DMPROSPECT studyAdverse cardiac eventsPropensity-matched groupsRadiofrequency intravascular ultrasoundHigh rateCoronary syndromeCardiac eventsPlaque compositionIntravascular ultrasoundPatientsPropensity scoreBalanced groupsIschemicMellitusFibroatheromaPrognosis
2015
Lumen Measurements From Quantitative Coronary Angiography and IVUS: A PROSPECT Substudy
Goto K, Mintz GS, Litherland C, Lansky AJ, Weisz G, McPherson JA, De Bruyne B, Serruys PW, Stone GW, Maehara A. Lumen Measurements From Quantitative Coronary Angiography and IVUS: A PROSPECT Substudy. JACC Cardiovascular Imaging 2015, 9: 1011-1013. PMID: 26363838, DOI: 10.1016/j.jcmg.2015.07.006.Peer-Reviewed Original ResearchThe Variation in Recovery
Spatz ES, Curry LA, Masoudi FA, Zhou S, Strait KM, Gross CP, Curtis JP, Lansky AJ, Soares Barreto-Filho JA, Lampropulos JF, Bueno H, Chaudhry SI, D'Onofrio G, Safdar B, Dreyer RP, Murugiah K, Spertus JA, Krumholz HM. The Variation in Recovery. Circulation 2015, 132: 1710-1718. PMID: 26350057, PMCID: PMC4858327, DOI: 10.1161/circulationaha.115.016502.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAlgorithmsAortic DissectionClassificationCoronary DiseaseDiagnostic Techniques, CardiovascularFemaleHumansMaleMedical RecordsMiddle AgedMyocardial InfarctionMyocardiumOxygen ConsumptionPhenotypePlaque, AtheroscleroticProspective StudiesReproducibility of ResultsRisk FactorsSex FactorsTreatment OutcomeYoung AdultConceptsAcute myocardial infarctionCoronary artery diseaseArtery diseaseClinical phenotypeNonobstructive coronary artery diseaseYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseYoung womenType 2 acute myocardial infarctionBiological disease mechanismsSubset of patientsThird universal definitionUnique clinical phenotypeCulprit lesionClinical characteristicsMyocardial infarctionTherapeutic efficacyUniversal definitionStudy participantsPatientsSupply-demand mismatchYoung adultsDisease mechanismsPatient studiesCurrent classification schemesMorphological changes and clinical impact of unstable plaques within untreated segments of acute myocardial infarction patients during a 3-year follow-up
Souza CF, Doi H, Mintz GS, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie BR, Kellett MA, Xu K, Mehran R, Stone GW, Maehara A. Morphological changes and clinical impact of unstable plaques within untreated segments of acute myocardial infarction patients during a 3-year follow-up. Coronary Artery Disease 2015, 26: 469-475. PMID: 25919902, DOI: 10.1097/mca.0000000000000251.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseCoronary VesselsFemaleHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlaque, AtheroscleroticPlatelet Aggregation InhibitorsPredictive Value of TestsProspective StudiesRisk FactorsRupture, SpontaneousStentsTime FactorsTreatment OutcomeUltrasonography, InterventionalWound HealingConceptsST-segment elevation myocardial infarctionPlaque ruptureIntravascular ultrasoundClinical eventsUnstable plaquesLumen compromiseUntreated segmentsAcute Myocardial Infarction trialLong-term clinical outcomesAcute myocardial infarction patientsBaseline intravascular ultrasoundOptimal systemic therapySerial IVUS analysisMyocardial Infarction trialElevation myocardial infarctionInfarct-related arteryMyocardial infarction patientsThree-year followAttenuated plaqueHarmonizing OutcomesNonculprit lesionsSTEMI patientsSystemic therapyClinical outcomesInfarction patients
2014
Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT Study)
