Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults
van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC. Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults. The Journal Of Infectious Diseases 2007, 195: 1590-1597. PMID: 17471428, DOI: 10.1086/516788.Peer-Reviewed Original ResearchConceptsInfluenza vaccine responsesYears of ageCD86 expressionPostvaccine titersVaccine responsesMean numberCD80/CD86 expressionCostimulatory B7 moleculesCostimulatory molecules CD80Toll-like receptorsAntiviral prophylaxisInfluenza vaccineVaccine antibodiesVaccine immunityB7 moleculesAlternative vaccinesActivated monocytesHemagglutination inhibitionDecile increaseInnate immunityMean increaseVaccine strainCD80Flow cytometryTiter increase