Cannabinoids, opioids and eating behavior: The molecular face of hedonism?
Cota D, Tschöp MH, Horvath TL, Levine AS. Cannabinoids, opioids and eating behavior: The molecular face of hedonism? Brain Research Reviews 2005, 51: 85-107. PMID: 16364446, DOI: 10.1016/j.brainresrev.2005.10.004.Peer-Reviewed Original ResearchConceptsOpioid receptor antagonistPrevalence of obesityAnti-obesity drugsAnti-obesity therapiesCentral nervous mechanismsAddictive componentOpioid systemReceptor antagonistEnergy balance controlFood intakeNervous mechanismsAddictive propertiesEnergy homeostasisHealth threatLife expectancyBody of dataRewarding valueAlarming increaseObesityBalance controlHomeostatic componentWestern countriesFunctional interactionHedonic aspectsOpioidsObesity and the Neuroendocrine Control of Energy Homeostasis: The Role of Spontaneous Locomotor Activity 1
Castañeda TR, Jürgens H, Wiedmer P, Pfluger P, Diano S, Horvath TL, Tang-Christensen M, Tschöp MH. Obesity and the Neuroendocrine Control of Energy Homeostasis: The Role of Spontaneous Locomotor Activity 1. Journal Of Nutrition 2005, 135: 1314-1319. PMID: 15867332, DOI: 10.1093/jn/135.5.1314.Peer-Reviewed Original ResearchConceptsSpontaneous physical activityWidespread sedentary lifestylesIntolerable side effectsPrevalence of obesityFat mass accumulationCause of deathUrgent global health threatGlobal health threatSafe therapyFat massPharmacological reductionPhysical activitySedentary lifestyleSide effectsEnergy intakeNeuroendocrine factorsNeuroendocrine controlEnergy homeostasisObesityHealth threatMajor predictorActivity 1Molecular mechanismsLow levelsMajor contributor