2017
Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum
Zsarnovszky A, Kiss D, Jocsak G, Nemeth G, Toth I, Horvath TL. Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum. Frontiers In Neuroendocrinology 2017, 48: 23-36. PMID: 28987779, DOI: 10.1016/j.yfrne.2017.10.001.Peer-Reviewed Original ResearchConceptsEffects of phytoestrogensThyroid hormonesBrain functionNormal physiological settingsMetabolic parametersMature brainEstrogen receptor interactionSteroid hormonesBrain developmentHormoneHomeostatic parametersIntercellular actionsHormonal mechanismsReceptor interactionNatural ligandEnergy metabolismCerebellumEndocrine disruptorsPhytoestrogensPivotal rolePhysiological settingsMetabolismGliaEstrogenNeurons
2016
Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine
Jocsak G, Kiss DS, Toth I, Goszleth G, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine. International Journal Of Environmental Research And Public Health 2016, 13: 619. PMID: 27338438, PMCID: PMC4924076, DOI: 10.3390/ijerph13060619.Peer-Reviewed Original ResearchConceptsERβ mRNA expressionModulatory roleMRNA expressionCerebellar cell culturesGlial cellsEstrogen receptor β mRNA expressionEndocrine disruptorsAbsence of E2ED effectsPrimary cerebellar cell culturesΒ mRNA expressionAdverse health effectsHormonal milieuBody of evidenceHormone deficiencyCell culturesTriiodo-ThyronineHealth effectsEnvironmental substancesSimultaneous exposureEstradiolComparison of individualsObserved potencyE2T3