2017
Cannabis in fat: high hopes to treat obesity
Hawkins MN, Horvath TL. Cannabis in fat: high hopes to treat obesity. Journal Of Clinical Investigation 2017, 127: 3918-3920. PMID: 29035279, PMCID: PMC5663345, DOI: 10.1172/jci97042.Peer-Reviewed Original ResearchConceptsCannabinoid receptor type 1Body weightNovel peripheral targetsReduced body weightSystemic metabolic changesAdipocyte-specific deletionReceptor type 1Sympathetic toneTotal adiposityCNS effectsPeripheral mechanismsSystemic metabolismPeripheral targetsAdipocyte physiologyAdipose tissueType 1Metabolic changesMetabolic profileEnergy metabolismMetabolismAdiposityObesityCausal relationshipMiceMacrophages
2016
CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha
Kumamoto Y, Camporez JP, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity 2016, 45: 583-596. PMID: 27566941, PMCID: PMC5033704, DOI: 10.1016/j.immuni.2016.08.002.Peer-Reviewed Original ResearchConceptsMononuclear phagocytesResistin-like molecule αResistin-like molecule alphaSignificant weight lossPositive energy balanceInsulin sensitivityGlucose metabolismAdipose tissueBody weightMultiple organsMultifunctional cytokineBody homeostasisMarked reductionHeterogeneous groupWeight lossPhagocytesMolecule αHomeostasisEnergy balanceRELMαCD301bNormoglycemiaCytokinesMacrophages
2001
Turnover of Rat Brain Perivascular Cells
Bechmann I, Kwidzinski E, Kovac A, Simbürger E, Horvath T, Gimsa U, Dirnagl U, Priller J, Nitsch R. Turnover of Rat Brain Perivascular Cells. Experimental Neurology 2001, 168: 242-249. PMID: 11259112, DOI: 10.1006/exnr.2000.7618.Peer-Reviewed Original ResearchConceptsBrain perivascular spacesBone marrow transplantationPerivascular spacesPerivascular cellsMarrow transplantationAdult ratsBlood borne macrophagesBrain perivascular cellsHealthy adult ratsEx vivo isolationMonocyte/macrophage lineageHigh phagocytic capacityNormal adult ratsMHC mismatchIntraventricular injectionBrain parenchymaIntracerebral injectionAntigen presentationImmune surveillanceDonor macrophagesPhagocytic capacityMacrophage lineageMacrophagesVivo isolationSame animals