The Beta-1 Adrenergic Antagonist, Betaxolol, Improves Working Memory Performance in Rats and Monkeys
Ramos BP, Colgan L, Nou E, Ovadia S, Wilson SR, Arnsten AF. The Beta-1 Adrenergic Antagonist, Betaxolol, Improves Working Memory Performance in Rats and Monkeys. Biological Psychiatry 2005, 58: 894-900. PMID: 16043136, DOI: 10.1016/j.biopsych.2005.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-1 Receptor AntagonistsAdrenergic beta-AntagonistsAnimalsAttentionBetaxololCognitionDose-Response Relationship, DrugHypnotics and SedativesMacaca mulattaMaleMaze LearningMemory, Short-TermMicroinjectionsPancreatic DiseasesPrefrontal CortexPsychomotor PerformanceRatsStereotaxic TechniquesConceptsMemory performancePrefrontal cortexPost-traumatic stress disorderPFC cognitive functionCognitive functioningStress disorderAlternation testingCognitive functionPFC functionBeta-1 adrenergic antagonistBeta 2 receptorsPFC dysfunctionPancreatic side effectsPFC infusionAged monkeysNoradrenergic activityCurrent studySelective beta 1 antagonistDose-related improvementBeta 1Beta 1/betaBeta-adrenergic receptor stimulationBeta-1 antagonistAdrenergic receptor stimulationWarrants further investigationSuccessful cyclosporine treatment for atopic dermatitis in a rhesus macaque (Macaca mulatta).
Ovadia S, Wilson SR, Zeiss CJ. Successful cyclosporine treatment for atopic dermatitis in a rhesus macaque (Macaca mulatta). Comparative Medicine 2005, 55: 192-6. PMID: 15884783.Peer-Reviewed Original ResearchConceptsAtopic dermatitisSkin conditionsRhesus macaquesMonths of treatmentHistory of allergyInflammatory skin conditionFemale rhesus macaquesSuccessful therapeutic agentsCyclosporine treatmentOral cyclosporineImmunological injuryCalcineurin inhibitorsChronic courseImmunomodulatory drugsMetabolic abnormalitiesClinical evidenceLymphocyte functionSuccessful treatmentComplete hemogramDifferential diagnosisNormal limitsSuccessful therapyInguinal regionAllergic dermatitisDistal extremities