2013
Predictors of suboptimal TIMI flow after primary angioplasty for acute myocardial infarction: results from the HORIZONS-AMI trial.
Caixeta A, Lansky AJ, Mehran R, Brener SJ, Claessen B, Généreux P, Palmerini T, Witzenbichler B, Guagliumi G, Brodie BR, Dudek D, Fahy M, Dangas GD, Stone GW. Predictors of suboptimal TIMI flow after primary angioplasty for acute myocardial infarction: results from the HORIZONS-AMI trial. EuroIntervention 2013, 9: 220-7. PMID: 23518872, DOI: 10.4244/eijv9i2a37.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryAntithrombinsChi-Square DistributionCoronary AngiographyCoronary CirculationFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPlatelet Aggregation InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeConceptsTIMI 3 flowFinal TIMI 3 flowHORIZONS-AMI trialAcute myocardial infarctionPrimary PCITIMI flowMyocardial infarctionGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsNormal TIMI flowThree-year mortalityMulticentre prospective studyPatient-related factorsBaseline TIMIAngiographic factorsPrimary angioplastyIndependent predictorsUnfractionated heparinProspective studyAnterior MIAnatomical factorsPatientsTIMICore labLesion length
2012
Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial
Rosenberg S, Elashoff MR, Lieu HD, Brown BO, Kraus WE, Schwartz RS, Voros S, Ellis SG, Waksman R, McPherson JA, Lansky AJ, Topol EJ, for the PREDICT Investigators. Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial. Journal Of Cardiovascular Translational Research 2012, 5: 366-374. PMID: 22396313, PMCID: PMC3349850, DOI: 10.1007/s12265-012-9353-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenetic TestingHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPhenotypePredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsStrokeTime FactorsUnited StatesConceptsMajor adverse cardiovascular eventsCoronary artery diseaseObstructive coronary artery diseaseGene expression scoreAdverse cardiovascular eventsCardiovascular eventsArtery diseaseClinical risk scoreGroup of patientsNegative predictive valueGene expression testingNondiabetic patientsPREDICT trialAngiography patientsGES groupPREDICT studyRisk scorePatientsPredictive valueExpression scoreRevascularizationEvent ratesDiseaseMonthsExpression testingGender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes
Lansky AJ, Ng VG, Maehara A, Weisz G, Lerman A, Mintz GS, De Bruyne B, Farhat N, Niess G, Jankovic I, Lazar D, Xu K, Fahy M, Serruys PW, Stone GW. Gender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s62-s72. PMID: 22421232, DOI: 10.1016/j.jcmg.2012.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleFibrosisHeart ArrestHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsThin-cap fibroatheromaSimilar plaque burdenAcute coronary syndromePlaque burdenNonculprit lesionsCoronary syndromePlaque rupturePlaque compositionExtensive coronary artery diseaseMajor adverse cardiovascular eventsAcute coronary syndrome eventPROSPECT studyComposition of atherosclerosisNecrotic core volumeThick-cap fibroatheromaUntreated nonculprit lesionsAdverse cardiovascular eventsComorbid risk factorsCoronary artery diseaseMinimal lumen areaSex-based subgroup analysisPathological intimal thickeningCardiovascular eventsMultivariable adjustmentComorbid diseasesResidual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention
