2024
Right Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella
Rommel K, Bonnet G, Bellumkonda L, Lansky A, Zhao D, Thompson J, Zhang Y, Redfors B, Lurz P, Granada J, Bharadwaj A, Basir M, O'Neill W, Burkhoff D. Right Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella. Journal Of Cardiac Failure 2024, 30: 1244-1254. PMID: 39389734, DOI: 10.1016/j.cardfail.2024.08.001.Peer-Reviewed Original ResearchConceptsRight ventricular dysfunctionHigh-risk percutaneous coronary interventionVentricular dysfunctionAssociated with right ventricular dysfunctionTricuspid annular plane systolic excursionConcomitant right ventricular dysfunctionLower left ventricular ejection fractionUnfavorable long-term prognosisAnnular plane systolic excursionClinical outcomes of patientsAbsence of right ventricular dysfunctionImpella supportPredictor of 1-year mortalityMultivariate Cox regression analysisIncidence of hypotensive episodesEchocardiography core laboratorySevere RV dilatationBlood urea nitrogen levelsRV function assessmentVentricular ejection fractionOutcomes of patientsRates of in-hospital mortalityHigher blood urea nitrogen levelsLong-term prognosisProportion of patients
2020
Frequency of Management of Cardiogenic Shock With Mechanical Circulatory Support Devices According to Race
Kim Y, Park J, Essa M, Lansky AJ, Sugeng L. Frequency of Management of Cardiogenic Shock With Mechanical Circulatory Support Devices According to Race. The American Journal Of Cardiology 2020, 125: 1782-1787. PMID: 32471549, DOI: 10.1016/j.amjcard.2020.03.025.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMechanical circulatory supportCardiogenic shockNational Inpatient SampleHospital mortalityBlack patientsInpatient SampleMCS devicesPopulation-based retrospective cohort studyMCS utilizationMechanical circulatory support devicesOnly black patientsRetrospective cohort studyClinical Modification codesMultivariate logistic regressionCirculatory support devicesAcute clinical scenariosHospital outcomesCohort studyPrimary outcomeClinical outcomesHospital eventsCirculatory supportNinth RevisionMyocardial infarction
2019
Predictors of In-Hospital Mortality after Transcatheter Aortic Valve Implantation
Krittanawong C, Kumar A, Wang Z, Johnson KW, Rastogi U, Narasimhan B, Kaplin S, Virk HUH, Baber U, Tang W, Lansky AJ, Stone GW. Predictors of In-Hospital Mortality after Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2019, 125: 251-257. PMID: 31759517, DOI: 10.1016/j.amjcard.2019.10.014.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationBaseline heart failureAortic valve implantationHeart failureAdditional independent predictorsHospital mortalityEjection fractionIndependent predictorsValve implantationPresence of HFReduced ejection fractionSevere aortic stenosisIn-Hospital MortalityPredictors of mortalityPotential baseline confoundersAortic valve stenosisICD-9 codesAbsence of depressionTAVI patientsHF patientsAortic stenosisValve stenosisLiver diseaseMultivariable analysisPatient selection
2012
Clinical Outcomes Following Stent Thrombosis Occurring In-Hospital Versus Out-of-Hospital Results From the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) Trial
Dangas GD, Claessen BE, Mehran R, Brener S, Brodie BR, Dudek D, Witzenbichler B, Peruga JZ, Guagliumi G, Moses JW, Lansky AJ, Xu K, Stone GW. Clinical Outcomes Following Stent Thrombosis Occurring In-Hospital Versus Out-of-Hospital Results From the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2012, 59: 1752-1759. PMID: 22575312, DOI: 10.1016/j.jacc.2011.12.042.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionHospital stent thrombosisPrimary percutaneous coronary interventionGlycoprotein IIb/IIIa inhibitorsHORIZONS-AMI trialStent thrombosisMajor bleedingClinical outcomesUnfractionated heparinMyocardial infarctionST eventsPrimary PCIIIb/IIIa inhibitorsProbable stent thrombosisAcademic Research ConsortiumElevation myocardial infarctionPercutaneous coronary interventionSTEMI patientsCoronary interventionHospital phaseBetter prognosisMultivariable analysisReperfusion resultsSubgroup analysisMost deaths
2011
Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial
