2016
TCT-94 Impact of Thin-Cap Fibroatheromas on Unanticipated Ischemic Events in Medically Treated Patients With Diabetes Mellitus: Insights From the PROSPECT Study
Kedhi E, Kennedy M, Maehara A, Lansky A, McAndrew T, Marso S, De Bruyne B, Serruys P, Stone G. TCT-94 Impact of Thin-Cap Fibroatheromas on Unanticipated Ischemic Events in Medically Treated Patients With Diabetes Mellitus: Insights From the PROSPECT Study. Journal Of The American College Of Cardiology 2016, 68: b38-b39. DOI: 10.1016/j.jacc.2016.09.359.Peer-Reviewed Original ResearchThin-cap fibroatheromaIschemic eventsDiabetes mellitusPROSPECT studyMellitusFibroatheromaPatientsMedicallyImpact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study
Kedhi E, Kennedy MW, Maehara A, Lansky AJ, McAndrew TC, Marso SP, De Bruyne B, Serruys PW, Stone GW. Impact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study. JACC Cardiovascular Imaging 2016, 10: 451-458. PMID: 27372016, DOI: 10.1016/j.jcmg.2015.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDiabetes MellitusDisease ProgressionFemaleFibrosisHumansMaleMiddle AgedPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsPropensity ScoreRisk FactorsRupture, SpontaneousTime FactorsTreatment OutcomeUltrasonography, InterventionalConceptsMajor adverse cardiac eventsAcute coronary syndromeThin-cap fibroatheromaNonculprit lesionsDiabetes mellitusACS patientsDM patientsSubsequent major adverse cardiac eventsPresence of DMPROSPECT studyAdverse cardiac eventsPropensity-matched groupsRadiofrequency intravascular ultrasoundHigh rateCoronary syndromeCardiac eventsPlaque compositionIntravascular ultrasoundPatientsPropensity scoreBalanced groupsIschemicMellitusFibroatheromaPrognosis
2012
Residual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention
McPherson JA, Maehara A, Weisz G, Mintz GS, Cristea E, Mehran R, Foster M, Verheye S, Rabbani L, Xu K, Fahy M, Templin B, Zhang Z, Lansky AJ, de Bruyne B, Serruys PW, Stone GW. Residual Plaque Burden in Patients With Acute Coronary Syndromes After Successful Percutaneous Coronary Intervention. JACC Cardiovascular Imaging 2012, 5: s76-s85. PMID: 22421234, DOI: 10.1016/j.jcmg.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsMajor adverse cardiovascular eventsSuccessful percutaneous coronary interventionPercutaneous coronary interventionAcute coronary syndromePlaque burdenThin-cap fibroatheromaNonculprit lesionsIntravascular ultrasoundCardiovascular eventsCoronary syndromeCoronary interventionAtherosclerotic diseaseSignificant lesionsFuture major adverse cardiovascular eventsPrior percutaneous coronary interventionMean diameter stenosisMean plaque burdenPercent plaque volumeResidual plaque burdenUntreated nonculprit lesionsAdverse cardiovascular eventsFuture cardiovascular eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundAtherosclerotic burdenDefinitions and Methodology for the Grayscale and Radiofrequency Intravascular Ultrasound and Coronary Angiographic Analyses
Maehara A, Cristea E, Mintz GS, Lansky AJ, Dressler O, Biro S, Templin B, Virmani R, de Bruyne B, Serruys PW, Stone GW. Definitions and Methodology for the Grayscale and Radiofrequency Intravascular Ultrasound and Coronary Angiographic Analyses. JACC Cardiovascular Imaging 2012, 5: s1-s9. PMID: 22421222, DOI: 10.1016/j.jcmg.2011.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDisease ProgressionEuropeFemaleFibrosisHumansImage Processing, Computer-AssistedMaleMiddle AgedMultivariate AnalysisNeointimaPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTerminology as TopicTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsThin-cap fibroatheromaAdverse cardiovascular eventsRadiofrequency intravascular ultrasoundNatural history studiesNonculprit lesionsPlaque burdenCardiovascular eventsLuminal areaIntravascular ultrasoundVH thin-cap fibroatheromaMajor adverse cardiovascular eventsFuture adverse cardiovascular eventsCoronary angiographic analysisCoronary artery ostiumThick-cap fibroatheromaLarger plaque burdenVirtual histologyMinimal luminal areaPathological intimal thickeningSmall luminal areaCoronary artery imagingHistory studiesSide branchesCoronary atherosclerosisCulprit lesionCharacteristics and Clinical Significance of Angiographically Mild Lesions in Acute Coronary Syndromes