McPherson JA, Maehara A, Weisz G, Mintz GS, Cristea E, Mehran R, Foster M, Verheye S, Rabbani L, Xu K, Fahy M, Templin B, Zhang Z, Lansky AJ, de Bruyne B, Serruys PW, Stone GW. Residual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention. JACC Cardiovascular Imaging 2012, 5: s76-s85. PMID: 22421234, DOI: 10.1016/j.jcmg.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsMajor adverse cardiovascular eventsSuccessful percutaneous coronary interventionPercutaneous coronary interventionAcute coronary syndromePlaque burdenThin-cap fibroatheromaNonculprit lesionsIntravascular ultrasoundCardiovascular eventsCoronary syndromeCoronary interventionAtherosclerotic diseaseSignificant lesionsFuture major adverse cardiovascular eventsPrior percutaneous coronary interventionMean diameter stenosisMean plaque burdenPercent plaque volumeResidual plaque burdenUntreated nonculprit lesionsAdverse cardiovascular eventsFuture cardiovascular eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundAtherosclerotic burden
2011
Impact of Bleeding on Mortality After Percutaneous Coronary Intervention Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials
Mehran R, Pocock S, Nikolsky E, Dangas GD, Clayton T, Claessen BE, Caixeta A, Feit F, Manoukian SV, White H, Bertrand M, Ohman EM, Parise H, Lansky AJ, Lincoff AM, Stone GW. Impact of Bleeding on Mortality After Percutaneous Coronary Intervention Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials. JACC Cardiovascular Interventions 2011, 4: 654-664. PMID: 21700252, DOI: 10.1016/j.jcin.2011.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAntithrombinsConfidence IntervalsCoronary Artery DiseaseDrug-Eluting StentsFemaleHealth Status IndicatorsHemorrhageHeparinHirudinsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial ReperfusionPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexRandomized Controlled Trials as TopicRecombinant ProteinsRisk AssessmentRisk FactorsTriageConceptsPercutaneous coronary interventionTIMI major bleedingPatient-level pooled analysisHORIZONS-AMI trialMajor bleedingBlood transfusionSubsequent mortalityRisk scoreHazard ratioIndependent predictorsPooled analysisGlycoprotein IIb/IIIa inhibitorsPercutaneous Coronary Intervention ResultsIIb/IIIa inhibitorsMajor bleeding ratesTIMI major bleedTIMI minor bleedingRespective hazard ratiosArtery bypass graftRisk score groupsHigh-risk groupRisk of patientsIsolated hematomasMajor bleedsLate mortalityThe Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Wu X, Mintz GS, Xu K, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Dressler O, Parise H, Mehran R, Stone GW, Maehara A. The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2011, 4: 495-502. PMID: 21596321, DOI: 10.1016/j.jcin.2010.12.012.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary CirculationEuropeHumansLogistic ModelsMulticenter Studies as TopicMyocardial InfarctionNo-Reflow PhenomenonPlaque, AtheroscleroticPredictive Value of TestsRandomized Controlled Trials as TopicRetrospective StudiesRisk AssessmentRisk FactorsStentsStroke VolumeTreatment OutcomeUltrasonography, InterventionalUnited StatesVentricular Function, LeftConceptsAcute myocardial infarctionAttenuated plaqueHORIZONS-AMI trialPercutaneous coronary interventionMyocardial infarctionAttenuation scoreIntravascular ultrasoundVentricular ejection fractionGrayscale intravascular ultrasoundAngiographic thrombusFinal ThrombolysisCoronary interventionDistal embolizationEjection fractionMechanical obstructionTransient deteriorationCoronary flowStent implantationNo-ReflowPatientsMultivariate analysisLower baselineStent expansionInfarctionPlaquesLong-Term (Three-Year) Safety and Efficacy of Everolimus-Eluting Stents Compared to Paclitaxel-Eluting Stents (from the SPIRIT III Trial)