Palmerini T, Genereux P, Caixeta A, Cristea E, Lansky A, Mehran R, Dangas G, Lazar D, Sanchez R, Fahy M, Xu K, Stone GW. Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial. Journal Of The American College Of Cardiology 2011, 57: 2389-2397. PMID: 21658558, DOI: 10.1016/j.jacc.2011.02.032.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassElectrocardiographyEmergency TreatmentFemaleHeparin, Low-Molecular-WeightHirudinsHospital MortalityHumansItalyKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPeptide FragmentsPrognosisProportional Hazards ModelsProspective StudiesRecombinant ProteinsRisk AssessmentROC CurveSeverity of Illness IndexStatistics, NonparametricSurvival AnalysisTreatment OutcomeTriageConceptsSegment elevation acute coronary syndromesElevation acute coronary syndromePercutaneous coronary interventionAcute coronary syndromeSYNTAX scoreCoronary syndromeCardiac deathACUITY trialIndependent predictorsPredictive valueTarget vessel revascularization rateStable ischemic heart diseaseTriple-vessel coronary diseaseVessel revascularization rateCardiac mortality rateMyocardial infarction ratePre-specified subgroupsRisk-stratify patientsIschemic heart diseaseAngiographic substudySS tertilesInfarction rateRevascularization ratesCoronary interventionCoronary disease
2010
A Risk Score to Predict Bleeding in Patients With Acute Coronary Syndromes
Mehran R, Pocock SJ, Nikolsky E, Clayton T, Dangas GD, Kirtane AJ, Parise H, Fahy M, Manoukian SV, Feit F, Ohman ME, Witzenbichler B, Guagliumi G, Lansky AJ, Stone GW. A Risk Score to Predict Bleeding in Patients With Acute Coronary Syndromes. Journal Of The American College Of Cardiology 2010, 55: 2556-2566. PMID: 20513595, DOI: 10.1016/j.jacc.2009.09.076.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAngioplasty, Balloon, CoronaryCause of DeathConfidence IntervalsCoronary AngiographyCoronary Artery BypassElectrocardiographyFemaleFibrinolytic AgentsHemorrhageHeparinHospital MortalityHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexPredictive Value of TestsProbabilityProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSurvival AnalysisTreatment OutcomeConceptsAcute coronary syndromeInteger risk scoreMajor bleedingRisk scoreCoronary syndromeNon-coronary artery bypass graft surgerySubsequent mortalityCox proportional hazards regression modelArtery bypass graft surgeryProportional hazards regression modelsMultivariable logistic regression modelHORIZONS-AMI trialPractical risk scoreBypass graft surgerySimple risk scoreIndependent baseline predictorsTreatment-related variablesHazards regression modelsAppropriate treatment strategyLogistic regression modelsGraft surgeryHemorrhagic complicationsIdentifies patientsBlood transfusionLarge hematomaImpact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial)
Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Möckel M, Ochala A, Mehran R, Stone GW. Impact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial). The American Journal Of Cardiology 2010, 105: 1385-1394. PMID: 20451683, DOI: 10.1016/j.amjcard.2010.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaAngioplasty, Balloon, CoronaryCombined Modality TherapyDrug Therapy, CombinationElectrocardiographyFemaleFibrinolytic AgentsFollow-Up StudiesHeparinHirudinsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNeoadjuvant TherapyPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProbabilityProportional Hazards ModelsRecombinant ProteinsRisk AssessmentSex FactorsSurvival AnalysisThrombolytic TherapyTreatment OutcomeConceptsST-elevation myocardial infarctionElevation myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsBaseline anemiaPercutaneous coronary interventionAdjunctive antithrombotic therapyMajor bleedingMyocardial infarctionAntithrombotic therapyCoronary interventionUnfractionated heparinST-segment elevation myocardial infarctionMultivariate analysisAcute Myocardial Infarction trialImpact of anemiaMyocardial Infarction trialOutcomes of patientsHarmonizing OutcomesCardiac mortalityCause mortalityLate mortalityPrimary PCIClinical outcomes
2007
An evaluation of fluoroscopy time and correlation with outcomes after percutaneous coronary intervention.