Kelly CR, Weisz G, Maehara A, Mintz GS, Mehran R, Lansky AJ, Parise H, de Bruyne B, Serruys PW, Stone GW. Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT Study). The American Journal Of Cardiology 2014, 114: 376-383. PMID: 24931291, DOI: 10.1016/j.amjcard.2014.04.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCoronary AngiographyCoronary Artery DiseaseC-Reactive ProteinDisease ProgressionFemaleGlobal HealthHumansIncidenceInflammationMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSurvival RateTime FactorsConceptsMajor adverse cardiac eventsC-reactive protein levelsNonculprit lesionsElevated CRP levelsCRP levelsVulnerable coronary plaquesIntravascular ultrasoundCoronary plaquesPost-acute coronary syndrome patientsSubsequent major adverse cardiac eventsGray-scale intravascular ultrasoundCoronary Tree (PROSPECT) studyUntreated nonculprit lesionsAdverse cardiac eventsAdverse coronary eventsAcute coronary syndromeCoronary syndrome patientsPercutaneous coronary interventionRadiofrequency intravascular ultrasoundPredictors of eventsProtein levelsMinimal luminal areaHigh rateCoronary eventsCoronary syndrome
2013
Almanac 2013: acute coronary syndromes
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. Heart 2013, 99: 1488. PMID: 23945172, DOI: 10.1136/heartjnl-2013-304649.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeCoronary AngiographyElectrocardiographyGlobal HealthHumansIncidenceMyocardial RevascularizationPlaque, AtheroscleroticSurvival RateConceptsST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelorNon-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study
Dohi T, Mintz GS, McPherson JA, de Bruyne B, Farhat NZ, Lansky AJ, Mehran R, Weisz G, Xu K, Stone GW, Maehara A. Non-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study. JACC Cardiovascular Imaging 2013, 6: 908-916. PMID: 23850249, DOI: 10.1016/j.jcmg.2013.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedAngina, UnstableChi-Square DistributionCoronary VesselsFemaleFibrosisHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPercutaneous Coronary InterventionPhenotypePlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalVascular CalcificationConceptsMajor adverse cardiac eventsAcute coronary syndromeNonculprit lesionsClinical outcomesLong-term clinical outcomesVirtual histology intravascular ultrasoundPROSPECT studyCox proportional hazards modelAdverse cardiac eventsIntermediate-term prognosisSuccessful percutaneous interventionOverall plaque burdenLesion phenotypeFA lesionsProportional hazards modelSubstudy analysisCoronary syndromeCulprit lesionCardiac eventsPlaque burdenClinical eventsVH-IVUSPercutaneous interventionClinical impactHazards modelPlaque shift and distal embolism in patients with acute myocardial infarction
Wu X, Maehara A, He Y, Xu K, Oviedo C, Witzenbichler B, Lansky AJ, Dressler O, Parise H, Stone GW, Mintz GS. Plaque shift and distal embolism in patients with acute myocardial infarction. Catheterization And Cardiovascular Interventions 2013, 82: 203-209. PMID: 22936619, DOI: 10.1002/ccd.24644.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisCoronary VesselsCreatine Kinase, MB FormEmbolismFemaleHumansLinear ModelsMaleMiddle AgedMyocardial InfarctionNo-Reflow PhenomenonPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsProsthesis DesignRandomized Controlled Trials as TopicRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalConceptsThrombus groupCK-MBAngiographic thrombusPlaque shiftReference segmentsAxial plaque redistributionDistal plaque embolizationDistal reference segmentsHORIZONS-AMI trialNative coronary lesionsM volumeAcute myocardial infarctionVolumetric intravascular ultrasoundBare metal stentsOverall plaque volumePeriprocedural elevationPlaque redistributionDistal embolismCoronary lesionsPlaque embolizationMyocardial infarctionStent implantationPlaque volumeInfarction lesionsIntravascular ultrasound
2012
Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study.