Applegate RJ, Yaqub M, Hermiller JB, Sood P, Yu S, Doostzadeh J, Williams JE, Farhat N, Caputo R, Lansky AJ, Cutlip DE, Sudhir K, Stone GW. Long-Term (Three-Year) Safety and Efficacy of Everolimus-Eluting Stents Compared to Paclitaxel-Eluting Stents (from the SPIRIT III Trial). The American Journal Of Cardiology 2011, 107: 833-840. PMID: 21247538, DOI: 10.1016/j.amjcard.2010.10.069.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisCoronary ThrombosisDrug-Eluting StentsEverolimusFemaleFollow-Up StudiesHumansImmunosuppressive AgentsLogistic ModelsMaleMiddle AgedPaclitaxelProspective StudiesSingle-Blind MethodSirolimusSurvival RateTreatment OutcomeTubulin ModulatorsUnited StatesConceptsPaclitaxel-eluting stentsMajor adverse cardiovascular eventsSPIRIT III trialAdverse cardiovascular eventsCardiovascular eventsIII trialsPrimary clinical end pointLimited long-term dataTarget lesion revascularizationTarget vessel failureEvent-free survivalClinical end pointsEverolimus-Eluting StentsLong-term safetyLesion revascularizationCardiac deathCoronary arteryMyocardial infarctionSPIRIT IIClinical trialsEfficacy profileUnited States sitesLandmark analysisTerm safetyXIENCE V
2010
Clinical Follow-Up 3 Years After Everolimus- and Paclitaxel-Eluting Stents A Pooled Analysis From the SPIRIT II (A Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) and SPIRIT III (A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) Randomized Trials
Caixeta A, Lansky AJ, Serruys PW, Hermiller JB, Ruygrok P, Onuma Y, Gordon P, Yaqub M, Miquel-Hebert K, Veldhof S, Sood P, Su X, Jonnavithula L, Sudhir K, Stone GW, Investigators S. Clinical Follow-Up 3 Years After Everolimus- and Paclitaxel-Eluting Stents A Pooled Analysis From the SPIRIT II (A Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) and SPIRIT III (A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) Randomized Trials. JACC Cardiovascular Interventions 2010, 3: 1220-1228. PMID: 21232715, DOI: 10.1016/j.jcin.2010.07.017.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAntineoplastic Agents, PhytogenicAspirinClopidogrelConfidence IntervalsCoronary Artery DiseaseDrug-Eluting StentsEverolimusFemaleFollow-Up StudiesHumansImmunosuppressive AgentsKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedPaclitaxelPlatelet Aggregation InhibitorsProportional Hazards ModelsRandomized Controlled Trials as TopicRiskRisk Reduction BehaviorSirolimusTiclopidineTime FactorsConceptsMajor adverse cardiac eventsPaclitaxel-eluting stentsAdverse cardiac eventsTarget vessel failureCardiac eventsMyocardial infarctionSPIRIT IIProbable stent thrombosisAcademic Research ConsortiumEverolimus-eluting stentsVessel failureSignificant reductionLesion revascularizationPES patientsRevascularization eventsIII trialsClinical outcomesEE patientsStent thrombosisPooled analysisCumulative ratePersistent reductionSPIRIT IIIPatientsStentsSurgical Versus Percutaneous Revascularization for Multivessel Disease in Patients With Acute Coronary Syndromes Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial
Ben-Gal Y, Moses JW, Mehran R, Lansky AJ, Weisz G, Nikolsky E, Argenziano M, Williams MR, Colombo A, Aylward PE, Stone GW. Surgical Versus Percutaneous Revascularization for Multivessel Disease in Patients With Acute Coronary Syndromes Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial. JACC Cardiovascular Interventions 2010, 3: 1059-1067. PMID: 20965465, DOI: 10.1016/j.jcin.2010.06.017.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAcute Kidney InjuryAgedAngioplasty, Balloon, CoronaryBlood TransfusionCoronary AngiographyCoronary Artery BypassFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPropensity ScoreRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionAcute coronary syndromeHigh-risk patientsMultivessel diseaseACUITY trialRenal injuryMyocardial infarctionHigh-risk acute coronary syndromesAcute Coronary Syndromes AnalysisHigh-risk ACS patientsMultivessel coronary artery diseasePeri-procedural strokePreferred revascularization strategyPropensity-matched comparisonPropensity-matched patientsAcute renal injuryCoronary artery bypassOutcomes of patientsMore blood transfusionsCoronary artery diseaseRepeat revascularization proceduresACS patientsMajor bleedingPCI groupUnplanned revascularizationEverolimus-Eluting versus Paclitaxel-Eluting Stents in Coronary Artery Disease
