2013
Drug-eluting balloon angioplasty for in-stent restenosis: a systematic review and meta-analysis of randomised controlled trials
Indermuehle A, Bahl R, Lansky AJ, Froehlich GM, Knapp G, Timmis A, Meier P. Drug-eluting balloon angioplasty for in-stent restenosis: a systematic review and meta-analysis of randomised controlled trials. Heart 2013, 99: 327. PMID: 23335497, DOI: 10.1136/heartjnl-2012-302945.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsDrug-eluting balloonsDrug-eluting balloon angioplastyBalloon angioplastyStent restenosisStent thrombosisMyocardial infarctionRelative riskSegment restenosisTreatment optionsSystematic reviewIncidence of MIRisk of STAdverse cardiac eventsPooled relative riskPlain balloon angioplastyOptimal treatment optionsPromising treatment optionDrug-eluting stentsRandom-effects modelLesion revascularisationCardiac eventsCoronary angioplastyMain endpointClinical trials
2006
Usefulness of Routine Unfractionated Heparin Infusion Following Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients Not Receiving Glycoprotein IIb/IIIa Inhibitors
Harjai KJ, Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Na Y, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Rutherford BD, Lansky AJ, Mehran R. Usefulness of Routine Unfractionated Heparin Infusion Following Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients Not Receiving Glycoprotein IIb/IIIa Inhibitors. The American Journal Of Cardiology 2006, 99: 202-207. PMID: 17223419, DOI: 10.1016/j.amjcard.2006.07.084.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyPrimary percutaneous coronary interventionGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsAcute myocardial infarctionPercutaneous coronary interventionHeparin usePostprocedural heparinCoronary interventionMyocardial infarctionHospital major adverse cardiac eventsPrimary PCIMajor adverse cardiac eventsUnfractionated heparin infusionAdverse cardiac eventsOutcomes of patientsSubset of patientsTransluminal coronary angioplastyLate MACEPostprocedure courseHeparin infusionCardiac eventsCoronary angioplastyCoronary stentingSevere bleedingImpact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: Analysis from the CADILLAC trial
Brodie BR, Stone GW, Cox DA, Stuckey TD, Turco M, Tcheng JE, Berger P, Mehran R, McLaughlin M, Costantini C, Lansky AJ, Grines CL. Impact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: Analysis from the CADILLAC trial. American Heart Journal 2006, 151: 1231-1238. PMID: 16781224, DOI: 10.1016/j.ahj.2005.07.016.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionAcute myocardial infarctionLow-risk patientsLeft ventricular functionOnset of symptomsTreatment delayCoronary interventionEarly reperfusionMyocardial infarctionCADILLAC trialVentricular functionComplete ST-segment resolutionPercutaneous transluminal coronary angioplastyFrequent grade 2ST-segment resolutionHigh-risk patientsSuperior clinical outcomesTransluminal coronary angioplastyMicrovascular reperfusionBalloon timeCoronary angioplastyClinical outcomesMyocardial blushPatient triage
2004
Influence of admission and discharge aspirin use on survival after primary coronary angioplasty for acute myocardial infarction
Kandzari DE, Tcheng JE, Grines CL, Cox DA, Stuckey T, Griffin JJ, Turco M, Garcia E, Carroll JD, Fahy M, Lansky AJ, Mehran R, Stone GW, Investigators C. Influence of admission and discharge aspirin use on survival after primary coronary angioplasty for acute myocardial infarction. The American Journal Of Cardiology 2004, 94: 1029-1033. PMID: 15476618, DOI: 10.1016/j.amjcard.2004.06.060.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAspirin useMyocardial infarctionPrimary percutaneous coronary interventionInfluence of admissionPrimary coronary angioplastyProspective multicenter trialPercutaneous coronary interventionTime of admissionCoronary interventionCoronary angioplastyMulticenter trialInfarctionAdmissionAngioplastyPatientsTrials
2003
