Nature Biotechnology "Visualizing structure and transitions in high-dimensional biological data" - Krishnaswamy Lab
The high-dimensional data created by high-throughput technologies require visualization tools that reveal data structure and patterns in an intuitive form. We present PHATE, a visualization method that captures both local and global nonlinear structure using an information-geometric distance between data points.
Yale Scientists Help Immune System Find Hidden Cancer Cells
Cancer cells are masters at avoiding detection, but a new system developed by Yale Cancer Center scientists can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss, the researchers report Oct. 14 in the journal Nature Immunology.
Midsummer Course Sharpens Skills in Informatics and Data Science
The Center for Biomedical Data Science (CBDS), in conjunction with Yale Center for Medical Informatics (YCMI), has held its first midsummer course, “Introduction to Informatics and Data Science in the Clinical Health and Biomedical Context.” It was five concentrated days on the Yale West Campus,
Three-day Workshop Oct. 16-18: "Machine Learning for Single-cell Analysis"
The Center for Biomedical Data Science and the Krishnaswamy Laboratory, along with the Yale Center for Genome Analysis are presenting a three day workshop on “Machine Learning for Single Cell Analysis.” The course will take place October 16-18 in the TEAL Classroom at 17 Hillhouse Avenue, 9:00 to 5:00 each day.
A Better Way to Classify Young Women’s Heart Attacks
A new study, sponsored by Women’s Health Research at Yale, shows how a sex-specific classification system can define and group types of heart attacks that are more common for women. In doing so, the researchers have produced a more accurate guide to treatment and prognosis.
Text Messages Show Promise as Next Step for Improving Heart Health in China
Motivational text messages are a well-liked, feasible new way to provide additional support to Chinese patients with heart disease, reports a preliminary study by researchers at Yale and in China. However, the study did not prove that these targeted text messages led to an improvement in blood pressure control amongst the recipients, the intended outcome.
New Tool Helps Find Genetic Culprits in Cancer’s Spread
The ability of cancer to establish itself in distant parts of the body — called metastasis — causes 90% of deaths from solid tumors. Metastasis is the result of complex genetic interactions that have proven difficult for scientists to study. Now Yale researchers have devised a way to identify some of the most dangerous of those interactions.
New Center to Harness Burgeoning Data
The Center for Biomedical Data Science (CBDS) is one part clearinghouse for the newest data-related ideas; one part incubator for ways to educate students, trainees, and faculty on what data can offer; and one part an innovator of data techniques to advance biomedical science and data science. As CBDS matures, additional pursuits are sure to follow.
Yale scientists identify cancer-suppressing gene in mice
Remove just one gene in a cell and it can cause rapid, uncontrollable cell division — cancer. Animal immune systems have developed their own kind of police force to keep tumors in check. But what if a single gene, when deleted, could have the ability to stop even the most competent of immune systems from killing cancerous cells? According to a recent study by researchers at the Yale Systems Biology Institute, the gene exists, and it has a name: Prkar1a. Located on the bottom half of chromosome 11 in mice, Prkar1a codes for a protein that aids in the cell signal pathway. But when the team injected cells without the gene under the skin of mice, those cells rapidly grew into tumors that were able to evade normal immune responses. A gene like this is not new in itself — plenty of other genes are linked to cancer, such as Csnk1a1, Nf2 and Zbtb40 — but there’s more than meets the microscope with Prkar1a.
CBDS Seminar Series Continues April 3 with “Learning the Secrets of Sequences with Deep Generative Models” - CANCELLED
The next talk in the Center for Biomedical Data Science Seminar Series will be Wednesday, April 3, at 4 p.m. in Brady Memorial Auditorium. Deborah S. Marks, PhD, of Harvard Medical School will discuss “Learning the Secrets of Sequences with Deep Generative Models.”
‘Striking’ Improvements in Acute MI Care Over Past 20 Years, Report Shows
There has been a marked reduction in the number of patients hospitalized for acute myocardial infarction, as well as significant improvements in short- and midterm clinical outcomes, over the past 20 years, according to a new analysis of Medicare fee-for-service patients.
Giant Study Suggests Apple Watch Accurately Catches Atrial Fibrillation
Early results from a giant study of Apple Watch users show the wearable device appears to detect atrial fibrillation (AF) with a high degree of accuracy, and about half the users who got an AF alert said they contacted a doctor.
Novel YSPH Framework Helps Identify Genes Associated with Disease
A powerful analytical tool, known as UTMOST, developed by Hongyu Zhao, Ph.D., the Ira V. Hiscock Professor of Biostatistics at the Yale School of Public Health, and colleagues could allow researchers to design therapeutic drugs that more effectively combat disease.
Big Data: Balancing Privacy and Innovation
Often cited as the "4th Industrial Revolution" big data has the potential to transform health and healthcare by drawing medical conclusions from new and exciting sources such as electronic health records, genomic databases, and even credit card activity. In this podcast you will hear from tech, healthcare, and regulatory experts on potential paths forward that balance privacy and consumer protections while fostering innovations that could benefit everyone in our society.
Protection from Zika Virus May Lie in a Protein Derived from Mosquitoes
By targeting a protein found in the saliva of mosquitoes that transmit Zika virus, Yale investigators reduced Zika infection in mice. The finding demonstrates how researchers might develop a vaccine against Zika and similar mosquito-borne viruses, the study authors said.