2001
Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives
Martı́nez-Botas J, Ferruelo A, Suárez Y, Fernández C, Gómez-Coronado D, Lasunción M. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. Biochimica Et Biophysica Acta 2001, 1532: 185-194. PMID: 11470239, DOI: 10.1016/s1388-1981(01)00125-1.Peer-Reviewed Original ResearchConceptsCell proliferationLow-density lipoprotein cholesterolCell cycle progressionDose-dependent effectCell cycle distributionCell cycleCycle progressionLipoprotein cholesterolConcentrations of lovastatinCholesterol supplyCycle distributionCholesterolLovastatinHuman cell linesCell linesCholesterol biosynthesisCholesterol-free mediumNormal cell cyclingM phaseProgressionProliferationPresent studyHL-60Mevalonate derivativesCell cycling
1999
Cholesterol starvation decreases P34cdc2 kinase activity and arrests the cell cycle at G2
Martínez‐Botas J, Suárez Y, Ferruelo A, Gómez‐Coronado D, Lasunció M. Cholesterol starvation decreases P34cdc2 kinase activity and arrests the cell cycle at G2. The FASEB Journal 1999, 13: 1359-1370. PMID: 10428760, DOI: 10.1096/fasebj.13.11.1359.Peer-Reviewed Original Research