1988
Allelic exclusion in transgenic mice carrying mutant human IgM genes.
Nussenzweig MC, Shaw AC, Sinn E, Campos-Torres J, Leder P. Allelic exclusion in transgenic mice carrying mutant human IgM genes. Journal Of Experimental Medicine 1988, 167: 1969-1974. PMID: 3133444, PMCID: PMC2189689, DOI: 10.1084/jem.167.6.1969.Peer-Reviewed Original ResearchConceptsAllelic exclusionHeavy chain geneChain geneMu chainsHuman mu chainsPrimary B cellsHybrid animalsIg heavy chain genesHuman heavy chainsMu expressionTransgenic mice resultsIgM geneGenesSimultaneous expressionSecreted versionTransgeneIg transgenesHeavy chainMice resultsTransgenic miceExpressionHuman Ig transgenesB cellsCellsVivo
1987
Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ
Nussenzweig M, Shaw A, Sinn E, Danner D, Holmes K, Morse H, Leder P. Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ. Science 1987, 236: 816-819. PMID: 3107126, DOI: 10.1126/science.3107126.Peer-Reviewed Original ResearchConceptsMembrane-bound formAllelic exclusionMembrane-bound proteinsMu chainsMu chain geneHeavy chainHeavy chain allelesHuman genesTransgenic miceImmunoglobulin μMessenger RNAMembrane formChain geneAntibody genesB cellsGenesImmunoglobulin M heavy chainHuman mu chainsMouse systemCellsRegulationMolecular formsRNATransgeneProtein