2023
What are the benefits and drawbacks of statins in carotid artery disease? A perspective review
Said S, Dardik A, Chaar C. What are the benefits and drawbacks of statins in carotid artery disease? A perspective review. Expert Review Of Cardiovascular Therapy 2023, 21: 763-777. PMID: 37994875, PMCID: PMC11493559, DOI: 10.1080/14779072.2023.2286011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCarotid artery diseaseCarotid artery stenosisSide effectsArtery diseaseArtery stenosisAlternative therapiesSymptomatic carotid artery stenosisAtherosclerotic carotid artery diseaseMultiple international guidelinesAcute ischemic strokeImpact of statinsGenetic polymorphismsStatin side effectsWarrants close monitoringDrug of choiceSerious side effectsMechanism of statinStatin therapyCarotid revascularizationIschemic strokePCSK9 inhibitorsLipid controlStroke incidencePatient selectionClinical efficacyThe Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm
Nishibe T, Kano M, Akiyama S, Koizumi J, Dardik A. The Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm. Vascular And Endovascular Surgery 2023, 58: 178-184. PMID: 37789604, DOI: 10.1177/15385744231204238.Peer-Reviewed Original ResearchConceptsEndovascular aortic repairAbdominal aortic aneurysmLower preoperative LMROverall mortalityPreoperative LMRMonocyte ratioAortic repairIndependent predictorsAortic aneurysmChronic obstructive pulmonary diseaseTokyo Medical University HospitalAbsolute lymphocyte countObstructive pulmonary diseaseAbsolute monocyte countMedical University HospitalPotential surrogate biomarkerPoor nutritional statusCharacteristic curve analysisPreoperative lymphocyteActive cancerMedian followLymphocyte countMultivariable analysisPulmonary diseasePoor prognosisEnhancing the vascular surgeon-scientist workforce with diversity and team science
Nguyen M, Dardik A. Enhancing the vascular surgeon-scientist workforce with diversity and team science. Journal Of Vascular Surgery 2023, 78: 852-853. PMID: 37739745, DOI: 10.1016/j.jvs.2023.06.005.Commentaries, Editorials and LettersRates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020
Nguyen M, Gonzalez L, Newman A, Cannon A, Zarebski S, Chaudhry S, Pomahac B, Boatright D, Dardik A. Rates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020. JAMA Surgery 2023, 158: 756-764. PMID: 37195709, PMCID: PMC10193263, DOI: 10.1001/jamasurg.2023.1571.Peer-Reviewed Original ResearchConceptsHealth fundingNational InstituteNIH fundingCross-sectional studyDepartment of SurgeryGlobal disease burdenNumber of NIHNIH RePORTER databaseDisease burdenSurgical diseaseSurgical departmentPatient careResearch project grantsClinical settingSurgical subspecialtiesPhD scientistsSurgeryNIH grantsSubstantial disparitiesBoard certificationNIH investigatorsNIHClinical demandInvestigatorsProject grantsTransition From Mentored to Independent NIH Funding by Gender and Department
Nguyen M, Panyadahundi A, Olagun-Samuel C, Chaudhry S, Desai M, Dardik A, Boatright D. Transition From Mentored to Independent NIH Funding by Gender and Department. JAMA 2023, 329: 2189-2190. PMID: 37367985, PMCID: PMC10300699, DOI: 10.1001/jama.2023.7693.Peer-Reviewed Original ResearchComputer Science meets Vascular Surgery: Keeping a pulse on artificial intelligence
Thaxton C, Dardik A. Computer Science meets Vascular Surgery: Keeping a pulse on artificial intelligence. Seminars In Vascular Surgery 2023, 36: 419-425. PMID: 37863614, PMCID: PMC10589450, DOI: 10.1053/j.semvascsurg.2023.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsArtificial intelligenceComputer scienceVascular surgeryHealth dataAIIntelligenceHealth care disparitiesHealth care systemRisk stratificationVascular careCare disparitiesProvider experienceTechnologyCare systemHealth care fieldWay careClinical applicationSurgeryNovel technologyApplicationsCareUnique ethical considerationsBroader integrationCare fieldRange of disciplinesSex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creationAssociation of simple renal cysts to aneurysm sac shrinkage in true thoracic aortic aneurysms after thoracic endovascular aortic repair
Kano M, Nishibe T, Iwahashi T, Maekawa K, Nakano Y, Matsumoto R, Fujiyoshi T, Ogino H, Kato N, Dardik A. Association of simple renal cysts to aneurysm sac shrinkage in true thoracic aortic aneurysms after thoracic endovascular aortic repair. Journal Of Vascular Surgery 2023, 78: 624-632. PMID: 37116594, DOI: 10.1016/j.jvs.2023.02.031.Peer-Reviewed Original ResearchConceptsAneurysm sac shrinkageTrue thoracic aortic aneurysmSimple renal cystsThoracic aortic aneurysmSac shrinkageAneurysm sac sizeEndovascular aortic repairAortic repairAortic aneurysmRenal cystsPresence of SRCSac sizePostoperative computed tomography scansPreoperative computed tomographyComputed tomography scanMultivariable analysisTrue aneurysmUniversity HospitalThoracic aortaSac diameterTomography scanComputed tomographyTEVARPatientsAortic wallThe management of patients with popliteal artery aneurysms presenting with acute limb ischemia
Satam K, Aboian E, Cardella J, Slade M, Nassiri N, Dardik A, Guzman R, Ochoa Chaar C. The management of patients with popliteal artery aneurysms presenting with acute limb ischemia. Journal Of Vascular Surgery 2023, 78: 506-513. PMID: 37086824, DOI: 10.1016/j.jvs.2023.04.019.Peer-Reviewed Original ResearchConceptsAcute limb ischemiaEndovascular repairPeripheral vascular interventionsOpen repairLimb ischemiaEndovascular popliteal artery aneurysm repairPopliteal artery aneurysm repairVascular Quality Initiative databaseMajor amputation ratePopliteal artery aneurysmsCoronary artery diseaseManagement of patientsLong-term outcomesMultivariable regression analysisHigher inpatientMajor amputationPAA repairAmputation rateHospital lengthPerioperative complicationsPerioperative mortalityPostoperative lengthDecreased complicationsInfrainguinal bypassOnly patientsSignificance of perioperative intrasac pressure in sac shrinkage after endovascular abdominal aneurysm repair.
