2024
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024 PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysis
2022
Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Wadhwa R, Fava A, Lever HM, Thamilarasan M, Popovic ZB, Smedira NG, Desai MY. Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy. Progress In Cardiovascular Diseases 2022, 74: 11-18. PMID: 35952727, DOI: 10.1016/j.pcad.2022.08.002.Peer-Reviewed Original ResearchConceptsSeptal reduction therapyBNP ratioNT-proBNP ratioPrimary outcomeAsymptomatic patientsPrognostic valueObstructive hypertrophic cardiomyopathy patientsIncremental prognostic valueNormal NT-proBNPNT-pro BNPObstructive hypertrophic cardiomyopathyLong-term outcomesHypertrophic cardiomyopathy patientsCardiac transplantationNT-proBNPPrimary endpointCardiomyopathy patientsHypertrophic cardiomyopathyReduction therapyHigh riskPatientsDefibrillator dischargeSpline analysisOutcomesBNP
2021
Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy
Alashi A, Smedira NG, Popovic ZB, Fava A, Thamilarasan M, Kapadia SR, Wierup P, Lever HM, Desai MY. Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy. Journal Of The American Heart Association 2021, 10: e018527. PMID: 33506683, PMCID: PMC7955450, DOI: 10.1161/jaha.120.018527.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tract gradientVentricular outflow tract gradientOutflow tract gradientElderly patientsHypertrophic cardiomyopathyTract gradientObstructive subgroupRisk factorsDynamic left ventricular outflow tract obstructionSudden cardiac death risk factorsLeft ventricular outflow tract obstructionAppropriate internal defibrillator dischargeVentricular outflow tract obstructionBasal septal thicknessConclusion Elderly patientsDeath risk factorsSeptal reduction therapyThoracic Surgeons scoreConsecutive elderly patientsOutflow tract obstructionVentricular mass indexBasal septal hypertrophyLong-term outcomesHospital deathTract obstruction
2020
Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy
Alashi A, Smedira NG, Hodges K, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Desai MY. Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy. Journal Of The American Heart Association 2020, 10: e016210. PMID: 33342243, PMCID: PMC7955478, DOI: 10.1161/jaha.120.016210.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresCardiomyopathy, HypertrophicDissectionEarly Medical InterventionEchocardiography, StressExercise TestFemaleHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsVentricular outflow tract gradientObstructive coronary artery diseaseBetter long-term survivalSurgical myectomyOutflow tract gradientObstructive hypertrophic cardiomyopathyCoronary artery diseaseLong-term survivalClass ITract gradientEarly surgeryArtery diseaseHypertrophic cardiomyopathyLeft ventricular outflow tract gradientAppropriate internal defibrillator dischargePrimary composite end pointBasal septal thicknessClass I indicationsPrimary composite eventsHypertrophic obstructive cardiomyopathyComposite end pointLong-term outcomesComposite eventsEarly referralObstructive cardiomyopathyCharacteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function
Alashi A, Isaza N, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function. Journal Of The American Heart Association 2020, 9: e016537. PMID: 32755253, PMCID: PMC7660826, DOI: 10.1161/jaha.120.016537.Peer-Reviewed Original ResearchConceptsBaseline LV ejection fractionLV ejection fractionIncremental prognostic valueLV-GLSTakotsubo syndromePrognostic valueLower baseline LV ejection fractionObstructive coronary artery diseaseVentricular global longitudinal strainMultivariate Cox survival analysisMean LV ejection fractionWorse LV-GLSOutcomes of patientsPrimary end pointVentricular systolic functionCoronary artery diseaseGlobal longitudinal strainLong-term outcomesCox survival analysisPhysical triggersPrognostic cutoffCause mortalityApical ballooningConclusions PatientsSystolic functionExaggerated blood pressure response on exercise treadmill testing and longer term outcomes in primary prevention
Riaz H, Alashi A, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Cremer P, Jaber W, Griffin BP, Desai MY. Exaggerated blood pressure response on exercise treadmill testing and longer term outcomes in primary prevention. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 6: 343-344. PMID: 32514546, DOI: 10.1093/ehjqcco/qcaa043.Peer-Reviewed Original ResearchLONG-TERM OUTCOMES AMONG PATIENTS WITH MEDIASTINAL RADIATION-INDUCED CORONARY ARTERY DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION VERSUS CORONARY ARTERY BYPASS GRAFTING
Dunn A, Donnellan E, Alashi A, Johnston D, Jellis C, Pettersson G, Svensson L, Reed G, Ellis S, Griffin B, Desai M. LONG-TERM OUTCOMES AMONG PATIENTS WITH MEDIASTINAL RADIATION-INDUCED CORONARY ARTERY DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION VERSUS CORONARY ARTERY BYPASS GRAFTING. Journal Of The American College Of Cardiology 2020, 75: 1150. DOI: 10.1016/s0735-1097(20)31777-0.Peer-Reviewed Original Research
