2011
Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein HC, Murray AM, Sullivan M, Horowitz KR, Ding J, Marcovina S, Lovato LC, Lovato J, Margolis KL, O'Connor P, Lipkin EW, Hirsch J, Coker L, Maldjian J, Sunshine JL, Truwit C, Davatzikos C, Bryan RN, investigators F. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. The Lancet Neurology 2011, 10: 969-977. PMID: 21958949, PMCID: PMC3333485, DOI: 10.1016/s1474-4422(11)70188-0.Peer-Reviewed Original ResearchConceptsTotal brain volumeType 2 diabetesIntensive treatment groupIntensive treatmentStandard treatmentGlycaemic controlDSST scoresTreatment groupsBrain volumeDigit Symbol Substitution Test scoreHigher glycated hemoglobinIntensive glycaemic controlOpen-label substudyStandard glycaemic controlStandard treatment groupUS National HeartMonth outcome measuresSubset of participantsSignificant treatment differencesACCORD studyCardiovascular eventsCardiovascular riskIntensive glucoseBrain atrophyIntensive therapy
2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
Mitsumoto H, Ulu A, Pullman S, Gooch C, Chan S, Tang M, Mao X, Hays A, Floyd A, Battista V, Montes J, Hayes S, Dashnaw S, Kaufmann P, Gordon P, Hirsch J, Levin B, Rowland L, Shungu D. Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007, 68: 1402-1410. PMID: 17452585, DOI: 10.1212/01.wnl.0000260065.57832.87.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisAspartic AcidBiomarkersCreatineDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMotor CortexMotor Neuron DiseaseMotor NeuronsMuscular Atrophy, SpinalNeural ConductionProspective StudiesTranscranial Magnetic StimulationConceptsMotor unit number estimationCentral motor conduction timeMotor conduction timeAcetyl-aspartate concentrationsUMN syndromeControl subjectsTibialis anteriorConduction timeObjective markersLower motor neuron dysfunctionLower motor neuron involvementALS Functional RatingMotor neuron involvementMotor neuron dysfunctionProton MR spectroscopic imagingTranscranial magnetic stimulationRatio of NAADiffusion tensor imagingLMN syndromesDisease activityNeuron involvementNeuron dysfunctionMR spectroscopic imagingFunctional ratingObjective biomarkers
2006
Cortical reorganization following intradigital tendon transfer
Viswanathan V, Chmayssani M, Adams DJ, Hirsch J. Cortical reorganization following intradigital tendon transfer. Neuroreport 2006, 17: 1669-1673. PMID: 17047451, DOI: 10.1097/01.wnr.0000239953.60695.08.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overBrain MappingFingersHumansMagnetic Resonance ImagingMaleMotor CortexMotor SkillsNeuronal PlasticityTendonsHemodynamic Impairment as a Stimulus for Functional Brain Reorganization
Marshall RS, Krakauer JW, Matejovsky T, Zarahn E, Barnes A, Lazar RM, Hirsch J. Hemodynamic Impairment as a Stimulus for Functional Brain Reorganization. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1256-1262. PMID: 16421509, DOI: 10.1038/sj.jcbfm.9600274.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrain InfarctionHemodynamicsHumansMagnetic Resonance ImagingMiddle AgedConceptsVasomotor reactivityHemodynamic impairmentMotor-related activityControl subjectsFunctional reorganizationMotor regionsLevel-dependent signal intensityAbnormal cerebral hemodynamicsTypical motor activitiesLarge vessel occlusionSubgroup of patientsBlood oxygen level-dependent (BOLD) signal intensityContralateral motor areasFunctional brain reorganizationCarbon dioxide inhalationSimple motor taskFunctional magnetic resonanceAbnormal vasoreactivityTranscranial DopplerBrain reorganizationVessel occlusionCerebral hemodynamicsHand contralateralMotor areaFocal lesions
2004
Hypoperfusion without stroke alters motor activation in the opposite hemisphere
Krakauer JW, Radoeva PD, Zarahn E, Wydra J, Lazar RM, Hirsch J, Marshall RS. Hypoperfusion without stroke alters motor activation in the opposite hemisphere. Annals Of Neurology 2004, 56: 796-802. PMID: 15562431, DOI: 10.1002/ana.20286.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCerebrovascular DisordersHumansMagnetic Resonance ImagingMiddle AgedMotor CortexMotor SkillsStrokeConceptsIpsilateral activationMiddle cerebral artery diseaseCerebral artery diseaseLarge vessel diseaseAge-matched controlsMotor-related areasNormal motor performanceFunctional magnetic resonanceHemodynamic compromiseVasomotor reactivityArtery diseaseHemispheric hypoperfusionCortical reorganizationInternal carotidHand contralateralPatientsMotor activationMotor tasksMotor performanceHypoperfusionHemispheric activationUnique activationDiseaseActivationMagnetic resonance
1991
Assessment of potential contrast sensitivity Part 1: Preoperative prediction of contrast sensitivity following intraocular lens implantation
Morris M, Klett Z, Gieser S, Couch J, Hirsch J. Assessment of potential contrast sensitivity Part 1: Preoperative prediction of contrast sensitivity following intraocular lens implantation. Journal Of Cataract & Refractive Surgery 1991, 17: 37-44. PMID: 2005557, DOI: 10.1016/s0886-3350(13)80982-0.Peer-Reviewed Original ResearchConceptsPostoperative contrast sensitivity functionPreoperative visual acuityContrast sensitivity functionPreoperative visual acuity of 20/200Contrast sensitivityMild to moderate cataractsVisual acuity of 20/200Postoperative contrast sensitivityAcuity of 20/200Intraocular lens implantationModerate cataractLens implantationVisual acuityCataract patientsLens opacitiesPostoperative complicationsPreoperative measurementsPreoperative predictionCataractPatientsEyesAcuityComplicationsAssessment of contrast sensitivity Part II: The relationship between objective lens opacity and laser interferometric contrast sensitivity in the cataract patient
Klett Z, Morris M, Gieser S, Couch J, Hirsch J. Assessment of contrast sensitivity Part II: The relationship between objective lens opacity and laser interferometric contrast sensitivity in the cataract patient. Journal Of Cataract & Refractive Surgery 1991, 17: 45-57. PMID: 2005558, DOI: 10.1016/s0886-3350(13)80983-2.Peer-Reviewed Original ResearchConceptsLens opacitiesContrast sensitivityRetinal functionLaser interferometric measurementMeasure retinal functionPreoperative lens opacitiesRetinal contrast sensitivityOpacity lensmeterCataract densityCataract populationCataract patientsCataract typeImmature cataractCataractPatientsInverse linear relationshipOpacitySensitivityLensmeterCorrelation coefficient
1990
Assessment of Visual-Field Changes before and after Focal Photocoagulation for Clinically Significant Diabetic Macular Edema
Sims L, Stoessel K, Thompson J, Hirsch J. Assessment of Visual-Field Changes before and after Focal Photocoagulation for Clinically Significant Diabetic Macular Edema. Ophthalmologica 1990, 200: 133-141. PMID: 2345627, DOI: 10.1159/000310094.Peer-Reviewed Original Research