2010
Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques.
Muto A, Nishibe T, Miyauchi Y, Kondo Y, Yamamoto Y, Dardik A, Shigematsu H. Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques. International Angiology 2010, 29: 43-8. PMID: 20357748.Peer-Reviewed Original ResearchConceptsArteriosclerosis obliteransAtherosclerotic femoral arteriesPharmacological treatmentFemoral arteryReceptor EP2IP receptorAtherosclerotic plaquesMedial layerAtherosclerotic arteriesWestern blottingSevere arteriosclerosis obliteransFemoropopliteal bypass surgeryCOX-2 expressionProstaglandin receptor agonistsProstaglandin receptor EP2Pharmacological managementBypass surgeryReceptor agonistArterial intimaIntimal layerPG receptorsArteryPlatelet aggregationPatientsEP2
1999
Chronic in vitro shear stress stimulates endothelial cell retention on prosthetic vascular grafts and reduces subsequent in vivo neointimal thickness
Dardik A, Liu A, Ballermann B. Chronic in vitro shear stress stimulates endothelial cell retention on prosthetic vascular grafts and reduces subsequent in vivo neointimal thickness. Journal Of Vascular Surgery 1999, 29: 157-167. PMID: 9882800, DOI: 10.1016/s0741-5214(99)70357-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsBeta-GalactosidaseBlood Vessel ProsthesisCell AdhesionCells, CulturedEndothelium, VascularFemaleGenetic VectorsHemorheologyHemostasisIn Vitro TechniquesMicroscopy, Electron, ScanningPolyurethanesRatsRats, Inbred F344Stress, MechanicalThrombosisTransfectionTunica IntimaConceptsProsthetic vascular graftsNeointimal thicknessDyne/cm2 shear stressEndothelial cellsGraft thrombosisEndothelial cell monolayersEndothelial cell retentionHemostasis timeVascular graftsCell monolayersAlpha-smooth muscle actinFischer 344 rat aortaGraft patency rateReplication-deficient adenoviral vectorLuminal surfaceAortic interposition graftsImmediate graft thrombosisChronic shear stressCultured endothelial cellsGraft failureInterposition graftMacrophage infiltrationPatency ratesCell-seeded graftsRat aorta