2019
226Earlier surgical myectomy vs. waiting for a Class I indication is associated with improved long-term survival in symptomatic hypertrophic obstructive cardiomyopathy patients
Alashi A, Smedira N, Hodges K, Popovic Z, Thamilarasan M, Wierup P, Lever H, Desai M. 226Earlier surgical myectomy vs. waiting for a Class I indication is associated with improved long-term survival in symptomatic hypertrophic obstructive cardiomyopathy patients. European Heart Journal 2019, 40: ehz747.0061. DOI: 10.1093/eurheartj/ehz747.0061.Peer-Reviewed Original ResearchClass I indicationsHypertrophic obstructive cardiomyopathySevere hypertrophic obstructive cardiomyopathySurgical myectomyHOCM patientsComposite endpointMedical therapySymptomatic hypertrophic obstructive cardiomyopathy patientsAppropriate internal defibrillator dischargeHypertrophic obstructive cardiomyopathy patientsVentricular outflow tract gradientImproved long-term survivalClass ILong-term event ratesBasal septal thicknessMaximal medical therapyOutflow tract gradientLong-term outcomesDeath risk scoreRisk survival analysisLong-term survivalExercise echoTract gradientExercise toleranceObstructive cardiomyopathyCHARACTERISTICS AND LONGER-TERM OUTCOMES OF PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE
Alashi A, Svensson L, Klein J, Zahka K, Smedira N, Najm H, Stewart R, Lever H, Aziz P, Saarel E, Desai M. CHARACTERISTICS AND LONGER-TERM OUTCOMES OF PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE. Journal Of The American College Of Cardiology 2019, 73: 878. DOI: 10.1016/s0735-1097(19)31485-8.Peer-Reviewed Original Research
2018
Characteristics and longer-term outcomes of paravalvular leak after aortic and mitral valve surgery
Shah S, Alashi A, Pettersson GB, Rodriguez LL, Gillinov AM, Grimm RA, Navia J, Kapadia SR, Svensson LG, Griffin BP, Desai MY. Characteristics and longer-term outcomes of paravalvular leak after aortic and mitral valve surgery. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 1785-1792.e1. PMID: 30414770, DOI: 10.1016/j.jtcvs.2018.08.096.Peer-Reviewed Original ResearchConceptsReoperative cardiac surgeryLong-term mortalityRight ventricular systolic pressureGreater paravalvular leakMitral valve surgeryVentricular systolic pressureParavalvular leakLong-term outcomesLong-term survivalSTS scoreMV surgeryValve surgeryInfectious etiologySystolic pressureMultivariable Cox survival analysisGreater long-term mortalityAortic paravalvular leakMean STS scoreThoracic Surgeons scoreMild paravalvular leakVentricular ejection fractionCox survival analysisExcellent perioperative outcomesPerioperative outcomesPrimary endpointLONG TERM OUTCOMES AFTER AORTIC VALVE SURGERY IN PATIENTS WITH ASYMPTOMATIC CHRONIC AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION: ROLE OF PRE AND POST-OPERATIVE GLOBAL LONGITUDINAL STRAIN
Khullar T, Alashi A, Mentias A, Johnston D, Gillinov A, Rodriguez L, Svensson L, Popovic Z, Griffin B, Desai M. LONG TERM OUTCOMES AFTER AORTIC VALVE SURGERY IN PATIENTS WITH ASYMPTOMATIC CHRONIC AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION: ROLE OF PRE AND POST-OPERATIVE GLOBAL LONGITUDINAL STRAIN. Journal Of The American College Of Cardiology 2018, 71: a2014. DOI: 10.1016/s0735-1097(18)32555-5.Peer-Reviewed Original ResearchPRESERVED LEFT VENTRICULAR EJECTION FRACTIONAsymptomatic chronic aortic regurgitationLeft ventricular ejection fractionAortic valve surgeryChronic aortic regurgitationVentricular ejection fractionGlobal longitudinal strainLong-term outcomesValve surgeryAortic regurgitationEjection fractionTerm outcomesRole of preLongitudinal strainRegurgitationPatientsSurgery
2016
Long-Term Outcomes in Patients With Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
Mentias A, Feng K, Alashi A, Rodriguez LL, Gillinov AM, Johnston DR, Sabik JF, Svensson LG, Grimm RA, Griffin BP, Desai MY. Long-Term Outcomes in Patients With Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. Journal Of The American College Of Cardiology 2016, 68: 2144-2153. PMID: 27855803, DOI: 10.1016/j.jacc.2016.08.045.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionAV surgeryVentricular ejection fractionAortic regurgitationLong-term survivalEjection fractionSuch patientsLeft ventricleChronic severe aortic regurgitationSex-matched U.S. populationLV end-systolic dimensionMultivariate Cox survival analysisGreater aortic regurgitationHospital postoperative mortalityMean STS scoreThoracic Surgeons scoreAortic valve surgeryChronic aortic regurgitationSevere aortic regurgitationEnd-systolic dimensionSurvival of patientsLong-term outcomesRisk of deathCox survival analysisPostoperative mortality