Ruiz-García J, Lerman A, Weisz G, Maehara A, Mintz GS, Fahy M, Xu K, Lansky AJ, Cristea E, Farah TG, Teles R, Botker HE, Templin B, Zhang Z, de Bruyne B, Serruys PW, Stone GW. Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study. EuroIntervention 2012, 8: 929-38. PMID: 23253546, DOI: 10.4244/eijv8i8a142.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsAcute coronary syndromeNon-culprit lesionsUntreated non-culprit lesionsCoronary syndromePlaque burdenIncidence of MACEAge groupsObstructive coronary artery diseaseNecrotic coreGreater plaque burdenLarger plaque volumeAdverse cardiac eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundYears of ageSame age groupGender-specific differencesSex-related effectsCardiac eventsArtery diseaseAdverse outcomesAtherosclerosis developmentCoronary plaquesGender-related changesAn intravascular ultrasound appraisal of atherosclerotic plaque distribution in diseased coronary arteries
Golinvaux N, Maehara A, Mintz GS, Lansky AJ, McPherson J, Farhat N, Marso S, de Bruyne B, Serruys PW, Templin B, Cheong WF, Aaskar R, Fahy M, Mehran R, Leon M, Stone GW. An intravascular ultrasound appraisal of atherosclerotic plaque distribution in diseased coronary arteries. American Heart Journal 2012, 163: 624-631. PMID: 22520529, DOI: 10.1016/j.ahj.2011.07.031.Peer-Reviewed Original ResearchConceptsRight coronary arteryCoronary arteryPlaque burdenDistal segmentsDistal LADDistal right coronary arteryAtherosclerotic plaque distributionAnterior descending (LAD) arteryDistal coronary arteriesProximal coronary arteriesDiseased coronary arteriesExternal elastic membraneProximal cross sectionsArtery plaquesIntravascular ultrasound dataPlaque distributionProximal vesselsMid segmentsIntravascular ultrasoundMedian percentageArteryProximal segmentSignificant diseaseLADDiseasePlaque Composition and Clinical Outcomes in Acute Coronary Syndrome Patients With Metabolic Syndrome or Diabetes
Marso SP, Mercado N, Maehara A, Weisz G, Mintz GS, McPherson J, Schiele F, Dudek D, Fahy M, Xu K, Lansky A, Templin B, Zhang Z, de Bruyne B, Serruys PW, Stone GW. Plaque Composition and Clinical Outcomes in Acute Coronary Syndrome Patients With Metabolic Syndrome or Diabetes. JACC Cardiovascular Imaging 2012, 5: s42-s52. PMID: 22421230, DOI: 10.1016/j.jcmg.2012.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDiabetes MellitusEuropeFemaleHeart ArrestHumansKaplan-Meier EstimateMaleMetabolic SyndromeMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTomography, X-Ray ComputedTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsMajor adverse cardiac eventsGreater necrotic coreUntreated nonculprit lesionsAcute coronary syndromeMet SynNonculprit lesionsPercutaneous coronary interventionSYN patientsNecrotic coreMACE rateMetabolic syndromePlaque burdenFuture major adverse cardiac eventsSubsequent major adverse cardiac eventsAcute coronary syndrome patientsSuccessful percutaneous coronary interventionGreater plaque burdenAdverse cardiac eventsCoronary syndrome patientsHigh-risk groupQuantitative coronary angiographySmaller lumen areaACS patientsCoronary syndromeACS populationResidual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention
McPherson JA, Maehara A, Weisz G, Mintz GS, Cristea E, Mehran R, Foster M, Verheye S, Rabbani L, Xu K, Fahy M, Templin B, Zhang Z, Lansky AJ, de Bruyne B, Serruys PW, Stone GW. Residual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention. JACC Cardiovascular Imaging 2012, 5: s76-s85. PMID: 22421234, DOI: 10.1016/j.jcmg.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsMajor adverse cardiovascular eventsSuccessful percutaneous coronary interventionPercutaneous coronary interventionAcute coronary syndromePlaque burdenThin-cap fibroatheromaNonculprit lesionsIntravascular ultrasoundCardiovascular eventsCoronary syndromeCoronary interventionAtherosclerotic diseaseSignificant lesionsFuture major adverse cardiovascular eventsPrior percutaneous coronary interventionMean diameter stenosisMean plaque burdenPercent plaque volumeResidual plaque burdenUntreated nonculprit lesionsAdverse cardiovascular eventsFuture cardiovascular eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundAtherosclerotic burdenLongitudinal Distribution of Plaque Burden and Necrotic Core–Rich Plaques in Nonculprit Lesions of Patients Presenting With Acute Coronary Syndromes