Stone GW, Rizvi A, Newman W, Mastali K, Wang JC, Caputo R, Doostzadeh J, Cao S, Simonton CA, Sudhir K, Lansky AJ, Cutlip DE, Kereiakes DJ. Everolimus-Eluting versus Paclitaxel-Eluting Stents in Coronary Artery Disease. New England Journal Of Medicine 2010, 362: 1663-1674. PMID: 20445180, DOI: 10.1056/nejmoa0910496.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsTarget lesion failureEverolimus-eluting stentsMajor secondary end pointPrimary end pointSecondary end pointsEnd pointMyocardial infarctionIschemia-driven target lesion revascularizationRoutine follow-up angiographyTarget vessel myocardial infarctionComposite rateTarget lesion revascularizationClinical end pointsCoronary artery diseaseSubgroup of patientsFollow-up angiographyEverolimus-ElutingAngiographic findingsPrespecified subgroupsArtery diseaseCardiac deathStent thrombosisPatientsStents
2009
Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications
Pocock SJ, Mehran R, Clayton TC, Nikolsky E, Parise H, Fahy M, Lansky AJ, Bertrand ME, Lincoff AM, Moses JW, Ohman EM, White HD, Stone GW. Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications. Circulation 2009, 121: 43-51. PMID: 20026777, DOI: 10.1161/circulationaha.109.878017.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overFemaleFibrinolytic AgentsHemorrhageHeparinHirudinsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial IschemiaPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexPredictive Value of TestsPrognosisRandomized Controlled Trials as TopicRecombinant ProteinsRetrospective StudiesRisk FactorsConceptsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsIndividual patient risk profileAcute coronary syndromePatient risk profileMajor bleedingMyocardial infarctionCoronary syndromeRisk profileHemorrhagic complicationsIndependent predictorsMortality rateUrgent Intervention Triage Strategy (ACUITY) trialAlternative antithrombotic regimensIndividual patient's riskRisk of deathCox regression modelTherapy of patientsSubsequent mortality ratesRelative treatment effectsAcute CatheterizationAntithrombotic regimensMajor bleedsAlternative pharmacotherapyStrategy trialIntravascular Ultrasound Assessment of the Incidence and Predictors of Edge Dissections After Drug-Eluting Stent Implantation
Liu X, Tsujita K, Maehara A, Mintz GS, Weisz G, Dangas GD, Lansky AJ, Kreps EM, Rabbani LE, Collins M, Stone GW, Moses JW, Mehran R, Leon MB. Intravascular Ultrasound Assessment of the Incidence and Predictors of Edge Dissections After Drug-Eluting Stent Implantation. JACC Cardiovascular Interventions 2009, 2: 997-1004. PMID: 19850262, DOI: 10.1016/j.jcin.2009.07.012.Peer-Reviewed Original ResearchConceptsStent edge dissectionEdge dissectionDES implantationPlaque eccentricityIntravascular ultrasoundIntramural hematomaPlaque burdenStent implantationStent edgeDrug-Eluting Stent ImplantationDistal stent edgeStent restenosis lesionsBare-metal stentingIntravascular ultrasound assessmentResidual plaque areaCoronary dissectionRestenosis lesionsAngiographic findingsIndependent predictorsHematoma groupResidual plaqueUltrasound assessmentDissection groupPlaque areaNondissection groupIntravascular Ultrasound Comparison of the Retrograde Versus Antegrade Approach to Percutaneous Intervention for Chronic Total Coronary Occlusions