Comparison of effect of glycoprotein IIb/IIIa inhibitors during percutaneous coronary interventions on risk of hemorrhagic stroke in patients ≥75 years of age versus those <75 years of age
Iakovou I, Dangas G, Mehran R, Mintz GS, Lansky AJ, Aymong ED, Nikolsky E, Vagaonescu T, Glasser LA, Stone GW, Leon MB, Moses JW. Comparison of effect of glycoprotein IIb/IIIa inhibitors during percutaneous coronary interventions on risk of hemorrhagic stroke in patients ≥75 years of age versus those <75 years of age. The American Journal Of Cardiology 2003, 92: 1083-1086. PMID: 14583360, DOI: 10.1016/j.amjcard.2003.07.007.Peer-Reviewed Original ResearchOutcomes of optimal or “stent-like”balloon angioplasty in acutemyocardial infarction: the CADILLAC trial
Cox DA, Stone GW, Grines CL, Stuckey T, Cohen DJ, Tcheng JE, Garcia E, Guagliumi G, Iwaoka RS, Fahy M, Turco M, Lansky AJ, Griffin JJ, Mehran R, Investigators C. Outcomes of optimal or “stent-like”balloon angioplasty in acutemyocardial infarction: the CADILLAC trial. Journal Of The American College Of Cardiology 2003, 42: 971-977. PMID: 13678914, DOI: 10.1016/s0735-1097(03)00911-2.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyAcute myocardial infarctionTarget vessel revascularizationIschemic target vessel revascularizationRoutine stentingRoutine stent placementStent implantationStent placementPrimary percutaneous transluminal coronary angioplastyComposite adverse event rateLate Angioplasty Complications (CADILLAC) trialRoutine stent implantationAdverse event ratesTransluminal coronary angioplastyRelevant treatment modalitiesRate of deathCADILLAC trialControlled AbciximabEligible lesionsAngiographic restenosisVessel revascularizationComplications TrialCoronary angioplastyDiameter stenosisPTCA results
2002
Comparison of Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction
Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Carroll JD, Rutherford BD, Lansky AJ. Comparison of Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction. New England Journal Of Medicine 2002, 346: 957-966. PMID: 11919304, DOI: 10.1056/nejmoa013404.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCombined Modality TherapyCoronary AngiographyFemaleHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecurrenceStentsStrokeConceptsPrimary percutaneous transluminal coronary angioplastyAcute myocardial infarctionPercent of patientsPrimary end pointInfarct-related arteryRate of deathMyocardial infarctionAbciximab therapyReperfusion strategyPlatelet glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsTarget vesselIIb/IIIa inhibitorsPercutaneous transluminal coronary angioplastyEnd pointComposite of deathTarget vessel revascularizationIschemia-driven revascularizationTransluminal coronary angioplastyComparison of AngioplastyAbciximab useRecurrent ischemiaExperienced centersCoronary angioplastyCoronary stentingDevice selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials)
Ajani AE, Waksman R, Zimarino M, Kim H, Pichard AD, Satler LF, Kent KM, White RL, Pinnow E, Mehran R, Lansky A, Lindsay J. Device selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials). The American Journal Of Cardiology 2002, 89: 137-144. PMID: 11792331, DOI: 10.1016/s0002-9149(01)02189-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplastyAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary DiseaseDose-Response Relationship, RadiationFemaleHumansIridium RadioisotopesLogistic ModelsMaleMiddle AgedProspective StudiesRisk FactorsSecondary PreventionStentsTreatment OutcomeVascular PatencyConceptsExcimer laser coronary angioplastyMajor adverse coronary eventsAdditional stent implantationTreatment of ISRRecurrence rateCoronary angioplastyRotational atherectomyStent implantationStent restenosisBalloon percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyIntracoronary gamma radiationLate clinical outcomesAdverse coronary eventsOverall recurrence rateTransluminal coronary angioplastyLaser coronary angioplastyHigh recurrence rateUse of stentingDevice selectionAngiographic characteristicsMACE ratePlacebo groupPlacebo therapyCoronary events
