2022
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression
Arshad N, Laurent-Rolle M, Ahmed W, Hsu J, Mitchell S, Pawlak J, Sengupta D, Biswas K, Cresswell P. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2208525120. PMID: 36574644, PMCID: PMC9910621, DOI: 10.1073/pnas.2208525120.Peer-Reviewed Original ResearchConceptsMHC-I expressionSARS-CoV-2Major histocompatibility complex (MHC) class I moleculesT cell recognitionVirus-infected cellsClass I moleculesAntigen presentationOngoing COVID-19 pandemicHeavy chainImmune evasionViral peptidesSecretory pathwayDistinct mechanismsMHCI moleculesPeptide-MHCInfected cellsCausative agentCell recognitionCD8COVID-19 pandemicViral proteinsEndoplasmic reticulumHuman MHCORF7a
2003
Inhibition of interferon signaling by dengue virus
Muñoz-Jordán J, Sánchez-Burgos GG, Laurent-Rolle M, García-Sastre A. Inhibition of interferon signaling by dengue virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14333-14338. PMID: 14612562, PMCID: PMC283592, DOI: 10.1073/pnas.2335168100.Peer-Reviewed Original ResearchConceptsPositive-strand RNA genomeExpression of NS4BPositive-strand RNA virusesNuclear signal transducerVirus-encoded proteinsStrand RNA virusesStrand RNA genomeHuman A549 cellsDengue virusRNA genomeDengue virus-infected cellsSignal transducerTranscription 1Gene expressionUnknown functionVirus-infected cellsInhibition of interferonRNA virusesDengue virus infectionNS4BMosquito-borne flavivirusProteinA549 cellsIFN responseViral products