Tsujita K, Maehara A, Mintz GS, Kubo T, Doi H, Lansky AJ, Stone GW, Moses JW, Leon MB, Ochiai M. Intravascular Ultrasound Comparison of the Retrograde Versus Antegrade Approach to Percutaneous Intervention for Chronic Total Coronary Occlusions. JACC Cardiovascular Interventions 2009, 2: 846-854. PMID: 19778773, DOI: 10.1016/j.jcin.2009.06.012.Peer-Reviewed Original ResearchConceptsRetrograde approachRetro groupAntegrade approachMyocardial Infarction flow grade 3Chronic total occlusion techniqueChronic total coronary occlusionsIntravascular Ultrasound ComparisonTotal coronary occlusionMinimum stent areaAngiographic extravasationRCA CTOsIntravascular ultrasound imagingCoronary perforationCTO lengthCTO lesionsCoronary occlusionCTO interventionGuidewire crossingPercutaneous interventionUltrasound comparisonCTO segmentGrade 3Stent areaOcclusion techniqueIntravascular ultrasoundImpact of Chronic Kidney Disease on Early (30-Day) and Late (1-Year) Outcomes of Patients With Acute Coronary Syndromes Treated With Alternative Antithrombotic Treatment Strategies An ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Substudy
Mehran R, Nikolsky E, Lansky AJ, Kirtane AJ, Kim YH, Feit F, Manoukian S, Moses JW, Ebrahimi R, Ohman EM, White HD, Pocock SJ, Dangas GD, Stone GW. Impact of Chronic Kidney Disease on Early (30-Day) and Late (1-Year) Outcomes of Patients With Acute Coronary Syndromes Treated With Alternative Antithrombotic Treatment Strategies An ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Substudy. JACC Cardiovascular Interventions 2009, 2: 748-757. PMID: 19695543, DOI: 10.1016/j.jcin.2009.05.018.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryBiomarkersChronic DiseaseCoronary Artery BypassCreatinineDrug Therapy, CombinationFemaleFibrinolytic AgentsHemorrhageHeparinHirudinsHumansKidney DiseasesLogistic ModelsMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaOdds RatioPeptide FragmentsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecombinant ProteinsRisk AssessmentTime FactorsTreatment OutcomeTriageConceptsGlycoprotein IIb/IIIa inhibitorsChronic kidney diseaseAcute coronary syndromeBivalirudin monotherapyComposite ischemiaMajor bleedingCoronary syndromeClinical outcomesKidney diseaseHigh-risk acute coronary syndromesIIb/IIIa inhibitorsClinical adverse outcomesCreatinine clearance dataOutcomes of patientsNormal renal functionAdverse event ratesAntithrombotic treatment strategiesSignificant differencesACUITY trialIschemic outcomesRenal functionAdverse outcomesInvasive strategyLate outcomesTreatment strategiesGender‐based evaluation of the XIENCE V™ everolimus‐eluting coronary stent system:
Lansky AJ, Ng VG, Mutlu H, Cristea E, Guiran JB, Midei M, Newman W, Sanz M, Sood P, Doostzadeh J, Su X, White R, Cao S, Sudhir K, Stone GW. Gender‐based evaluation of the XIENCE V™ everolimus‐eluting coronary stent system:. Catheterization And Cardiovascular Interventions 2009, 74: 719-727. PMID: 19530147, DOI: 10.1002/ccd.22067.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiovascular AgentsCardiovascular DiseasesCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisDrug-Eluting StentsEverolimusFemaleHumansKaplan-Meier EstimateLinear ModelsLogistic ModelsMaleMiddle AgedMyocardial InfarctionPaclitaxelProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsSex FactorsSingle-Blind MethodSirolimusThrombosisTime FactorsTreatment OutcomeWomen's HealthConceptsSPIRIT III trialIII trialsXIENCE VTaxus stentXience V stentTVF rateTAXUS paclitaxel-eluting stentRate of MACECoronary artery lesionsStent thrombosis ratesPercutaneous coronary interventionStent late lossPaclitaxel-eluting stentsCoronary stent systemHigher MACEMore hypertensionAngiographic characteristicsArtery lesionsCoronary interventionThrombosis rateAngiographic resultsClinical outcomesClinical benefitStent placementSubset analysis
2008
Comparison of an Everolimus-Eluting Stent and a Paclitaxel-Eluting Stent in Patients With Coronary Artery Disease: A Randomized Trial
