2005
A Novel Growth Hormone Secretagogue-1a Receptor Antagonist That Blocks Ghrelin-Induced Growth Hormone Secretion but Induces Increased Body Weight Gain
Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath TL, Culler MD. A Novel Growth Hormone Secretagogue-1a Receptor Antagonist That Blocks Ghrelin-Induced Growth Hormone Secretion but Induces Increased Body Weight Gain. Neuroendocrinology 2005, 81: 339-349. PMID: 16210868, DOI: 10.1159/000088796.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArea Under CurveBehavior, AnimalBinding, CompetitiveBody WeightBrainCell CountCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugDrug InteractionsFeeding BehaviorGhrelinGrowth HormoneHumansImmunohistochemistryIodine IsotopesMaleOncogene Proteins v-fosPeptide HormonesRatsRats, Sprague-DawleyReceptors, GhrelinReceptors, G-Protein-CoupledTime FactorsConceptsDorsal medial hypothalamusGHS-1a receptorGrowth hormone secretionBIM-28163Fos-IRWeight gainGH secretionHormone secretionGrowth hormone secretagogue 1a receptorAntagonist of ghrelinMedial arcuate nucleusAction of ghrelinFos protein immunoreactivityAnti-obesity strategiesBody weight gainGhrelin activationConcomitant administrationGhrelin actionMedial hypothalamusArcuate nucleusReceptor antagonistGhrelin receptorFood intakeProtein immunoreactivityHuman ghrelin
2003
Ghrelin in hypothalamic regulation of energy balance.
Horvath TL, Diano S, Tschöp M. Ghrelin in hypothalamic regulation of energy balance. Current Topics In Medicinal Chemistry 2003, 3: 921-7. PMID: 12678840, DOI: 10.2174/1568026033452230.Peer-Reviewed Original Research
1997
Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine.
Horvath T. Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine. Endocrinology 1997, 138: 1312-20. PMID: 9048641, DOI: 10.1210/endo.138.3.4976.Peer-Reviewed Original ResearchConceptsPituitary hormone secretionVasculosum laminae terminalisSuprachiasmatic nucleusHormone secretionNeuroendocrine cellsPreoptic areaLamina terminalisDopamine cellsMedian eminenceAnterior pituitary hormone secretionMedial preoptic areaDiffuse cytoplasmic labelingPhaseolus vulgaris leukoagglutininFluorogold labelingPeriventricular areaArcuate nucleusHypothalamic sitesIP administrationVentromedial nucleusAnterior hypothalamusAnterograde tracerAxon terminalsPeriventricular regionElectron microscopic examinationTyrosine hydroxylase
1995
Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus
Horvath T, Kalra S, Naftolin F, Leranth C. Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus. Journal Of Neuroendocrinology 1995, 7: 579-588. PMID: 8704731, DOI: 10.1111/j.1365-2826.1995.tb00795.x.Peer-Reviewed Original ResearchConceptsBeta-endorphin cellsBeta-endorphin neuronsArcuate nucleusBeta-endorphinMediobasal hypothalamusImmunoreactive profilesPituitary hormone secretionBeta-endorphin releaseDay survival periodRat mediobasal hypothalamusDiaminobenzidine reactionGalanin fibersHalász knifeImmunoreactive neuronsHormone secretionContralateral sideFemale ratsHypothalamic galaninProlactin secretionAdditional ratsElectron microscopic examinationPituitary hormonesSurvival periodNeuroendocrine responsesGalaninGalanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus
Horvath T, Leranth C, Kalra S, Naftolin F. Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus. Brain Research 1995, 675: 321-324. PMID: 7540929, DOI: 10.1016/0006-8993(94)01374-q.Peer-Reviewed Original ResearchConceptsPituitary hormone secretionEstrogen receptorHormone secretionMediobasal hypothalamusEstrogen receptor immunoreactivityHypothalamic luteinizing hormoneArcuate nucleus neuronsRat mediobasal hypothalamusPopulations of neuronsGalanin neuronsReceptor immunoreactivityOvarian steroidsEstrogen effectsNucleus neuronsLuteinizing hormoneFemale ratsHormone releaseGalaninHypothalamusNeuronsVibratome sectionsImmunoreactivityReceptorsHormoneSecretionDistribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase
Herbison A, Horvath T, Naftolin F, Leranth C. Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase. Neuroendocrinology 1995, 61: 1-10. PMID: 7731492, DOI: 10.1159/000126810.Peer-Reviewed Original ResearchConceptsER-immunoreactive cellsHormone-releasing hormoneER immunoreactivityMonkey hypothalamusTyrosine hydroxylaseDouble-labeling experimentsProgesterone receptorDopaminergic neuronesLHRH neuronesEstrogen receptor-immunoreactive cellsReceptor-immunoreactive cellsPituitary hormone secretionSpecific hypothalamic nucleiTH-immunoreactive cellsPR-containing cellsDopamine-containing neuronesHypothalamic dopaminergic neuronesAfrican green monkeysLHRH neuronsPeriventricular areaSteroid statusArcuate nucleusHormone secretionHypothalamic nucleiPrimate hypothalamus
1993
Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study
Horvath TL, Shanabrough M, Naftolin F, Leranth C. Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study. Endocrinology 1993, 133: 405-414. PMID: 8100520, DOI: 10.1210/endo.133.1.8100520.Peer-Reviewed Original ResearchConceptsTyrosine hydroxylase-immunoreactive neuronsHydroxylase-immunoreactive neuronsProgesterone receptorSynaptic contactsAxon terminalsDopamine cellsTyrosine hydroxylase-immunopositive cellsHypophyseal hormone secretionEffects of NPYDorsomedial hypothalamic nucleusCoronal vibratome sectionsNuclear progesterone receptorPR-containing cellsAfrican green monkeysDiaminobenzidine reactionNPY axonsPeriventricular areaOVX animalsHormone secretionMonkey hypothalamusAnterior hypothalamusHypothalamic nucleiDopamine neuronsPRL releaseEstrogenNeuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study
Horvath T, Shanabrough M, Naftolin F, Leranth C. Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study. Endocrinology 1993, 133: 405-414. DOI: 10.1210/en.133.1.405.Peer-Reviewed Original ResearchTyrosine hydroxylase-immunoreactive neuronsNPY-immunoreactive axon terminalsProgesterone receptorNeuropeptide-YDopamine cellsFrequency of synaptic contactsLight brown diaminobenzidine reactionTyrosine hydroxylase-immunopositive cellsNPY-immunoreactive boutonsPR-containing cellsSynaptic contactsNuclear progesterone receptorDorsomedial hypothalamic nucleusEstrogen-treated monkeysHypophyseal hormone secretionAxon terminalsEffects of neuropeptide-YCoronal vibratome sectionsAfrican green monkeysPRL releaseOVX animalsDopamine neuronsMonkey hypothalamusHormone secretionHypothalamic nuclei
1992
Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study
Horvath TL, Naftolin F, Leranth C. Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology 1992, 131: 1547-1555. PMID: 1354605, DOI: 10.1210/endo.131.3.1354605.Peer-Reviewed Original ResearchConceptsDopamine neuronsZona incertaDopamine cellsSynaptic connectionsCell bodiesDouble immunostaining experimentsHypophyseal hormone secretionHypothalamic dopaminergic systemFemale rat brainHypothalamic dopaminergic neuronsDorsomedial hypothalamic nucleusDopamine cell bodiesReceptor-containing cellsDouble immunostaining studiesLight microscopic examinationPutative synaptic connectionsLH releaseDopamine innervationImmunoreactive boutonsPeriventricular areaDopaminergic neuronsPRL secretionSynaptic contactsArcuate nucleusHormone secretion