Wykrzykowska JJ, Mintz GS, Garcia-Garcia HM, Maehara A, Fahy M, Xu K, Inguez A, Fajadet J, Lansky A, Templin B, Zhang Z, de Bruyne B, Weisz G, Serruys PW, Stone GW. Longitudinal Distribution of Plaque Burden and Necrotic Core–Rich Plaques in Nonculprit Lesions of Patients Presenting With Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s10-s18. PMID: 22421223, DOI: 10.1016/j.jcmg.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary Artery DiseaseCoronary StenosisCoronary VesselsEuropeFemaleHumansLipidsMaleMiddle AgedMyocardial InfarctionNecrosisPhenotypePlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsLeft main coronary arteryVirtual histology intravascular ultrasoundAcute coronary syndromePlaque burdenDistal coronary treeNonculprit lesionsCoronary syndromeVH-TCFACoronary arteryCoronary treeNecrotic core contentAcute coronary eventsEpicardial coronary arteriesMain coronary arteryAtherosclerotic plaque burdenAcute myocardial infarctionLong segmentCoronary eventsAnterior descendingMyocardial infarctionVulnerable plaquesProportion of NCsArteryLesionsPROSPECT studyCoronary Plaque Composition, Morphology, and Outcomes in Patients With and Without Chronic Kidney Disease Presenting With Acute Coronary Syndromes
Baber U, Stone GW, Weisz G, Moreno P, Dangas G, Maehara A, Mintz GS, Cristea E, Fahy M, Xu K, Lansky AJ, Wennerblom B, Mathey DG, Templin B, Zhang Z, Serruys PW, Mehran R. Coronary Plaque Composition, Morphology, and Outcomes in Patients With and Without Chronic Kidney Disease Presenting With Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s53-s61. PMID: 22421231, DOI: 10.1016/j.jcmg.2011.12.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChronic DiseaseCoronary AngiographyCoronary Artery DiseaseEuropeFemaleFibrosisHeart ArrestHumansKaplan-Meier EstimateKidney DiseasesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsAcute coronary syndromeChronic kidney diseasePercutaneous coronary interventionCoronary plaque compositionNonculprit lesionsPlaque compositionCoronary syndromeAdverse eventsCoronary interventionCardiac deathKidney diseaseMyocardial infarctionNecrotic coreFibrous tissueGreater necrotic coreUntreated nonculprit lesionsRadiofrequency intravascular ultrasoundCoronary atherosclerotic plaque compositionMinimal luminal areaPercentage of plaqueLesion-level analysisIntravascular ultrasound parametersAtherosclerotic plaque compositionCKD patientsCulprit lesionCharacteristics and Clinical Significance of Angiographically Mild Lesions in Acute Coronary Syndromes
Brener SJ, Mintz GS, Cristea E, Weisz G, Maehara A, McPherson JA, Marso SP, Farhat N, Botker HE, Dressler O, Xu K, Templin B, Zhang Z, Lansky AJ, de Bruyne B, Serruys PW, Stone GW. Characteristics and Clinical Significance of Angiographically Mild Lesions in Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s86-s94. PMID: 22421235, DOI: 10.1016/j.jcmg.2011.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleFibrosisHumansKaplan-Meier EstimateMaleMiddle AgedNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecurrenceRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsAcute coronary syndromePercutaneous coronary interventionMajor adverse cardiac eventsAdverse cardiac eventsCoronary syndromeNC lesionsCoronary interventionCardiac eventsDiameter stenosisSuccessful percutaneous coronary interventionMedian diameter stenosisRecurrent ischemic eventsThin-cap fibroatheromaNonculprit lesionsIschemic eventsUntreated lesionsClinical eventsClinical significanceMild lesionsPatientsLesionsNormal segmentsOne-halfSyndromeRecurrent eventsGender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes
Lansky AJ, Ng VG, Maehara A, Weisz G, Lerman A, Mintz GS, De Bruyne B, Farhat N, Niess G, Jankovic I, Lazar D, Xu K, Fahy M, Serruys PW, Stone GW. Gender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s62-s72. PMID: 22421232, DOI: 10.1016/j.jcmg.2012.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleFibrosisHeart ArrestHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsThin-cap fibroatheromaSimilar plaque burdenAcute coronary syndromePlaque burdenNonculprit lesionsCoronary syndromePlaque rupturePlaque compositionExtensive coronary artery diseaseMajor adverse cardiovascular eventsAcute coronary syndrome eventPROSPECT studyComposition of atherosclerosisNecrotic core volumeThick-cap fibroatheromaUntreated nonculprit lesionsAdverse cardiovascular eventsComorbid risk factorsCoronary artery diseaseMinimal lumen areaSex-based subgroup analysisPathological intimal thickeningCardiovascular eventsMultivariable adjustmentComorbid diseases