2024
Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research.
de Havenon A, Ayodele I, Alhanti B, Mac Grory B, Xian Y, Fonarow G, Smith E, Worrall B. Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research. Neurology 2024, 102: e209424. PMID: 38759133, PMCID: PMC11175650, DOI: 10.1212/wnl.0000000000209424.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionNIH Stroke ScaleConsistent with previous studiesAdult acute ischemic stroke patientsCross-sectional cohort analysisAcute ischemic stroke patientsLarge vessel occlusion strokePosterior circulation strokeDiagnosis of ischemic strokeReceiver operating curveNeuroimagingGWTG-StrokeIschemic stroke patientsVascular neuroimagingAdult patientsAtrial fibrillationCirculation strokeCohort analysisClinical covariatesStroke patientsOcclusion strokeVessel occlusionPrevious studiesCut-pointsStroke Scale
2022
Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy
Prasad A, Kobsa J, Kodali S, Bartolome D, Begunova L, Quispe-Orozco D, Farooqui M, Zevallos C, Ortega-Gutiérrez S, Anadani M, Almallouhi E, Spiotta A, Giles J, Keyrouz S, Kim J, Maier I, Liman J, Psychogios M, Riou-Comte N, Richard S, Gory B, Wolfe S, Brown P, Fargen K, Mistry E, Fakhri H, Mistry A, Wong K, Nascimento F, Kan P, de Havenon A, Sheth K, Petersen N. Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy. European Stroke Journal 2022, 7: 365-375. PMID: 36478756, PMCID: PMC9720854, DOI: 10.1177/23969873221106907.Peer-Reviewed Original ResearchBlood pressure variabilitySystolic blood pressure variabilityHigh systolic blood pressure variabilityEndovascular thrombectomyFunctional outcomePressure variabilityHigh blood pressure variabilityLower blood pressure variabilityAcute ischemic stroke patientsLarge vessel occlusion strokePoor discharge outcomeIschemic stroke patientsWorse functional outcomePoor functional outcomeBlood pressure dataHigh trajectory groupGroup-based trajectory modelingHemorrhagic transformationNeurologic outcomeDischarge outcomesSBP trajectoriesStroke patientsOcclusion strokePoor outcomeRelevant confounders2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee
Masoud H, de Havenon A, Castonguay A, Asif K, Nguyen T, Mehta B, Abdalkader M, Gutierrez S, Leslie‐Mazwi T, Mansour O, Ma A, Czap A, Kenmuir C, Sheth S, Novakovic‐White R, Nour M, Jadhav A, Janardhan V, Hassan A, Liebeskind D, Malik A, Zaidat O. 2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000276.Peer-Reviewed Original ResearchSociety of VascularAcute ischemic strokeLarge vessel occlusionIntravenous thrombolysisNeurology guidelinesPractice UpdateIschemic strokeMechanical thrombectomyVessel occlusionClinical trialsLarge vessel occlusion acute ischemic strokeEmergent large vessel occlusionIschemic stroke patientsRecent clinical trialsClass of recommendationRecent clinical dataClinical trial resultsLevel of evidenceClinical trial dataClinical decision makingStroke patientsCombination therapyClinical dataThrombolysisCurrent evidence
2021
Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis
Mac Grory B, Nossek E, Reznik ME, Schrag M, Jayaraman M, McTaggart R, de Havenon A, Yaghi S, Feng W, Furie K, Boyanpally A. Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis. PLOS ONE 2021, 16: e0257697. PMID: 34534252, PMCID: PMC8448368, DOI: 10.1371/journal.pone.0257697.Peer-Reviewed Original ResearchConceptsCarotid artery webCarotid webIschemic stroke patientsCryptogenic strokeComputed tomography angiographyStroke patientsSystematic reviewCohort studyIschemic strokeRelative riskSimilar cohortAcute ischemic stroke patientsCompelling potential mechanismsCryptogenic stroke patientsComprehensive stroke centerAcute ischemic strokeEmbolic ischemic strokeEligible patientsSecondary preventionStroke centersStroke subtypesYounger patientsPooled prevalenceTomography angiographyPatientsBlack Patients with Ischemic Stroke and Hyperglycemia have Worse outcome than Whites if given Intensive Glucose Control