2001
Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial)
Brodie B, Stone G, Morice M, Cox D, Garcia E, Mattos L, Boura J, O’Neill W, Stuckey T, Milks S, Lansky A, Grines C, Group F. Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial). The American Journal Of Cardiology 2001, 88: 1085-1090. PMID: 11703949, DOI: 10.1016/s0002-9149(01)02039-2.Peer-Reviewed Original ResearchConceptsPrimary percutaneous transluminal coronary angioplastyPrimary PTCAAcute myocardial infarctionCardiogenic shockCoronary angioplastyMyocardial infarctionMyocardial Infarction (TIMI) grade 3 flowPercutaneous transluminal coronary angioplastyInfarct artery reocclusionStent-PAMI trialGrade 3 flowPrimary coronary angioplastyTransluminal coronary angioplastyTriage of patientsArtery reocclusionMortality benefitSurvival benefitEjection fractionLate reperfusionClinical outcomesMyocardial salvageThrombolytic therapyReperfusionPatientsLack of correlationTreatment of focal in-stent restenosis with balloon angioplasty alone versus stenting: Short- and long-term results
Mehran R, Dangas G, Abizaid A, Lansky A, Mintz G, Pichard A, Satler L, Kent K, Waksman R, Stone G, Leon M. Treatment of focal in-stent restenosis with balloon angioplasty alone versus stenting: Short- and long-term results. American Heart Journal 2001, 141: 610-614. PMID: 11275928, DOI: 10.1067/mhj.2001.113998.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyMinimal lumen diameterLong-term clinical resultsFocal ISRStent groupClinical resultsStent restenosisLarger reference vessel diameterLesion lengthLesion revascularization rateTarget lesion revascularizationReference vessel diameterResidual diameter stenosisTransluminal coronary angioplastyLong-term resultsQ-wave infarctionPTCA groupUrgent revascularizationAngiographic successLesion revascularizationRevascularization ratesAdditional stentingBaseline characteristicsCoronary angioplastyDiabetic patientsEffectiveness of excimer laser coronary angioplasty in acute myocardial infarction or in unstable angina pectoris
Topaz O, Bernardo N, Shah R, McQueen R, Desai P, Janin Y, Lansky A, Carr M. Effectiveness of excimer laser coronary angioplasty in acute myocardial infarction or in unstable angina pectoris. The American Journal Of Cardiology 2001, 87: 849-855. PMID: 11274939, DOI: 10.1016/s0002-9149(00)01525-3.Peer-Reviewed Original ResearchConceptsExcimer laser coronary angioplastyUnstable angina pectorisAcute myocardial infarctionPercutaneous excimer laser coronary angioplastyAcute coronary syndromeUAP groupLaser coronary angioplastyAMI groupLaser successCoronary syndromeAngina pectorisCoronary angioplastyProcedural successMyocardial infarctionGlycoprotein IIb/IIIa receptor antagonistsIIb/IIIa receptor antagonistsAdjunct balloon dilationMyocardial infarction (TIMI) flowEmergency bypass surgeryIndependent core laboratoryMinimal luminal diameterCreatine kinase levelsFinal stenosisBurden areasBypass surgeryLocalized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
Leon M, Teirstein P, Moses J, Tripuraneni P, Lansky A, Jani S, Wong S, Fish D, Ellis S, Holmes D, Kerieakes D, Kuntz R. Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting. New England Journal Of Medicine 2001, 344: 250-256. PMID: 11172151, DOI: 10.1056/nejm200101253440402.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryBrachytherapyCombined Modality TherapyCoronary DiseaseCoronary ThrombosisDose-Response Relationship, RadiationDouble-Blind MethodFemaleGamma RaysHumansIridium RadioisotopesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsRadiotherapy DosageSecondary PreventionStentsConceptsIridium-192 groupMyocardial infarctionLate thrombosisStent restenosisIridium-192Intracoronary irradiationTarget lesionsIntracoronary gamma radiation therapyMajor adverse cardiac eventsFrequency of restenosisOral antiplatelet therapyAdverse cardiac eventsComposite of deathPrimary end pointLate myocardial infarctionIntracoronary radiation therapyIncidence of deathRecurrence of restenosisGamma radiation therapyEligible patientsAngiographic restenosisAntiplatelet therapyPlacebo groupCardiac eventsCoronary angioplastyClinical and angiographic outcome in the laser angioplasty for restenotic stents (LARS) multicenter registry
