2024
Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments
Armbruster‐Genç D, Neil L, Valton V, Phillips H, Rankin G, Sharp M, Rapley J, Viding E, Roiser J, McCrory E. Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments. Journal Of Child Psychology And Psychiatry 2024 PMID: 39665511, DOI: 10.1111/jcpp.14095.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingReward learningOrbitofrontal cortexChildhood maltreatmentProbabilistic reinforcement learning taskDocumented history of maltreatmentAtypical reward processingOrbitofrontal cortex connectivityNon-maltreated individualsLower exploratory behaviorMid-cingulate cortexDisrupt neural processingHistory of maltreatmentImpact of maltreatmentReinforcement learning taskPrefrontal activationReward processingReward contingenciesNeural indicesOutcome deliveryNeural signalsLatent vulnerabilityBehavioral measuresInternalising symptomsOutcome processing
2022
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2019
Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment status
2015
Exploring the Relationship Between Childhood Maltreatment and Addiction: A Review of the Neurocognitive Evidence
Puetz V, McCrory E. Exploring the Relationship Between Childhood Maltreatment and Addiction: A Review of the Neurocognitive Evidence. Current Addiction Reports 2015, 2: 318-325. PMID: 26550550, PMCID: PMC4628081, DOI: 10.1007/s40429-015-0073-8.Peer-Reviewed Original ResearchSubstance use disordersChildhood maltreatmentSeverity of illnessSevere clinical presentationClinical presentationPsychiatric disordersUse disordersBrain structuresHistory of maltreatmentDisordersAdultsRiskExecutive functioningMaltreatmentAlterationsNeurocognitive systemsSalient stimuliLatent vulnerabilityIllnessRisk environmentImpairment