Brener SJ, Mintz GS, Cristea E, Weisz G, Maehara A, McPherson JA, Marso SP, Farhat N, Botker HE, Dressler O, Xu K, Templin B, Zhang Z, Lansky AJ, de Bruyne B, Serruys PW, Stone GW. Characteristics and Clinical Significance of Angiographically Mild Lesions in Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s86-s94. PMID: 22421235, DOI: 10.1016/j.jcmg.2011.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleFibrosisHumansKaplan-Meier EstimateMaleMiddle AgedNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecurrenceRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsAcute coronary syndromePercutaneous coronary interventionMajor adverse cardiac eventsAdverse cardiac eventsCoronary syndromeNC lesionsCoronary interventionCardiac eventsDiameter stenosisSuccessful percutaneous coronary interventionMedian diameter stenosisRecurrent ischemic eventsThin-cap fibroatheromaNonculprit lesionsIschemic eventsUntreated lesionsClinical eventsClinical significanceMild lesionsPatientsLesionsNormal segmentsOne-halfSyndromeRecurrent eventsGender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes
Lansky AJ, Ng VG, Maehara A, Weisz G, Lerman A, Mintz GS, De Bruyne B, Farhat N, Niess G, Jankovic I, Lazar D, Xu K, Fahy M, Serruys PW, Stone GW. Gender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s62-s72. PMID: 22421232, DOI: 10.1016/j.jcmg.2012.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleFibrosisHeart ArrestHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsThin-cap fibroatheromaSimilar plaque burdenAcute coronary syndromePlaque burdenNonculprit lesionsCoronary syndromePlaque rupturePlaque compositionExtensive coronary artery diseaseMajor adverse cardiovascular eventsAcute coronary syndrome eventPROSPECT studyComposition of atherosclerosisNecrotic core volumeThick-cap fibroatheromaUntreated nonculprit lesionsAdverse cardiovascular eventsComorbid risk factorsCoronary artery diseaseMinimal lumen areaSex-based subgroup analysisPathological intimal thickeningCardiovascular eventsMultivariable adjustmentComorbid diseases
2011
A Prospective Natural-History Study of Coronary Atherosclerosis
Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, Mehran R, McPherson J, Farhat N, Marso SP, Parise H, Templin B, White R, Zhang Z, Serruys PW. A Prospective Natural-History Study of Coronary Atherosclerosis. New England Journal Of Medicine 2011, 364: 226-235. PMID: 21247313, DOI: 10.1056/nejmoa1002358.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDisease ProgressionFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPatient ReadmissionProportional Hazards ModelsProspective StudiesRecurrenceRisk FactorsUltrasonography, InterventionalConceptsMajor adverse cardiovascular eventsAdverse cardiovascular eventsAcute coronary syndromeNonculprit lesionsPercutaneous coronary interventionThin-cap fibroatheromaCardiovascular eventsCoronary syndromeCulprit lesionCoronary interventionPlaque burdenIntravascular ultrasonographyLuminal areaSubsequent major adverse cardiovascular eventsLesion-related risk factorsMild coronary artery stenosisProspective natural history studyLarger plaque burdenCoronary artery stenosisMinimal luminal areaNatural history studiesRecurrent eventsSmall luminal areaMedian followCoronary atherosclerosis