2010
A Sympathetic View on Free Radicals in Diabetes
Diano S, Horvath TL. A Sympathetic View on Free Radicals in Diabetes. Neuron 2010, 66: 809-811. PMID: 20620864, DOI: 10.1016/j.neuron.2010.06.011.Peer-Reviewed Original ResearchPotential novel therapeutic approachHyperglycemia-induced elevationImpairs synaptic transmissionNovel therapeutic approachesSevere complicationsDiabetic complicationsSympathetic neuronsSynaptic transmissionTherapeutic approachesIssue of NeuronNeuropathyComplicationsDiabetesNeuronsFree radicalsDysautonomiaEtiology
2007
Anticonvulsant effects of leptin in epilepsy
Diano S, Horvath TL. Anticonvulsant effects of leptin in epilepsy. Journal Of Clinical Investigation 2007, 118: 26-28. PMID: 18097479, PMCID: PMC2147676, DOI: 10.1172/jci34511.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAdministration, IntranasalAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsConvulsantsHypothalamusJanus Kinase 2LeptinMaleMiceMice, KnockoutNeuronsPentylenetetrazolePhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPotassium Channel BlockersPotassium Channels, Voltage-GatedRatsRats, Sprague-DawleyReceptors, AMPAReceptors, LeptinSeizuresSynaptic TransmissionConceptsPeripheral metabolic hormonesTreatment of epilepsyRodent seizure modelsHigher brain functionsAnticonvulsant effectsSeizure modelGlutamate neurotransmissionHormone leptinMetabolic hormonesTherapeutic approachesMetabolic disordersNasal epitheliumLeptinAdipose tissueEpileptic seizuresTherapeutic potentialEnergy homeostasisBrain functionNeuronal processesFat storesEpilepsySeizuresEnergy metabolismCritical regulatorDirect effect