Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β
Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5063-5068. PMID: 18367668, PMCID: PMC2278186, DOI: 10.1073/pnas.0801235105.Peer-Reviewed Original ResearchConceptsMurine embryonic fibroblastsDNA damageDependent substrate phosphorylationDNA double-strand breaksType IA topoisomerasesCell cycle checkpointsDNA-damaging agentsS cell cycle checkpointDouble-strand breaksRegulation of totalSubstrate phosphorylationGenomic stabilityDsDNA breaksDNA replicationCycle checkpointsHomologous recombinationDNA repairUnanticipated roleEmbryonic fibroblastsAtaxia telangiectasiaCellular responsesTopoisomerase 3βPhosphorylationRad3Important role