Kano M, Nishibe T, Matsumoto R, Fujiyoshi T, Toya N, Dardik A, Ogino H. Significance of perioperative intrasac pressure in sac shrinkage after endovascular abdominal aneurysm repair. International Angiology 2023, 42: 201-208. PMID: 37067390, DOI: 10.23736/s0392-9590.23.05004-6.Peer-Reviewed Original ResearchConceptsAneurysm sac shrinkageEndovascular aneurysm repairIndependent risk factorSac shrinkageSystolic pressure indexIntrasac pressurePressure indexAneurysm repairRisk factorsEndovascular abdominal aneurysm repairGore C3 ExcluderSystemic blood pressureAbdominal aneurysm repairStent-graft deploymentC3 ExcluderBlood pressureMultivariable analysisUniversity HospitalGraft deploymentPatientsStent deploymentAneurysm sacOne-yearMarked reductionLikely causeInfluence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease
Nishibe T, Kano M, Akiyama S, Chiba F, Nishibe M, Koizumi J, Dardik A. Influence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease. Annals Of Vascular Surgery 2023, 94: 136-142. PMID: 37019357, DOI: 10.1016/j.avsg.2023.03.031.Peer-Reviewed Original ResearchConceptsAnkle-brachial pressure indexSkeletal muscle mass indexPeripheral artery diseaseSkeletal muscle massBioelectrical impedance analysisMuscle massLimb ischemiaArtery diseaseLow ankle-brachial pressure indexSkeletal muscle mass depletionSymptomatic peripheral artery diseaseTokyo Medical University HospitalMuscle mass depletionBrachial pressure indexLower limb ischemiaMuscle mass indexMedical University HospitalNonischemic legsExercise therapyIntermittent claudicationIschemic legDuplex scanEndovascular treatmentMass indexPhysical functionRacial disparities in vascular care need attention without delay
Paraskevas K, Dardik A, Gloviczki P. Racial disparities in vascular care need attention without delay. Journal Of Vascular Surgery 2023, 77: 1289-1291. PMID: 36948682, DOI: 10.1016/j.jvs.2022.12.028.Commentaries, Editorials and LettersCarbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease
Lee S, Ali S, Cardella J, Turner J, Guzman R, Dardik A, Ochoa Chaar C. Carbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease. Journal Of Vascular Surgery 2023, 78: 201-208. PMID: 36948278, DOI: 10.1016/j.jvs.2023.03.029.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseasePeripheral vascular interventionsContrast volume usagePC-AKICarbon dioxide angiographyCardiac complicationsPropensity matchingKidney diseaseVascular interventionsPost-contrast acute kidney injuryAcute kidney injuryOutcomes of patientsPeripheral arterial diseasePoor renal functionMultivariate logistic regressionLower contrast volumeVolume of contrastCardiac comorbiditiesKidney injuryMinor amputationRenal complicationsRenal functionEndovascular therapyArterial diseaseSafety and efficacy of thoracic endovascular aortic repair for acute Stanford type B aortic dissection with retrograde type A intramural hematoma
Wang J, Li M, Li J, He H, Zhou Y, Li X, Li Q, Gu F, Ye Z, Dardik A, Shu C. Safety and efficacy of thoracic endovascular aortic repair for acute Stanford type B aortic dissection with retrograde type A intramural hematoma. Journal Of Vascular Surgery 2023, 78: 61-69.e4. PMID: 36921645, DOI: 10.1016/j.jvs.2023.02.021.Peer-Reviewed Original ResearchConceptsThoracic endovascular aortic repairType B aortic dissectionAcute Stanford type B aortic dissectionStanford type B aortic dissectionB aortic dissectionEndovascular aortic repairHematoma thicknessAortic dissectionRetrograde typeIntramural hematomaAortic repairMaximal diameterAcute type B aortic dissectionOverall cumulative survival rateCumulative survival rateCumulative freedomAortic remodelingComplication rateEndovascular repairMedian intervalPatient characteristicsSymptom onsetAortic diameterAlternative treatmentPatientsGender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020