Stone GW, Midei M, Newman W, Sanz M, Hermiller JB, Williams J, Farhat N, Mahaffey KW, Cutlip DE, Fitzgerald PJ, Sood P, Su X, Lansky AJ, Investigators F. Comparison of an Everolimus-Eluting Stent and a Paclitaxel-Eluting Stent in Patients With Coronary Artery Disease: A Randomized Trial. JAMA 2008, 299: 1903-1913. PMID: 18430909, DOI: 10.1001/jama.299.16.1903.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisDrug-Eluting StentsEverolimusFemaleHumansImmunosuppressive AgentsLogistic ModelsMaleMiddle AgedMyocardial InfarctionPaclitaxelProspective StudiesSingle-Blind MethodSirolimusUltrasonography, InterventionalConceptsMajor adverse cardiac eventsAdverse cardiac eventsPaclitaxel-eluting stentsSegment late lossSecondary end pointsTarget vessel failureCoronary artery diseaseCardiac eventsLate lossEnd pointArtery diseaseComposite major adverse cardiac eventsAdditional secondary end pointsMajor secondary end pointLesion revascularization proceduresSPIRIT III trialPrimary end pointReference vessel diameterPercutaneous coronary interventionEverolimus-Eluting StentsAngiographic late lossCobalt-chromium stentAgents everolimusNoninferior ratesAngiographic outcomes
2005
Intravascular Ultrasound Study of Patterns of Calcium in Ruptured Coronary Plaques
Fujii K, Carlier SG, Mintz GS, Takebayashi H, Yasuda T, Costa RA, Moussa I, Dangas G, Mehran R, Lansky AJ, Kreps EM, Collins M, Stone GW, Moses JW, Leon MB. Intravascular Ultrasound Study of Patterns of Calcium in Ruptured Coronary Plaques. The American Journal Of Cardiology 2005, 96: 352-357. PMID: 16054456, DOI: 10.1016/j.amjcard.2005.03.074.Peer-Reviewed Original ResearchConceptsRuptured plaquesControl plaquesCalcium depositsCoronary calciumSuperficial calciumLarge calcium depositsLumen cross-sectional areaMinimum lumen cross-sectional areaRuptured coronary plaquesIntravascular ultrasound studyArc of calciumAtherosclerotic plaque developmentDeep calciumCoronary plaquesSmall calcium depositsPlaque instabilityPlaque ruptureUltrasound studyPlaque developmentPlaquesCross-sectional areaLess calciumCalciumLong segmentGroup
2004
A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation
MEHRAN R, AYMONG E, NIKOLSKY E, LASIC Z, IAKOVOU I, FAHY M, MINTZ G, LANSKY A, MOSES J, STONE G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation. Journal Of The American College Of Cardiology 2004, 44: 1393-1399. DOI: 10.1016/s0735-1097(04)01445-7.Peer-Reviewed Original ResearchA simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention Development and initial validation
Mehran R, Aymong E, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz G, Lansky A, Moses J, Stone G, Leon M, Dangas G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention Development and initial validation. Journal Of The American College Of Cardiology 2004, 44: 1393-1399. PMID: 15464318, DOI: 10.1016/j.jacc.2004.06.068.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyPercutaneous coronary interventionSimple risk scoreRisk scoreRate of CINRisk of CINCandidate univariate predictorsMultivariate logistic regressionTotal risk scoreGood discriminative powerWeighted integerCoronary interventionIndependent predictorsUnivariate predictorsRisk factorsOdds ratioProcedural characteristicsCumulative riskPatientsLogistic regressionIntervention developmentOverall occurrenceInvestigational purposesNephropathyScoresPrognostic significance of cerebrovascular and peripheral arterial disease in patients having percutaneous coronary interventions
Nikolsky E, Mehran R, Dangas GD, Lasic Z, Mintz GS, Negoita M, Lansky AJ, Stone GW, Moussa I, Iyer S, Na Y, Moses JW, Leon MB. Prognostic significance of cerebrovascular and peripheral arterial disease in patients having percutaneous coronary interventions. The American Journal Of Cardiology 2004, 93: 1536-1539. PMID: 15194030, DOI: 10.1016/j.amjcard.2004.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryBody Mass IndexCase-Control StudiesCerebrovascular DisordersCoronary Artery DiseaseDiabetes ComplicationsFemaleHospital MortalityHumansKidney Failure, ChronicLength of StayLogistic ModelsMaleMiddle AgedMultivariate AnalysisPeripheral Vascular DiseasesPrognosisSaphenous VeinSex Factors