2004
Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates
Leranth C, Prange-Kiel J, Frick KM, Horvath TL. Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates. Cerebral Cortex 2004, 14: 503-510. PMID: 15054066, DOI: 10.1093/cercor/bhh012.Peer-Reviewed Original ResearchConceptsSpine synapse densitySynapse densityNon-human primatesSpine synapsesCA1 spine synapse densityPyramidal cell apical dendritesCA1 hippocampal areaCell apical dendritesCA1 stratum radiatumFemale non-human primatesMale non-human primatesMale primatesOrchidectomized animalsApical dendritesCA1 areaDendritic shaftsHippocampal areaStratum radiatumGonadal hormonesControl monkeysMale hippocampusGonadectomized animalsOvariectomized femalesAndrogen hormonesPrimate hippocampus
2000
Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Leranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.Peer-Reviewed Original ResearchConceptsNigrostriatal dopamine neuronsDopamine neuronsParkinson's diseaseSubstantia nigraDopamine cellsTyrosine hydroxylase-expressing neuronsTyrosine hydroxylase-immunoreactive cellsNigral dopamine systemsEstrogen replacement therapyNew treatment strategiesUnbiased stereological analysisTypes of neuronsProgression of diseaseEstrogen replacementPostmenopausal womenEstrogen deprivationReplacement therapyTreatment strategiesCompact zoneGonadal hormonesLong-term effectsDopamine systemEstrogenDiseaseNeurons
1999
Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat
Leranth C, Shanabrough M, Horvath T. Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat. Experimental Brain Research 1999, 128: 417-420. PMID: 10501815, DOI: 10.1007/s002210050863.Peer-Reviewed Original ResearchConceptsEstrogen receptorLong-term potentiationMedian rapheSupramammillary areaSubcortical structuresCalretinin-containing neuronsHippocampal long-term potentiationEffects of estrogenHippocampal electric activityCalretinin neuronsFemale ratsGonadal hormonesTheta rhythmRapheVibratome sectionsReceptorsNeuronsSerotoninElectric activityEstrogenRhythm regulationPotentiationLarge populationMemory processesCalretinin