$15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger
Principal Investigators Serena Spudich, MD, MA (Neurology), Mark Gerstein, PhD (Molecular Biophysics and Biochemistry), and Yuval Kluger, PhD (Pathology) were recently awarded a $15 million grant from the National Institute on Drug Abuse (NIDA) to establish a Data Center to coordinate, analyze, and make accessible single-cell and other molecular data sets generated by Single-Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.
Yale's Human Genomics Efforts Get a New Boost
Under its incoming director, Ira M. Hall, PhD, the Yale Center for Genomic Health will have goals that include creating and leading studies of human genome variation and disease; enhancing the university’s abilities in computational genomics, bioinformatics, and data science; and leading efforts at Yale to implement genomics in health care.
A Winning Team at Startup Yale Includes Two School of Medicine PhD Candidates
Guannan Gong and Feimei Liu participated in the CtrlTrial group that developed a prototype for automating and improving the process of patient identification for clinical trials by applying data science and artificial intelligence technologies both to clinical trial protocols and to patients’ electronic medical records.
Geneticist Sidi Chen Receives Large Award Which Will Further His Breast Cancer Work
This Department of Defense award goes to the “best and brightest in their fields,” and recognizes “creative and innovative individuals.” Investigators are chosen for their ability “to go beyond conventional thinking” in their respective areas of expertise.
"Introduction to Biomedical Data Science and Health Informatics" Summer Course, June 8-12, Will Be Online
A one-week online summer course to offer basic biomedical data science knowledge and health informatics skills. Each day will consist of office hours and labs. Lectures will be distributed in advance.
Cardiologist Creates Podcast to Encourage Patients to Become More Involved in Health Care Decisions
Harlan Krumholz, MD, had been a cardiologist and professor of social and policy studies at Yale School of Medicine for years when Claudine Litman, a former designer and student, introduced him to Charles and Ray Eames’ philosophy for making iconic furniture: Never delegate understanding.Source: Stanford Medicine
Nature Biotechnology "Visualizing structure and transitions in high-dimensional biological data" - Krishnaswamy Lab
The high-dimensional data created by high-throughput technologies require visualization tools that reveal data structure and patterns in an intuitive form. We present PHATE, a visualization method that captures both local and global nonlinear structure using an information-geometric distance between data points.Source: Nature Biotechnology
Yale Scientists Help Immune System Find Hidden Cancer Cells
Cancer cells are masters at avoiding detection, but a new system developed by Yale Cancer Center scientists can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss, the researchers report Oct. 14 in the journal Nature Immunology.
Midsummer Course Sharpens Skills in Informatics and Data Science
The Center for Biomedical Data Science (CBDS), in conjunction with Yale Center for Medical Informatics (YCMI), has held its first midsummer course, “Introduction to Informatics and Data Science in the Clinical Health and Biomedical Context.” It was five concentrated days on the Yale West Campus,
Three-day Workshop Oct. 16-18: "Machine Learning for Single-cell Analysis"
The Center for Biomedical Data Science and the Krishnaswamy Laboratory, along with the Yale Center for Genome Analysis are presenting a three day workshop on “Machine Learning for Single Cell Analysis.” The course will take place October 16-18 in the TEAL Classroom at 17 Hillhouse Avenue, 9:00 to 5:00 each day.
A Better Way to Classify Young Women’s Heart Attacks
A new study, sponsored by Women’s Health Research at Yale, shows how a sex-specific classification system can define and group types of heart attacks that are more common for women. In doing so, the researchers have produced a more accurate guide to treatment and prognosis.
Text Messages Show Promise as Next Step for Improving Heart Health in China
Motivational text messages are a well-liked, feasible new way to provide additional support to Chinese patients with heart disease, reports a preliminary study by researchers at Yale and in China. However, the study did not prove that these targeted text messages led to an improvement in blood pressure control amongst the recipients, the intended outcome.
New Tool Helps Find Genetic Culprits in Cancer’s Spread
The ability of cancer to establish itself in distant parts of the body — called metastasis — causes 90% of deaths from solid tumors. Metastasis is the result of complex genetic interactions that have proven difficult for scientists to study. Now Yale researchers have devised a way to identify some of the most dangerous of those interactions.
New Center to Harness Burgeoning Data
The Center for Biomedical Data Science (CBDS) is one part clearinghouse for the newest data-related ideas; one part incubator for ways to educate students, trainees, and faculty on what data can offer; and one part an innovator of data techniques to advance biomedical science and data science. As CBDS matures, additional pursuits are sure to follow.Source: Medicine@Yale
Yale scientists identify cancer-suppressing gene in mice
Remove just one gene in a cell and it can cause rapid, uncontrollable cell division — cancer. Animal immune systems have developed their own kind of police force to keep tumors in check. But what if a single gene, when deleted, could have the ability to stop even the most competent of immune systems from killing cancerous cells? According to a recent study by researchers at the Yale Systems Biology Institute, the gene exists, and it has a name: Prkar1a. Located on the bottom half of chromosome 11 in mice, Prkar1a codes for a protein that aids in the cell signal pathway. But when the team injected cells without the gene under the skin of mice, those cells rapidly grew into tumors that were able to evade normal immune responses. A gene like this is not new in itself — plenty of other genes are linked to cancer, such as Csnk1a1, Nf2 and Zbtb40 — but there’s more than meets the microscope with Prkar1a.Source: Yale Daily News