Nikolsky E, Pucelikova T, Mehran R, Balter S, Kaufman L, Fahy M, Lansky AJ, Leon MB, Moses JW, Stone GW, Dangas G. An evaluation of fluoroscopy time and correlation with outcomes after percutaneous coronary intervention. Journal Of Invasive Cardiology 2007, 19: 208-13. PMID: 17476034.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCohort StudiesCoronary AngiographyCoronary Artery BypassCoronary DiseaseElectrocardiographyFemaleFluoroscopyFollow-Up StudiesHospital MortalityHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProbabilityRetrospective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival RateTime FactorsTreatment OutcomeConceptsCoronary artery bypass surgeryPercutaneous coronary interventionEmergent coronary artery bypass surgeryPrior coronary artery bypass surgeryProlonged fluoroscopy timeContrast-induced nephropathyPeripheral arterial diseaseFluoroscopy timeBaseline TIMICoronary interventionArterial diseaseComplexity of PCIType B2/C lesionsB2/C lesionsSevere lesion calcificationChronic renal insufficiencyArtery bypass surgeryShort-term prognosisMean fluoroscopy timeHospital deathHospital outcomesPeriprocedural complicationsRenal insufficiencyBypass surgeryLesion calcification
2004
Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention Analysis from the controlled abciximab and device investigation to lower late angioplasty complications (cadillac) trial
Nikolsky E, Aymong ED, Halkin A, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Cohen DA, Negoita M, Lansky AJ, Stone GW. Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention Analysis from the controlled abciximab and device investigation to lower late angioplasty complications (cadillac) trial. Journal Of The American College Of Cardiology 2004, 44: 547-553. PMID: 15358018, DOI: 10.1016/j.jacc.2004.03.080.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAnemiaAngioplasty, Balloon, CoronaryAntibodies, MonoclonalBlood Component TransfusionFemaleHematocritHemorrhageHospital MortalityHumansImmunoglobulin Fab FragmentsIncidenceMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsPredictive Value of TestsPrognosisRandomized Controlled Trials as TopicStentsStrokeSurvival AnalysisTreatment OutcomeConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCILate Angioplasty Complications (CADILLAC) trialImpact of anemiaComplications TrialMyocardial infarctionWorld Health Organization criteriaPrimary PCI outcomesBlood product transfusionOne-year mortalityBaseline laboratory valuesPercutaneous coronary interventionPresence of anemiaBaseline anemiaControlled AbciximabHospital mortalityProduct transfusionHemorrhagic complicationsIndex hospitalizationCoronary interventionIndependent predictorsPCI outcomesPrognostic importanceAdverse outcomesPrognostic significance of cerebrovascular and peripheral arterial disease in patients having percutaneous coronary interventions
Nikolsky E, Mehran R, Dangas GD, Lasic Z, Mintz GS, Negoita M, Lansky AJ, Stone GW, Moussa I, Iyer S, Na Y, Moses JW, Leon MB. Prognostic significance of cerebrovascular and peripheral arterial disease in patients having percutaneous coronary interventions. The American Journal Of Cardiology 2004, 93: 1536-1539. PMID: 15194030, DOI: 10.1016/j.amjcard.2004.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryBody Mass IndexCase-Control StudiesCerebrovascular DisordersCoronary Artery DiseaseDiabetes ComplicationsFemaleHospital MortalityHumansKidney Failure, ChronicLength of StayLogistic ModelsMaleMiddle AgedMultivariate AnalysisPeripheral Vascular DiseasesPrognosisSaphenous VeinSex FactorsImpact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz GS, Dangas GD, Lansky AJ, Aymong ED, Negoita M, Fahy M, Moussa I, Roubin GS, Moses JW, Stone GW, Leon MB. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. PMID: 14748627, DOI: 10.1177/152660280401100108.Peer-Reviewed Original ResearchConceptsSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypass
2002
