2024
Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments
Armbruster‐Genç D, Neil L, Valton V, Phillips H, Rankin G, Sharp M, Rapley J, Viding E, Roiser J, McCrory E. Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments. Journal Of Child Psychology And Psychiatry 2024 PMID: 39665511, DOI: 10.1111/jcpp.14095.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingReward learningOrbitofrontal cortexChildhood maltreatmentProbabilistic reinforcement learning taskDocumented history of maltreatmentAtypical reward processingOrbitofrontal cortex connectivityNon-maltreated individualsLower exploratory behaviorMid-cingulate cortexDisrupt neural processingHistory of maltreatmentImpact of maltreatmentReinforcement learning taskPrefrontal activationReward processingReward contingenciesNeural indicesOutcome deliveryNeural signalsLatent vulnerabilityBehavioral measuresInternalising symptomsOutcome processing
2017
A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin M, Puetz V, Blair R, White S, Sethi A, Hoffmann F, Palmer A, Viding E, McCrory E. A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children. Development And Psychopathology 2017, 29: 1689-1705. PMID: 29162176, DOI: 10.1017/s095457941700133x.Peer-Reviewed Original ResearchConceptsMaltreated groupReinforcement-based decisionEarly adverse environmentsFunctional magnetic resonanceSuperior temporal gyrusMedial temporal structuresPassive avoidance taskMiddle cingulate gyrusNegative cuesReinforcement expectanciesMaltreated childrenPsychosocial functioningTemporal gyrusPrediction errorVulnerability mechanismsAvoidance taskNonmaltreated peersOrbitofrontal cortexLatent vulnerabilityChildhood abuseWidespread networkValue processingPsychiatric vulnerabilityValue representationCingulate gyrus
2016
The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification
Kelly P, Viding E, Puetz V, Palmer A, Samuel S, McCrory E. The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification. Journal Of Neural Transmission 2016, 123: 1069-1083. PMID: 26922372, PMCID: PMC5003912, DOI: 10.1007/s00702-016-1523-8.Peer-Reviewed Original ResearchConceptsCortical thicknessLocal gyrificationCortical structuresParietal cortexRight inferior parietal cortexRight anterior cingulateLeft precentral gyrusSuperior frontal gyrusInferior parietal cortexSuperior parietal cortexPrecentral gyrusBrain areasAnterior cingulateDimorphic impactMaltreatment experiencesOrbitofrontal cortexBrain structuresLarge community sampleMaltreatment exposureFrontal gyrusGyrificationCortexSex influenceAtypical patternsCommunity sample
2015
Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation
Kelly P, Viding E, Puetz V, Palmer A, Mechelli A, Pingault J, Samuel S, McCrory E. Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation. Development And Psychopathology 2015, 27: 1591-1609. PMID: 26535946, DOI: 10.1017/s0954579415000966.Peer-Reviewed Original ResearchConceptsGray matter volumeAttentional avoidanceEmotional functioningSupramarginal gyrusVisual dot-probe taskMatter volumeSex differencesDot-probe taskBilateral supramarginal gyrusLarge community sampleMedial orbitofrontal cortexOrbitofrontal cortex gray matter volumeAttentional biasMiddle temporal lobePeer functioningThreat processingSocioemotional functioningEmotional reactivityNeural basisMaltreated groupMaltreated childrenMultilevel investigationCommunity sampleNonmaltreated peersOrbitofrontal cortex
2013
Cortical Thickness, Surface Area, and Gyrification Abnormalities in Children Exposed to Maltreatment: Neural Markers of Vulnerability?
Kelly P, Viding E, Wallace G, Schaer M, De Brito S, Robustelli B, McCrory E. Cortical Thickness, Surface Area, and Gyrification Abnormalities in Children Exposed to Maltreatment: Neural Markers of Vulnerability? Biological Psychiatry 2013, 74: 845-852. PMID: 23954109, DOI: 10.1016/j.biopsych.2013.06.020.Peer-Reviewed Original ResearchConceptsCortical thicknessLingual gyrusAnterior cingulateLeft middle temporal areaSuperior frontal gyrusBrain volume differencesAtypical neural structureCortical surface areaMiddle temporal areaPrevious neuroimaging studiesGyrification abnormalitiesTemporal lobePsychiatric disordersLocal gyrificationPsychiatric riskHistory of abuseStructural abnormalitiesTemporal areaClinical disordersBiological markersOrbitofrontal cortexPrefrontal cortexBrain structuresGyrusNeuroimaging studies
2012
Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children
De Brito S, Viding E, Sebastian C, Kelly P, Mechelli A, Maris H, McCrory E. Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children. Journal Of Child Psychology And Psychiatry 2012, 54: 105-112. PMID: 22880630, DOI: 10.1111/j.1469-7610.2012.02597.x.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexPsychiatric disordersMiddle temporal gyrusOrbitofrontal cortexTemporal lobeGray matterTemporal gyrusConcurrent psychiatric disordersTemporal gray matterGray matter volumeVoxel-based morphometryCommunity sampleLeft middle temporal gyrusAtypical neural structurePrevious neuroimaging studiesNeurobiological risk factorsRisk factorsLevel of anxietyMatter volumePosttraumatic stress symptomsPsychiatric vulnerabilityConcurrent anxietyPrefrontal cortexCortexNeuroimaging studies