2013
Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss M, Jensen J, Kowalik T. Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection. PLOS Genetics 2013, 9: e1003735. PMID: 24086142, PMCID: PMC3784496, DOI: 10.1371/journal.pgen.1003735.Peer-Reviewed Original ResearchConceptsPositive selectionCongenital HCMV infectionApplication of population genetic methodsHuman cytomegalovirus evolutionViral populationsPopulation genetic methodsPopulation genetic approachesHuman cytomegalovirusModels of demographyOpen reading frameHCMV populationsHCMV infectionPatterns of variationUnrelated hostsReading frameGenome populationsWeeks gestational ageGenetic approachesGenetic methodsDNA virusesHuman hostPervasive driverHost environmentCompartmental variablesViral evolution
2010
Association of viral load with HPV16 positive cervical cancer pathogenesis: Causal relevance in isolates harboring intact viral E2 gene
Das D, Bhattacharjee B, Sen S, Mukhopadhyay I, Sengupta S. Association of viral load with HPV16 positive cervical cancer pathogenesis: Causal relevance in isolates harboring intact viral E2 gene. Virology 2010, 402: 197-202. PMID: 20394955, DOI: 10.1016/j.virol.2010.03.030.Peer-Reviewed Original ResearchConceptsViral loadE2 statusAssociation of viral loadMedian viral loadViral loads compared to controlsAge of subjectsCervical cancer pathogenesisViral E2 geneCompared to controlsCervical cancerLogistic regression modelsCancer pathogenesisTaqMan assayLower ageCaCxHPV16E2 genePathogenesisAgeIntact E2Regression modelsStatusGenomic DNAAssociationCancer
2008
Characterization of sequence variations within HPV16 isolates among Indian women: Prediction of causal role of rare non-synonymous variations within intact isolates in cervical cancer pathogenesis
Bhattacharjee B, Mandal N, Roy S, Sengupta S. Characterization of sequence variations within HPV16 isolates among Indian women: Prediction of causal role of rare non-synonymous variations within intact isolates in cervical cancer pathogenesis. Virology 2008, 377: 143-150. PMID: 18495198, DOI: 10.1016/j.virol.2008.04.007.Peer-Reviewed Original ResearchConceptsNon-synonymous changesCharacterization of sequence variationsPolymorphic variationDeleterious to protein functionHPV16 isolatesNon-synonymous variationsRare non-synonymous variationsDeleterious variationHaplotype backgroundNucleotide variationsSIFTS databaseDeleterious mutationsSequence variationSequence variantsProtein functionHPV16 genomeHaplotype analysisHaplotypesFunctional validationCervical cancer pathogenesisE-12IsolatesCaCx developmentCancer pathogenesisProductive infection
2006
CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2
Bhattacharjee B, Sengupta S. CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 2006, 354: 280-285. PMID: 16905170, DOI: 10.1016/j.virol.2006.06.018.Peer-Reviewed Original ResearchConceptsLong control regionE2 binding sitesP97 promoterCervical cancerNormal controlsAssociated with cervical cancerCytologically normal controlsIntact E2 geneHuman papillomavirus type 16Binding sitesMspI restriction digestionRegulate transcriptionRepressor activityHPV-16CaCx samplesCpG methylationControl regionIntact E2Restriction digestionE7 genesType 16E2 geneCaCxMalignant samplesSite methylation