2020
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
Benito-Vicente A, Uribe KB, Rotllan N, Ramírez CM, Jebari-Benslaiman S, Goedeke L, Canfrán-Duque A, Galicia-García U, De Urturi D, Aspichueta P, Suárez Y, Fernández-Hernando C, Martín C. miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression. International Journal Of Molecular Sciences 2020, 21: 8675. PMID: 33212990, PMCID: PMC7698485, DOI: 10.3390/ijms21228675.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin receptor substrate-1Type 2 diabetes mellitusHepatic insulin resistanceInsulin receptorInsulin receptor expressionImplication of microRNAsDiabetes mellitusHeart failureCardiometabolic pathologiesInsulin sensitivityReceptor expressionINSR expressionReceptor substrate-1Human hepatoma cellsHepatic tissueLipid metabolismObesityInsulinHigh expressionMiR-27Hepatoma cellsSubstrate-1Novel roleLiver
2016
Micro-RNAs and High-Density Lipoprotein Metabolism
Canfrán-Duque A, Lin CS, Goedeke L, Suárez Y, Fernández-Hernando C. Micro-RNAs and High-Density Lipoprotein Metabolism. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36: 1076-1084. PMID: 27079881, PMCID: PMC5315356, DOI: 10.1161/atvbaha.116.307028.BooksConceptsReverse cholesterol transportCardiovascular diseaseHDL metabolismCholesterol transportIschemic heart diseaseCause of deathEarlier epidemiological studiesPotential therapeutic targetBile acid synthesisMicro-RNAsCardioprotective effectsHeart diseaseEpidemiological studiesImproved preventionCholesterol effluxTherapeutic targetDensity lipoproteinCholesterol uptakeDiseaseArtery wallHDL biogenesisInverse correlationHDLLiverAcid synthesis