Minimally invasive direct coronary artery bypass (MIDCAB) versus coronary artery stenting for elective revascularization of the left anterior descending artery
Iakovou I, Dangas G, Mehran R, Lansky AJ, Stamou SC, Pfister AJ, Dullum MK, Leon MB, Corso PJ. Minimally invasive direct coronary artery bypass (MIDCAB) versus coronary artery stenting for elective revascularization of the left anterior descending artery. The American Journal Of Cardiology 2002, 90: 885-887. PMID: 12372581, DOI: 10.1016/s0002-9149(02)02715-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngioplasty, Balloon, CoronaryCardiopulmonary BypassCause of DeathCoronary Artery BypassCoronary DiseaseCosts and Cost AnalysisFemaleHospital MortalityHumansInternal Mammary-Coronary Artery AnastomosisLength of StayMaleMiddle AgedMinimally Invasive Surgical ProceduresRetrospective StudiesStentsSurvival RateThoracotomyNew-Device Angioplasty in Women: Clinical Outcome and Predictors in a 7,372-Patient Registry
Lansky AJ, Mehran R, Dangas G, Desai K, Costantini-Ortiz C, Cristea E, New G, Negoita M, Stone GW, Leon MB. New-Device Angioplasty in Women: Clinical Outcome and Predictors in a 7,372-Patient Registry. Epidemiology 2002, 13: s46-s51. PMID: 12071484, DOI: 10.1097/00001648-200205001-00010.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsNew device angioplastyClinical outcomesFemale genderHospital mortalityLate mortalityIndependent predictorsMortality rateHospital major adverse cardiac eventsIschemic coronary artery diseaseLong-term clinical outcomesSaphenous vein graft lesionsMultivariable logistic regression analysisDevice-specific outcomesHospital cardiac mortalityLate clinical outcomesAdverse cardiac eventsComorbid risk factorsCongestive heart failureNative coronary arteriesOutcomes of womenVein graft lesionsCoronary artery diseaseReference vessel sizeConventional balloon angioplasty
2001
Effect of gender on the outcomes of contemporary percutaneous coronary intervention
Peterson E, Lansky A, Kramer J, Anstrom K, Lanzilotta M, Investigators F. Effect of gender on the outcomes of contemporary percutaneous coronary intervention. The American Journal Of Cardiology 2001, 88: 359-364. PMID: 11545754, DOI: 10.1016/s0002-9149(01)01679-4.Peer-Reviewed Original ResearchConceptsIndependent risk factorRisk factorsBaseline clinical risk factorsHigher vascular complication ratesContemporary percutaneous coronary interventionPercutaneous coronary intervention (PCI) technologyRisk adjustmentExtensive coronary diseaseProcedural mortality rateVascular complication ratesClinical risk factorsPercutaneous coronary interventionBody surface areaPatient body sizeHospital revascularizationAssociation of genderComorbid illnessesVascular complicationsComplication rateCoronary interventionCoronary diseaseProcedural outcomesFemale genderIndependent riskPCI cases
1999
In-hospital and long-term results of stent deployment compared with balloon angioplasty for treatment of narrowing at the saphenous vein graft distal anastomosis site
Gruberg L, Hong M, Mehran R, Mintz G, Kornowski R, Lansky A, Kent K, Pichard A, Satler L, Dangas G, Wu H, Stone G, Leon M. In-hospital and long-term results of stent deployment compared with balloon angioplasty for treatment of narrowing at the saphenous vein graft distal anastomosis site. The American Journal Of Cardiology 1999, 84: 1381-1384. PMID: 10606108, DOI: 10.1016/s0002-9149(99)00580-9.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsDistal anastomosis siteLong-term outcomesBalloon angioplastyAnastomosis siteQ-wave myocardial infarction rateStent deploymentBalloon angioplasty groupMajor ischemic complicationsBaseline clinical characteristicsTarget lesion revascularizationMyocardial infarction rateProcedural success rateLower restenosis rateLong-term resultsRole of stentsHigh rateAngioplasty groupLesion revascularizationHospital outcomesInfarction rateIschemic complicationsPercutaneous revascularizationRepeat revascularizationClinical characteristics