Giri S, Ito S, Lansky A, Mehran R, Margolis J, Gilmore P, Garratt K, Cummins F, Moses J, Rentrop P, Oesterle S, Power J, Kent K, Satler L, Pichard A, Wu H, Greenberg A, Bucher T, Kerker W, Abizaid A, Saucedo J, Leon M, Popma J. Clinical and angiographic outcome in the laser angioplasty for restenotic stents (LARS) multicenter registry. Catheterization And Cardiovascular Interventions 2001, 52: 24-34. PMID: 11146517, DOI: 10.1002/1522-726x(200101)52:1<24::aid-ccd1007>3.0.co;2-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAngioplasty, LaserChi-Square DistributionCoronary AngiographyCoronary DiseaseFemaleFollow-Up StudiesGraft Occlusion, VascularHumansMaleMiddle AgedMulticenter Studies as TopicProbabilityRandomized Controlled Trials as TopicRecurrenceRegistriesStentsSurvival RateTreatment OutcomeConceptsMulticenter case-control studyCase-control studyAngiographic recurrence rateUnstable anginaCoronary angioplastyAntegrade flowClinical outcomesProcedural successBalloon angioplastyRecurrence rateLate outcomesStent restenosisControl studyPatientsConsecutive proceduresNeointimal tissuePTCASuch treatmentAngioplastySimilar ratesOutcomesAnginaRestenosisLesionsISR
2000
Acute and long-term results of treatment of diffuse in-stent restenosis in aortocoronary saphenous vein grafts
Dangas G, Mehran R, Lansky A, Waksman R, Satler L, Pichard A, Kent K, Mintz G, Stone G, Leon M. Acute and long-term results of treatment of diffuse in-stent restenosis in aortocoronary saphenous vein grafts. The American Journal Of Cardiology 2000, 86: 777-779. PMID: 11018200, DOI: 10.1016/s0002-9149(00)01080-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplasty, Balloon, CoronaryAngioplasty, Balloon, Laser-AssistedCombined Modality TherapyCoronary Artery BypassCoronary Artery DiseaseFemaleGraft Occlusion, VascularHumansHyperplasiaMaleRecurrenceRisk FactorsSaphenous VeinStentsTreatment OutcomeUltrasonography, InterventionalConceptsSaphenous vein graftsVein graftsStent restenosisAortocoronary saphenous vein graftsHigher long-term mortalityExcimer laser coronary angioplastyAdjunct balloon angioplastyLong-term mortalityLaser coronary angioplastyTreatment of diffuseLong-term resultsRepeat revascularizationCoronary angioplastyAcute resultsBalloon angioplastyFrequent needAngioplastyRestenosisGraftTreatmentRevascularizationMortalityPrognostic value of cardiac troponin-I levels following catheter-based coronary interventions
Fuchs S, Kornowski R, Mehran R, Lansky A, Satler L, Pichard A, Kent K, Clark C, Stone G, Leon M. Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions. The American Journal Of Cardiology 2000, 85: 1077-1082. PMID: 10781755, DOI: 10.1016/s0002-9149(00)00699-8.Peer-Reviewed Original ResearchConceptsCatheter-based coronary interventionsCK-MB levelsHospital complicationsCoronary interventionCreatine kinase-MB fraction levelsCardiac event-free survivalIntermediate-term clinical outcomesTn-I levelsEvent-free survivalIntermediate-term outcomesRisk of mortalityQ-wave infarctionLesion revascularizationConsecutive patientsCoronary angioplastyIndependent predictorsClinical outcomesPrognostic significancePrognostic valueCoronary arteryMyocardial infarctionPlasma levelsSaphenous veinNormal limitsGroup IIIntracoronary β-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis
Waksman R, Bhargava B, White L, Chan R, Mehran R, Lansky A, Mintz G, Satler L, Pichard A, Leon M, Kent K. Intracoronary β-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis. Circulation 2000, 101: 1895-1898. PMID: 10779453, DOI: 10.1161/01.cir.101.16.1895.Peer-Reviewed Original ResearchConceptsRevascularization ratesBinary angiographic restenosis rateIntracoronary gamma radiation therapyTarget vessel revascularization rateTarget lesion revascularization ratePercutaneous transluminal coronary angioplastyVessel revascularization rateAngiographic restenosis rateLesion revascularization rateTransluminal coronary angioplastyIn-Stent RestenosisGamma radiation therapyRecurrent ISRPlacebo groupClinical restenosisAdjunct therapyConsecutive patientsCoronary angioplastyRestenosis rateRotational atherectomyStent implantationBalloon catheterNative coronariesStent restenosisPatientsVascular remodeling and the local delivery of cytochalasin B after coronary angioplasty in humans
Lehmann K, Popma J, Werner J, Lansky A, Wilensky R. Vascular remodeling and the local delivery of cytochalasin B after coronary angioplasty in humans. Journal Of The American College Of Cardiology 2000, 35: 583-591. PMID: 10716458, DOI: 10.1016/s0735-1097(99)00603-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCatheterization, PeripheralCoronary AngiographyCoronary DiseaseCoronary VesselsCytochalasin BDrug Delivery SystemsElectrocardiographyFeasibility StudiesFemaleHumansInfusions, Intra-ArterialMaleMiddle AgedMyocardial RevascularizationSafetyTreatment OutcomeConceptsCoronary angioplastyLocal deliveryVascular remodelingMinimal stenosis diameterSuccessful balloon angioplastyCombined end pointActive drug groupSuccessful coronary angioplastyLate lumen lossCytochalasin BSystemic drug administrationWarrants further studyInadequate dosingPlacebo groupClinical restenosisPharmacologic preventionAngioplasty siteClinical outcomesBalloon angioplastyLumen lossDrug groupsArterial constrictionElectrocardiographic variablesStenosis diameterAtherosclerotic plaquesComparison of time course of target lesion revascularization following successful saphenous vein graft angioplasty versus successful native coronary angioplasty
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Comparison of time course of target lesion revascularization following successful saphenous vein graft angioplasty versus successful native coronary angioplasty. The American Journal Of Cardiology 2000, 85: 256-258. PMID: 10955387, DOI: 10.1016/s0002-9149(99)00634-7.Peer-Reviewed Original Research
1999
Coronary Angioplasty with or without Stent Implantation for Acute Myocardial Infarction
Grines C, Cox D, Stone G, Garcia E, Mattos L, Giambartolomei A, Brodie B, Madonna O, Eijgelshoven M, Lansky A, O'Neill W, Morice M. Coronary Angioplasty with or without Stent Implantation for Acute Myocardial Infarction. New England Journal Of Medicine 1999, 341: 1949-1956. PMID: 10607811, DOI: 10.1056/nejm199912233412601.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTarget vessel revascularizationAngioplasty groupStent groupMyocardial infarctionPrimary angioplastyCoronary angioplastyStent implantationMean minimal luminal diameterSix-month mortality rateEnd pointCombined end pointPrimary end pointPrimary coronary angioplastyCoronary stent implantationMinimal luminal diameterRoutine implantationClinical benefitMulticenter studyEmergency catheterizationLower incidenceLuminal diameterAngioplastyBlood flowMortality rateLong-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings
Abizaid A, Mintz G, Mehran R, Abizaid A, Lansky A, Pichard A, Satler L, Wu H, Pappas C, Kent K, Leon M. Long-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings. Circulation 1999, 100: 256-261. PMID: 10411849, DOI: 10.1161/01.cir.100.3.256.Peer-Reviewed Original ResearchConceptsMinimum lumen areaIntravascular ultrasound findingsOnly independent predictorLumen areaIVUS minimum lumen areaEvent ratesDiabetes mellitusIndependent predictorsUltrasound findingsIVUS parametersArea stenosisLumen diameterPercutaneous transluminal coronary angioplastyLesion lumen areaNative artery lesionsTarget lesion revascularizationTransluminal coronary angioplastyCoronary artery stenosisMinimum lumen diameterLow event ratesArtery lesionsCardiac deathCoronary angioplastyArtery stenosisPlaque burden