2024
Impact of Procedure Time on First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke
Koo A, Reeves B, Renedo D, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Arthur A, Yoshimura S, Cuellar H, Grossberg J, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Park M, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, Spiotta A, Sheth K, de Havenon A, Matouk C. Impact of Procedure Time on First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke. Neurosurgery 2024, 95: 128-136. PMID: 38483158, DOI: 10.1227/neu.0000000000002900.Peer-Reviewed Original ResearchAnterior circulation large vessel occlusion acute ischemic strokeAcute ischemic strokeLarge vessel occlusion acute ischemic strokeProcedure timeMechanical thrombectomyExcellent reperfusionClinical benefitIschemic strokeAnterior circulation acute ischemic strokeSuccess of mechanical thrombectomyModified Rankin Scale scoreRankin Scale scoreLogistic regression modelsNo significant differencePrimary study exposuresPrimary outcomeFunctional outcomesPotential confoundersStudy exposureThrombectomy devicesScale scoreThrombectomyReperfusionPatientsSignificant differenceManagement of Incomplete Microcirculatory Reperfusion After Endovascular Thrombectomy: Focus on Inhibition of the Glycoprotein IIb/IIIa Receptor Pathway
Krothapalli N, Ortel T, McBride D, de Havenon A, Sansing L, Hasan D, Mac Grory B. Management of Incomplete Microcirculatory Reperfusion After Endovascular Thrombectomy: Focus on Inhibition of the Glycoprotein IIb/IIIa Receptor Pathway. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001048.Peer-Reviewed Original ResearchMicrocirculatory reperfusionEndovascular thrombectomyAdministration of tirofibanDigital subtraction angiographyLarge-vessel occlusionProportion of casesRescue therapyTherapeutic optionsAntiplatelet therapyClinical outcomesUnfavorable outcomeEndothelial edemaSubtraction angiographyEffective therapyIntraarterial administrationClinical challengeReceptor pathwayPlatelet aggregationTreatment approachesTherapyReperfusionCerebral microvasculatureTissue recoveryNeurological diseasesThrombectomy
2023
Endovascular Therapy for Acute Stroke: New Evidence and Indications
Sahoo A, Abdalkader M, Yamagami H, Huo X, Sun D, Jia B, Weyland C, Diana F, Kaliaev A, Klein P, Bui J, Kasab S, de Havenon A, Zaidat O, Zi W, Yang Q, Michel P, Siegler J, Yaghi S, Hu W, Nguyen T. Endovascular Therapy for Acute Stroke: New Evidence and Indications. Journal Of Neuroendovascular Therapy 2023, 17: 232-242. PMID: 38025253, PMCID: PMC10657733, DOI: 10.5797/jnet.ra.2023-0047.Peer-Reviewed Original ResearchRandomized clinical trialsTreatment of patientsIntravenous thrombolysisEndovascular therapyMechanical thrombectomyClinical trialsAcute ischemic strokeDistal vessel occlusionNon-contrast CTExtended windowOngoing studiesCTA collateralsRescue stentingTandem occlusionsAcute strokeCore infarctIschemic strokeTreatment indicationsCore infarctionVessel occlusionRecent trialsThrombectomyPatientsAdvanced imagingNarrative reviewLarge Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes
de Havenon A, Zaidat O, Amin-Hanjani S, Nguyen T, Bangad A, Abbasi M, Anadani M, Almallouhi E, Chatterjee R, Mazighi M, Mistry E, Yaghi S, Derdeyn C, Hong K, Kvernland A, Leslie-Mazwi T, Al Kasab S. Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes. Stroke 2023, 54: 1695-1705. PMID: 36938708, PMCID: PMC10202848, DOI: 10.1161/strokeaha.122.040008.Peer-Reviewed Original ResearchConceptsLarge vessel occlusion strokeIntracranial atherosclerotic diseaseEndovascular thrombectomyAtherosclerotic diseaseOcclusion strokeFunctional outcome benefitsVascular risk factorsAdjunctive medicationsMedical managementPatient factorsInterventional treatmentOutcome benefitsRisk factorsObservational studyEarly identificationTreatment planningThrombectomyUnique considerationsPatientsStrokeLVODiseaseRevascularizationMedicationsReview
2021
Higher Systolic Blood Pressure Variability After Endovascular Thrombectomy Is Associated with Poor Functional Outcome (2903)
Prasad A, Kobsa J, Kodali S, Nguyen C, Orozco D, Farooqui M, Zevallos C, Gutierrez S, Anadani M, Almallouhi E, Kim J, Maier I, Riou-Comte N, Wolfe S, Brown P, Fargen K, Mistry E, Fakhri H, Mistry A, Wong K, De Havenon A, Nascimento F, Sheth K, Petersen N. Higher Systolic Blood Pressure Variability After Endovascular Thrombectomy Is Associated with Poor Functional Outcome (2903). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2903.Peer-Reviewed Original ResearchElevated Blood Pressure Variability During Transport for Endovascular Thrombectomy is Associated with Worse Functional Outcome (4167)
de Havenon A, Sheibani N, Alexander M, Wong K, Petersen N. Elevated Blood Pressure Variability During Transport for Endovascular Thrombectomy is Associated with Worse Functional Outcome (4167). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.4167.Peer-Reviewed Original ResearchBlood Pressure Management Before, During, and After Endovascular Thrombectomy for Acute Ischemic Stroke
de Havenon A, Petersen N, Sultan-Qurraie A, Alexander M, Yaghi S, Park M, Grandhi R, Mistry E. Blood Pressure Management Before, During, and After Endovascular Thrombectomy for Acute Ischemic Stroke. Seminars In Neurology 2021, 41: 046-053. PMID: 33472269, PMCID: PMC8063274, DOI: 10.1055/s-0040-1722721.Peer-Reviewed Original ResearchConceptsBlood pressure managementEndovascular thrombectomyBlood pressurePressure managementLarge vessel occlusion stroke patientsMaximum systolic blood pressureOptimal blood pressure managementAmerican Heart Association guidelinesAcute ischemic strokeHeart Association guidelinesSystolic blood pressurePenumbral perfusionSuccessful recanalizationIschemic strokeGuideline recommendationsStroke patientsHyperacute phaseAssociation guidelinesPatient outcomesClinical scenariosThrombectomyRecanalizationPatientsHgSpecific evidence
2020
Risk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457)
Nguyen C, Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Peshwe K, de Havenon A, Gilmore E, Sansing L, Schindler J, Matouk C, Sheth K, Petersen N. Risk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4457.Peer-Reviewed Original Research