Nguyen M, Gonzalez L, Chaudhry S, Ahuja N, Pomahac B, Newman A, Cannon A, Zarebski S, Dardik A, Boatright D. Gender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020. JAMA Network Open 2023, 6: e233630. PMID: 36939702, PMCID: PMC10028489, DOI: 10.1001/jamanetworkopen.2023.3630.Peer-Reviewed Original ResearchConceptsCross-sectional studyNIH fundingNational InstitutePatient-centered researchNIH RePORTER databaseWarrants further investigationPrincipal investigatorSurgical diseaseGlobal burdenMAIN OUTCOMEResearch project grantsSurgeonsWomenHealth fundingAcademic surgeonsMenNIH grantsDiseaseFurther investigationArterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentageAccuracy of the pedal acceleration time to diagnose limb ischemia in patients with and without diabetes using the WIfI classification
de Castro-Santos G, Gonçalves P, Procópio R, Dardik A, Navarro T. Accuracy of the pedal acceleration time to diagnose limb ischemia in patients with and without diabetes using the WIfI classification. Vascular Medicine 2023, 28: 36-44. PMID: 36759936, DOI: 10.1177/1358863x221150453.Peer-Reviewed Original ResearchConceptsAnkle-brachial indexChronic limb-threatening ischemiaGrade of ischemiaAmputation riskWIfI stageFoot Infection (WIfI) scoreHigher amputation riskLimb-threatening ischemiaLower limb ischemiaReceiver operator characteristic curveCross-sectional studyOperator characteristic curveWIfI classificationLimb ischemiaLimb hemodynamicsInclusion criteriaInfection scoreSkin lesionsAcceleration timeExtensive necrosisIschemiaPatientsDiabetesLower limbsCharacteristic curveClarifying the rationale supporting selective screening for asymptomatic carotid artery stenosis
Paraskevas K, Nicolaides A, Spence J, Mikhailidis D, Lanza G, Liapis C, Goudot G, Faggioli G, Pini R, Musiałek P, Suri J, Silvestrini M, Fernandes E Fernandes J, Eckstein H, Jawien A, Spinelli F, Stilo F, Myrcha P, Rundek T, Kakkos S, Di Lazzaro V, Svetlikov A, Antignani P, Poredos P, Saba L, Jezovnik M, Blinc A, Sultan S, Knoflach M, Jezovnik M, Capoccia L, Proczka R, Fraedrich G, Zeebregts C, Davies A, Geroulakos G, Ricco J, Mansilha A, Dardik A, Gloviczki P. Clarifying the rationale supporting selective screening for asymptomatic carotid artery stenosis. International Journal Of Cardiology 2023, 376: 174-175. PMID: 36681248, DOI: 10.1016/j.ijcard.2023.01.028.Peer-Reviewed Original ResearchSafety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data
Leung Y, Bera K, Rodriguez D, Dardik A, Mas J, Simonte G, Rerkasem K, Howard D. Safety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data. Stroke 2023, 54: 457-467. PMID: 36647921, PMCID: PMC9855737, DOI: 10.1161/strokeaha.122.040819.Peer-Reviewed Original ResearchConceptsIndividual patient dataSymptomatic elderly patientsSymptomatic carotid stenosisCarotid endarterectomyPerioperative strokeElderly patientsStroke riskMedical therapyCarotid stenosisMyocardial infarctionPatient dataStroke risk increasesRecurrent stroke riskSymptomatic stenosisInterventional armPerioperative deathsPerioperative riskAdverse eventsProspective cohortSymptomatic patientsRandomized trialsOutcome ratesObservational studyOctogenariansEndarterectomy
2022
Screening for asymptomatic carotid stenosis in patients with non-valvular atrial fibrillation
Paraskevas K, Eckstein H, Mansilha A, Ricco J, Geroulakos G, Di Lazzaro V, Rundek T, Lanza G, Fraedrich G, Svetlikov A, Suri J, Zeebregts C, Davies A, Capoccia L, Proczka R, Myrcha P, Antignani P, Fernandes E Fernandes J, Spence J, Dardik A, Jezovnik M, Knoflach M, Lavenson G, Kakkos S, Jawien A, Silvestrini M, Blinc A, Spinelli F, Stilo F, Musiałek P, Sultan S, Goudot G, Liapis C, Saba L, Faggioli G, Pini R, Poredos P, Mikhailidis D, Gloviczki P, Nicolaides A. Screening for asymptomatic carotid stenosis in patients with non-valvular atrial fibrillation. International Journal Of Cardiology 2022, 372: 120-121. PMID: 36435330, DOI: 10.1016/j.ijcard.2022.11.037.Peer-Reviewed Original Research