2006
Synaptic plasticity mediating leptin's effect on metabolism
Horvath TL. Synaptic plasticity mediating leptin's effect on metabolism. Progress In Brain Research 2006, 153: 47-55. PMID: 16876567, DOI: 10.1016/s0079-6123(06)53002-x.Peer-Reviewed Original ResearchConceptsPrimate hypothalamusSynaptic plasticityEnergy homeostasisShort-term fastingLeptin effectsHypothalamic regulationSynaptic inputsNeuromodulator systemsPeptidergic circuitsHypothalamusNonhuman primatesPathological conditionsBasic wiringMetabolic statePhysiological regulationHomeostasisMetabolic circuitsRodent speciesRatsFastingMicePlasticityResponse
2000
Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary*This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186.
Diano S, Urbanski H, Horvath B, Bechmann I, Kagiya A, Nemeth G, Naftolin F, Warden C, Horvath T. Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary*This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186. Endocrinology 2000, 141: 4226-4238. PMID: 11089557, DOI: 10.1210/endo.141.11.7740.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain ChemistryChlorocebus aethiopsCorticotropin-Releasing HormoneGene ExpressionHypothalamusImmunohistochemistryIn Situ HybridizationIon ChannelsLimbic SystemMacaca fascicularisMacaca mulattaMembrane Transport ProteinsMicroscopy, FluorescenceMitochondrial ProteinsNeuropeptide YOxytocinPituitary GlandPituitary Gland, AnteriorPituitary Gland, PosteriorProteinsRNA, MessengerUncoupling Protein 2VasopressinsConceptsUncoupling protein 2Pituitary glandAnterior lobePrimate brainAxonal processesBrain stem regionsNonhuman primate brainSitu hybridization histochemistryMessenger RNACentral autonomicRR-00163Mitochondrial uncoupling protein 2Neuropeptide YPrimate hypothalamusAnterior pituitaryMetabolic disordersRodent brainPosterior lobeHybridization histochemistryPOMC cellsCell bodiesUCP2 expressionRodent dataNovel targetBrainMitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary**This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186.
Diano S, Urbanski H, Horvath B, Bechmann I, Kagiya A, Nemeth G, Naftolin F, Warden C, Horvath T. Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary**This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186. Endocrinology 2000, 141: 4226-4238. DOI: 10.1210/en.141.11.4226.Peer-Reviewed Original ResearchUncoupling protein 2Pituitary glandPrimate brainIn situ hybridization histochemistryMitochondrial uncoupling protein 2Mitochondrial uncoupling proteinMessenger RNAGH-producing cellsNonhuman primate brainTreatment of metabolic disordersBrain stem regionsUncoupling protein 2 expressionAxonal processesRegulatory componentsUncoupling proteinPrimate hypothalamusPOMC cellsMetabolic regulationArcuate nucleusHybridization histochemistryAnterior pituitaryMitochondrial oxidationStem regionNeuropeptide YPeptide expression
1999
Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations
Horvath T, Diano S, van den Pol A. Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal Of Neuroscience 1999, 19: 1072-1087. PMID: 9920670, PMCID: PMC6782143, DOI: 10.1523/jneurosci.19-03-01072.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsChlorocebus aethiopsEndocrine GlandsFemaleHypothalamusIntracellular Signaling Peptides and ProteinsMaleMetabolismNeural PathwaysNeuronsNeuropeptide YNeuropeptidesOrexin ReceptorsOrexinsRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, G-Protein-CoupledReceptors, LeptinReceptors, NeuropeptideSynapsesConceptsHypothalamic functionCentral regulationHypocretin-containing neuronsLateral hypothalamic cellsLeptin receptor immunoreactivityNeuropeptide Y cellsDirect synaptic contactsNeuropeptide Y systemEndocrine regulationEndocrine processesNPY releaseReceptor immunoreactivityExcitatory actionHypocretin cellsSynaptic contactsArcuate nucleusLateral hypothalamusPrimate hypothalamusLeptin receptorSame neuronsHypothalamic cellsSynaptic regulationAdipose tissueHypocretinNPY
1995
Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase
Herbison A, Horvath T, Naftolin F, Leranth C. Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase. Neuroendocrinology 1995, 61: 1-10. PMID: 7731492, DOI: 10.1159/000126810.Peer-Reviewed Original ResearchConceptsER-immunoreactive cellsHormone-releasing hormoneER immunoreactivityMonkey hypothalamusTyrosine hydroxylaseDouble-labeling experimentsProgesterone receptorDopaminergic neuronesLHRH neuronesEstrogen receptor-immunoreactive cellsReceptor-immunoreactive cellsPituitary hormone secretionSpecific hypothalamic nucleiTH-immunoreactive cellsPR-containing cellsDopamine-containing neuronesHypothalamic dopaminergic neuronesAfrican green monkeysLHRH neuronsPeriventricular areaSteroid statusArcuate nucleusHormone secretionHypothalamic nucleiPrimate hypothalamus