2023
Uncertainty in learning and decision-making: Introduction to the special issue
Levy I, Schiller D. Uncertainty in learning and decision-making: Introduction to the special issue. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 459-464. PMID: 37222931, DOI: 10.3758/s13415-023-01111-6.Peer-Reviewed Original ResearchNeural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
2017
Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments
Zhang Z, Fanning J, Ehrlich DB, Chen W, Lee D, Levy I. Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments. Nature Communications 2017, 8: 1907. PMID: 29203854, PMCID: PMC5714958, DOI: 10.1038/s41467-017-02080-4.Peer-Reviewed Original ResearchConceptsNeural representationAnticipation of rewardDecision-related informationCognitive neuroscienceOutcome anticipationValue signalsPotential confoundsCategory informationHuman brainNeural signalsSaliencyRewardValuation taskAnticipationMultiple aspectsStrong supportActivity patternsPunishmentVmPFCRepresentationNeuroscienceConfoundsExtensive literatureEncodingTask
2016
Neuroanatomy accounts for age-related changes in risk preferences
Grubb MA, Tymula A, Gilaie-Dotan S, Glimcher PW, Levy I. Neuroanatomy accounts for age-related changes in risk preferences. Nature Communications 2016, 7: 13822. PMID: 27959326, PMCID: PMC5159889, DOI: 10.1038/ncomms13822.Peer-Reviewed Original ResearchConceptsRight posterior parietal cortexGray matter volumeRisky rewardMatter volumeAge-related changesLess grey matter volumePosterior parietal cortexAge-related declineRisk preferencesNeural mechanismsRisky choiceParietal regionsParietal cortexSubstantial empirical evidenceOlder adultsHealthy agingYoung adultsRewardGray matter lossEmpirical evidencePotential outcomesHuman agingAdultsPreferencesNeuroanatomy
2014
Impaired Associative Learning with Food Rewards in Obese Women
Zhang Z, Manson KF, Schiller D, Levy I. Impaired Associative Learning with Food Rewards in Obese Women. Current Biology 2014, 24: 1731-1736. PMID: 25042588, DOI: 10.1016/j.cub.2014.05.075.Peer-Reviewed Original ResearchConceptsObese womenReward-based associative learningLearning deficitsBody mass indexHigh-calorie foodsObese menObese participantsMass indexFood rewardObesityReward circuitRewarding propertiesCue-reward associationsMajor epidemicsType of foodSuch impairmentImpairmentWomenMultiple regression analysisRegression analysisDysfunctionFemale participantsAssociative learningMoney rewardsNegative association