Yale Researchers Identify Tumor Reactive Immune Cells to Help Fight Against Advanced Melanoma
According to a new study led by Yale Cancer Center and Department of Neurology researchers, a simple blood draw may be the first step in helping to discover tumor reactive immune or T cells to treat advanced melanoma, a deadly form of skin cancer.
'Cellular Chatter': Researchers Aim to Decode Communications Within a Tumor
Inside a tumor, chatter abounds. Multiple cell types are constantly communicating with each other, exchanging various types of information. Some are working together against the tumor, while others help the tumor grow. Researchers have a good handle on who the main players are, but it can be difficult to tell the good ones from the bad ones, and who’s communicating with whom. To make things even more complicated, sometimes good cells turn bad — and researchers don’t know why.
Microbiology Society Honors Steitz with Its 2021 Prize Medal
The Microbiology Society, based in the United Kingdom and the largest such society in Europe, is presenting its 2021 Prize Medal to Joan A. Steitz, PhD, Sterling Professor of Molecular Biophysics and Biochemistry and Howard Hughes Medical Institute Investigator.
$15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger
Principal Investigators Serena Spudich, MD, MA (Neurology), Mark Gerstein, PhD (Molecular Biophysics and Biochemistry), and Yuval Kluger, PhD (Pathology) were recently awarded a $15 million grant from the National Institute on Drug Abuse (NIDA) to establish a Data Center to coordinate, analyze, and make accessible single-cell and other molecular data sets generated by Single-Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.
Yale's Human Genomics Efforts Get a New Boost
Under its incoming director, Ira M. Hall, PhD, the Yale Center for Genomic Health will have goals that include creating and leading studies of human genome variation and disease; enhancing the university’s abilities in computational genomics, bioinformatics, and data science; and leading efforts at Yale to implement genomics in health care.
A Winning Team at Startup Yale Includes Two School of Medicine PhD Candidates
Guannan Gong and Feimei Liu participated in the CtrlTrial group that developed a prototype for automating and improving the process of patient identification for clinical trials by applying data science and artificial intelligence technologies both to clinical trial protocols and to patients’ electronic medical records.
Geneticist Sidi Chen Receives Large Award Which Will Further His Breast Cancer Work
This Department of Defense award goes to the “best and brightest in their fields,” and recognizes “creative and innovative individuals.” Investigators are chosen for their ability “to go beyond conventional thinking” in their respective areas of expertise.
"Introduction to Biomedical Data Science and Health Informatics" Summer Course, June 8-12, Will Be Online
A one-week online summer course to offer basic biomedical data science knowledge and health informatics skills. Each day will consist of office hours and labs. Lectures will be distributed in advance.
Cardiologist Creates Podcast to Encourage Patients to Become More Involved in Health Care Decisions
Harlan Krumholz, MD, had been a cardiologist and professor of social and policy studies at Yale School of Medicine for years when Claudine Litman, a former designer and student, introduced him to Charles and Ray Eames’ philosophy for making iconic furniture: Never delegate understanding.Source: Stanford Medicine
Nature Biotechnology "Visualizing structure and transitions in high-dimensional biological data" - Krishnaswamy Lab
The high-dimensional data created by high-throughput technologies require visualization tools that reveal data structure and patterns in an intuitive form. We present PHATE, a visualization method that captures both local and global nonlinear structure using an information-geometric distance between data points.Source: Nature Biotechnology
Yale Scientists Help Immune System Find Hidden Cancer Cells
Cancer cells are masters at avoiding detection, but a new system developed by Yale Cancer Center scientists can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss, the researchers report Oct. 14 in the journal Nature Immunology.
Yale Launches Comprehensive DNA Sequencing Project, With Aim of Predicting, Preventing, and Treating Gene-related Diseases
Generations, a collaboration between Yale School of Medicine and Yale New Haven Health System, is one of the largest DNA sequencing projects of its kind in the United States.
A Better Way to Classify Young Women’s Heart Attacks
A new study, sponsored by Women’s Health Research at Yale, shows how a sex-specific classification system can define and group types of heart attacks that are more common for women. In doing so, the researchers have produced a more accurate guide to treatment and prognosis.
Text Messages Show Promise as Next Step for Improving Heart Health in China
Motivational text messages are a well-liked, feasible new way to provide additional support to Chinese patients with heart disease, reports a preliminary study by researchers at Yale and in China. However, the study did not prove that these targeted text messages led to an improvement in blood pressure control amongst the recipients, the intended outcome.