Publications

2025

Joint modeling of mixed outcomes using a rank-based sparse neural network
Xue J, Xu Y, Li J, Ma S, Fang K. Joint modeling of mixed outcomes using a rank-based sparse neural network. Journal Of Biomedical Informatics 2025, 104870. PMID: 40623577, DOI: 10.1016/j.jbi.2025.104870.
Peer-Reviewed Original Research
JACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023)
Yan B, Arun A, Curtis L, Kadakia K, Lin Z, Lu Y, Wadhera R, Krumholz H, Dhruva S. JACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023). Journal Of The American College Of Cardiology 2025, 85: 2495-2498. PMID: 40562514, DOI: 10.1016/j.jacc.2025.05.018.
Peer-Reviewed Original Research
AAnet resolves a continuum of spatially-localized cell states to unveil intratumoral heterogeneity.
Venkat A, Youlten S, San Juan B, Purcell C, Gupta S, Amodio M, Neumann D, Lock J, Westacott A, McCool C, Burkhardt D, Benz A, Mollbrink A, Lundeberg J, van Dijk D, Holst J, Goldstein L, Kummerfeld S, Krishnaswamy S, Chaffer C. AAnet resolves a continuum of spatially-localized cell states to unveil intratumoral heterogeneity. Cancer Discovery 2025 PMID: 40552975, DOI: 10.1158/2159-8290.cd-24-0684.
Peer-Reviewed Original Research
Concepts
Use of Present-on-Admission Indicators to Improve Accuracy of Pulmonary Embolism Identification from Electronic Health Record Data
Rashedi S, Leyva H, Pfeferman M, Krishnathasan D, Bejjani A, Khairani C, Zarghami M, Jimenez D, Muriel A, Goldhaber S, Wang L, Secemsky E, Piazza G, Krumholz H, Lin Z, Bikdeli B. Use of Present-on-Admission Indicators to Improve Accuracy of Pulmonary Embolism Identification from Electronic Health Record Data. Seminars In Thrombosis And Hemostasis 2025 PMID: 40555267, DOI: 10.1055/a-2554-0043.
Peer-Reviewed Original Research
Concepts
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
Kim C, Ross J, Jastreboff A, Meeker D, Freedman H, Krumholz H, Lu Y. Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US. JAMA 2025, 333: 2203-2206. PMID: 40299371, PMCID: PMC12042086, DOI: 10.1001/jama.2025.4735.
Peer-Reviewed Original Research
Concepts
Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis
Nguyen H, Shabanova V, McCollum S, Polk B, Lee T, Whittington K, Cunha P, Bruscia E, Egan M, Emmenegger M, Leeds S. Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis. Annals Of Allergy Asthma & Immunology 2025 PMID: 40550267, DOI: 10.1016/j.anai.2025.06.024.
Peer-Reviewed Original Research
Concepts
Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study
Amat J, Dudgeon S, Cheemarla N, Watkins T, Green A, Young H, Peaper D, Landry M, Schulz W, Foxman E. Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study. EBioMedicine 2025, 117: 105820. PMID: 40543450, PMCID: PMC12216728, DOI: 10.1016/j.ebiom.2025.105820.
Peer-Reviewed Original Research
Concepts
Neuroimmune pathophysiology of long COVID
Moen J, Baker C, Iwasaki A. Neuroimmune pathophysiology of long COVID. Psychiatry And Clinical Neurosciences 2025 PMID: 40536011, DOI: 10.1111/pcn.13855.
Peer-Reviewed Original Research
Concepts
Lipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Lipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic. JACC Advances 2025, 4: 101872. PMID: 40513221, PMCID: PMC12205634, DOI: 10.1016/j.jacadv.2025.101872.
Peer-Reviewed Original Research
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans
Marini-Rapoport O, Andrieux L, Keswani T, Zong G, Duchen D, Yaari G, Min J, Lytle I, Rosenberg A, Fucile C, Kobie J, Piepenbrink M, Sun T, Martin V, Yuan Q, Shreffler W, Seppo A, Järvinen K, Loeffler J, Ward A, Kleinstein S, Pedersen L, Fernández-Quintero M, Mueller G, Patil S. Germline-encoded recognition of peanut underlies development of convergent antibodies in humans. Science Translational Medicine 2025, 17: eadw4148. PMID: 40498852, DOI: 10.1126/scitranslmed.adw4148.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Firearm Laws and Pediatric Mortality in the US
Faust J, Chen J, Bhat S, Otugo O, Yaver M, Renton B, Chen A, Lin Z, Krumholz H. Firearm Laws and Pediatric Mortality in the US. JAMA Pediatrics 2025, 179 PMID: 40489107, PMCID: PMC12150223, DOI: 10.1001/jamapediatrics.2025.1363.
Peer-Reviewed Original Research
Concepts
FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer
Ji L, Pu L, Wang J, Cao H, Melemenidis S, Sinha S, Guan L, Laseinde E, von Eyben R, Richter S, Nam J, Kong C, Casey K, Graves E, Frock R, Le Q, Rankin E. FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer. JCI Insight 2025, 10: e184968. PMID: 40485587, DOI: 10.1172/jci.insight.184968.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Phylogenetic insights into the transmission dynamics of arthropod-borne viruses
Hill V, Dellicour S, Giovanetti M, Grubaugh N. Phylogenetic insights into the transmission dynamics of arthropod-borne viruses. Nature Reviews Genetics 2025, 1-15. PMID: 40481331, DOI: 10.1038/s41576-025-00854-x.
Peer-Reviewed Original Research
Concepts
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
Sewall L, de Paiva Froes Rocha R, Gibson G, Louie M, Xie Z, Bangaru S, Tran A, Ozorowski G, Mohanty S, Beutler N, Rogers T, Burton D, Shaw A, Batista F, Chocarro Ruiz B, Torrents de la Peña A, Ward A. Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes. Nature Biomedical Engineering 2025, 1-14. PMID: 40461656, DOI: 10.1038/s41551-025-01411-x.
Peer-Reviewed Original Research
Concepts
Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States.
Chu L, Wang R, Gross C, Wei J, Lu Y, Krumholz H, Ma X, Chen K. Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation 2025 PMID: 40458867, DOI: 10.1161/circulationaha.124.073614.
Peer-Reviewed Original Research
Concepts
Cysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Li Z, Spatz E, Krumholz H, Lu Y. Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores. JAMA Network Open 2025, 8: e2516663. PMID: 40531529, PMCID: PMC12177675, DOI: 10.1001/jamanetworkopen.2025.16663.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
ENaC contributes to macrophage dysfunction in cystic fibrosis
Moran J, Pugh C, Brown N, Thomas A, Zhang S, McCauley E, Cephas A, Shrestha C, Partida-Sanchez S, Bai S, Bruscia E, Kopp B. ENaC contributes to macrophage dysfunction in cystic fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 329: l61-l69. PMID: 40454714, PMCID: PMC12181047, DOI: 10.1152/ajplung.00009.2025.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Advancing Prognostic Enrichment in Pediatric Sepsis-Associated Acute Respiratory Dysfunction
Pierce R, Sallee C. Advancing Prognostic Enrichment in Pediatric Sepsis-Associated Acute Respiratory Dysfunction. CHEST Critical Care 2025, 3: 100140. DOI: 10.1016/j.chstcc.2025.100140.
Peer-Reviewed Original Research
Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms
Dhingra L, Aminorroaya A, Pedroso A, Khunte A, Sangha V, McIntyre D, Chow C, Asselbergs F, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms. JAMA Cardiology 2025, 10: 574-584. PMID: 40238120, PMCID: PMC12004248, DOI: 10.1001/jamacardio.2025.0492.
Peer-Reviewed Original Research
Concepts
10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population
Faridi K, Malik D, Essa M, Yang H, Spatz E, Krumholz H, Lu Y. 10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population. Journal Of The American College Of Cardiology 2025, 85: 2239-2249. PMID: 40499978, DOI: 10.1016/j.jacc.2025.03.546.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Update to the JACC Report Card: Excess Cardiovascular Mortality Among Black Americans, 2000–2023
Arun A, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols M, Yancy C, Krumholz H. Update to the JACC Report Card: Excess Cardiovascular Mortality Among Black Americans, 2000–2023. Journal Of The American College Of Cardiology 2025 DOI: 10.1016/j.jacc.2025.06.008.
Peer-Reviewed Original Research
The Role of Cardiovascular Disease Journals in Reporting Sex and Gender in Research
Merz C, Bonow R, Carnethon M, Crea F, Hill J, Krumholz H, Mehran R, Spatz E. The Role of Cardiovascular Disease Journals in Reporting Sex and Gender in Research. JAMA Cardiology 2025, 10: 529-530. PMID: 40152760, DOI: 10.1001/jamacardio.2025.0788.
Peer-Reviewed Original Research
The Reply
Zhou T, Sawano M, Krumholz H. The Reply. The American Journal Of Medicine 2025, 138: e118. PMID: 40390476, DOI: 10.1016/j.amjmed.2024.09.008.
Peer-Reviewed Original Research
Antiplatelet and Anticoagulant Therapy in the 2025 ACC/AHA Guideline for Acute Coronary Syndromes Key Recommendations
Bikdeli B, Ujueta F, Rashedi S, Talasaz A, Kadakia K, Lopes R, White H, Steg P, Piazza G, Al-Lamee R, Cohen D, Mehran R, Krumholz H. Antiplatelet and Anticoagulant Therapy in the 2025 ACC/AHA Guideline for Acute Coronary Syndromes Key Recommendations. Journal Of The American College Of Cardiology 2025, 85: 2074-2078. PMID: 40467132, DOI: 10.1016/j.jacc.2025.04.002.
Peer-Reviewed Original Research

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