Spermatozoa protein alterations in infertile men with bilateral varicocele
Agarwal A, Sharma R, Durairajanayagam D, Cui Z, Ayaz A, Gupta S, Willard B, Gopalan B, Sabanegh E. Spermatozoa protein alterations in infertile men with bilateral varicocele. Asian Journal Of Andrology 2015, 18: 43-53. PMID: 25999357, PMCID: PMC4736356, DOI: 10.4103/1008-682x.153848.Peer-Reviewed Original ResearchConceptsInfertile menBilateral varicoceleFertile menAssociated with metabolic processesSperm-zona bindingVaricocele casesFunctional proteomic profilingVaricocele-associated male infertilityImmune system processPresence of DEPSperm-zonaSperm functionFertile control groupCells of patientsFertile donorsEnzyme regulationIdentified proteinsOxidoreductase activityMale infertilitySpermatozoa cellsProteomic analysisWestern blot analysisStress responseMetabolic processesProteomic profilingDifferential Proteomic Profiling of Spermatozoal Proteins of Infertile Men With Unilateral or Bilateral Varicocele
Agarwal A, Sharma R, Durairajanayagam D, Cui Z, Ayaz A, Gupta S, Willard B, Gopalan B, Sabanegh E. Differential Proteomic Profiling of Spermatozoal Proteins of Infertile Men With Unilateral or Bilateral Varicocele. Urology 2015, 85: 580-588. PMID: 25733269, DOI: 10.1016/j.urology.2014.11.030.Peer-Reviewed Original ResearchConceptsSperm protein profilePost-translational modificationsInfertile menRoutine sperm parametersProtein profilesSodium dodecyl sulfate-polyacrylamide gel electrophoresisDodecyl sulfate-polyacrylamide gel electrophoresisSulfate-polyacrylamide gel electrophoresisFunctional proteomic profilingGel analysis softwareVaricocele-associated male infertilitySperm deoxyribonucleic acid fragmentationComparing spectral countsVaricocele samplesDeoxyribonucleic acid fragmentationProtein foldingSperm parametersDifferential proteomic profilingProtein ubiquitinationCellular functionsSignal transductionGel electrophoresisExpressed proteinsMale infertilityReactive oxygen species