de Havenon A, Muddasani V, Castillo M, Sheth KN, Delic A, Herman A, Conaway M, Johnston KC, Investigators F. Black Patients with Ischemic Stroke and Hyperglycemia have Worse outcome than Whites if given Intensive Glucose Control. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 106065. PMID: 34455151, PMCID: PMC8511272, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106065.Peer-Reviewed Original ResearchConceptsIntensive glucose controlAcute ischemic strokeWorse functional outcomeBlack patientsGlucose controlIschemic strokeWhite patientsExcellent outcomesFunctional outcomeTreatment armsWorse outcomesAcute ischemic stroke patientsStroke Hyperglycemia Insulin Network Effort (SHINE) trialIntensive treatment armStandard treatment armIschemic stroke patientsExcellent functional outcomeMixed effects logistic regression modelsLogistic regression modelsPrimary outcomeStroke patientsPotential confoundersOdds ratioFunctional impairmentPatientsIschaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study
Yaghi S, Henninger N, Giles JA, Guerrero C, Mistry E, Liberman AL, Asad D, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Furie KL, Keyrouz SG, Nouh A, de Havenon A, Khan M, Smith EE, Gurol ME. Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study. Journal Of Neurology Neurosurgery & Psychiatry 2021, 92: 1062-1067. PMID: 33903185, PMCID: PMC8448925, DOI: 10.1136/jnnp-2021-326166.Peer-Reviewed Original ResearchConceptsRecurrent ischemic eventsSymptomatic intracranial hemorrhageIschemic strokeIschemic eventsAtrial fibrillationAnticoagulation therapyAcute cardioembolic strokeAnticoagulation-naïve patientsInitiation of anticoagulationStroke prevention measuresComprehensive stroke centerIschemic stroke patientsAcute ischemic strokeCox regression analysisSecondary prevention strategiesCox hazard modelSICH riskAnticoagulant therapyAnticoagulation statusStroke centersCardioembolic strokeAF patientsConsecutive patientsEarly recurrenceIntracranial hemorrhageDuration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke
de Havenon A, Alexander MD, Nogueira RG, Haussen DC, Castonguay AC, Linfante I, Johnson MA, Nguyen TN, Mokin M, Zaidat OO. Duration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke. Journal Of NeuroInterventional Surgery 2021, 13: 1128-1131. PMID: 33526478, PMCID: PMC8325713, DOI: 10.1136/neurintsurg-2020-016961.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke patientsIschemic stroke patientsSymptomatic strokeSuccessful reperfusionLogistic regression modelsAcute strokeEndovascular therapyStroke patientsLarge vessel occlusive strokeAnterior circulation occlusionCerebral Infarction scoreReal-world cohortLarge vessel occlusionBalloon guide catheterMiddle cerebral arteryIndividual patient dataInternal carotid arteryProbability of reperfusionLower ratesOcclusive strokeEndovascular thrombectomyMechanical thrombectomySecondary outcomesStroke onsetPrimary outcome
2020
Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States
de Havenon A, Ney JP, Callaghan B, Delic A, Hohmann S, Shippey E, Esper GJ, Stulberg E, Tirschwell D, Frontera J, Yaghi S, Anadani M, Majersik JJ. Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105535. PMID: 33310595, PMCID: PMC7832426, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105535.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsIschemic strokeFavorable dischargeStroke patientsPrimary analysisLaboratory-confirmed COVID-19COVID-19Vizient Clinical Data BaseAcute coronary syndromeAcute renal failureCohort of patientsCoronavirus disease 2019Clinical data baseCoronary syndromeHospital deathVenous thromboembolismMechanical thrombectomyRenal failureHispanic patientsDischarge diagnosisSubarachnoid hemorrhageWorse outcomesDisease 2019High riskLower oddsThe Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patientsEndovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes
de Havenon A, Yaghi S, Mistry EA, Delic A, Hohmann S, Shippey E, Stulberg E, Tirschwell D, Frontera JA, Petersen NH, Anadani M. Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes. Journal Of NeuroInterventional Surgery 2020, 12: 1045-1048. PMID: 32989032, PMCID: PMC7523171, DOI: 10.1136/neurintsurg-2020-016777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overBrain IschemiaComorbidityCoronavirus InfectionsCOVID-19Endovascular ProceduresEthnicityFemaleHospital MortalityHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesSex FactorsSocioeconomic FactorsStrokeStroke RehabilitationThrombectomyTreatment OutcomeYoung AdultConceptsCOVID-19 infectionAcute ischemic stroke patientsEndovascular thrombectomyIschemic stroke patientsHospital deathAIS patientsEVT patientsFavorable dischargeStroke patientsLower oddsCOVID-19Intensive care unit lengthLaboratory-confirmed COVID-19Vizient Clinical Data BaseComorbid COVID-19Acute coronary syndromeAcute renal failurePotential adverse eventsICD-10 codesMixed-effects logistic regressionClinical data baseCoronary syndromeLonger hospitalSystemic complicationsAdverse events
2019
Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy
Mistry EA, Mehta T, Mistry A, Arora N, Starosciak AK, De Los Rios La Rosa F, Siegler JE, Chitale R, Anadani M, Yaghi S, Khatri P, de Havenon A. Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy. Stroke 2019, 51: 511-518. PMID: 31813361, PMCID: PMC8010595, DOI: 10.1161/strokeaha.119.027549.Peer-Reviewed Original ResearchConceptsHigh blood pressure variabilityBlood pressure variabilitySystolic blood pressure variabilityEndovascular treatmentPoor outcomeStroke patientsPressure variabilityAnterior circulation acute ischemic stroke patientsLower systolic blood pressure variabilityMeasure of BPVAcute ischemic stroke patientsDiastolic blood pressure variabilityLogistic regressionLarge vessel occlusion strokeMulticenter cohort studyIschemic stroke patientsWorse functional outcomeRate of deathNeurologic outcomeNeurological outcomeCohort studyEndovascular thrombectomyDiastolic BPHighest tertileOcclusion strokeResults From DEFUSE 3
de Havenon A, Mlynash M, Kim-Tenser MA, Lansberg MG, Leslie-Mazwi T, Christensen S, McTaggart RA, Alexander M, Albers G, Broderick J, Marks MP, Heit JJ, Investigators O. Results From DEFUSE 3. Stroke 2019, 50: 632-638. PMID: 30726184, PMCID: PMC6628906, DOI: 10.1161/strokeaha.118.023407.Peer-Reviewed Original ResearchConceptsIschemic core volumeLarge vessel occlusionEndovascular thrombectomyCollateral statusTomography angiographyFunctional independenceDEFUSE 3Poor collateralsLeptomeningeal collateralsStroke patientsVessel occlusionGood collateralsAnterior circulation large vessel occlusionBaseline ischemic core volumeSmall ischemic core volumeAcute ischemic stroke patientsDEFUSE 3 patientsIschemic stroke patientsModified Rankin ScaleStroke-related deathComputed tomography angiographyGood leptomeningeal collateralsTreatment effectsNeurological outcomePrespecified analysisSEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke
Sultan-Qurraie A, Witt T, de Havenon A, Ribo M, Zaidat OO. SEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke. Journal Of NeuroInterventional Surgery 2019, 11: 879. PMID: 30674634, DOI: 10.1136/neurintsurg-2018-014403.Peer-Reviewed Original ResearchConceptsTandem lesionsAcute ischemic stroke patientsCerebral Infarction scoreDistal intracranial occlusionsPost-procedural ThrombolysisIschemic stroke patientsIntracranial arterial occlusionTotal fluoroscopy timeCase-control studyAmount of contrastIntracranial recanalizationEndovascular thrombectomyRecanalization timeArterial punctureIntracranial occlusionArterial occlusionStroke patientsStroke trialsArterial accessConcomitant occlusionDistal lesionsFluoroscopy timeClinical dataProximal vesselsPatientsIncreased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive
de Havenon A, Stoddard G, Saini M, Wong KH, Tirschwell D, Bath P, . Increased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive. JRSM Cardiovascular Disease 2019, 8: 2048004019856496. PMID: 31217966, PMCID: PMC6560789, DOI: 10.1177/2048004019856496.Peer-Reviewed Original ResearchBlood pressure variabilityVirtual International Stroke Trials ArchiveAcute ischemic strokePressure variabilityIschemic strokeStudy enrollmentAcute ischemic stroke patientsDiastolic blood pressure variabilitySystolic blood pressure variabilityIschemic stroke patientsOutcome of deathWorse neurologic outcomeDiastolic blood pressureRisk of deathBlood pressure readingsLogistic regression modelsNeurologic outcomeRankin ScaleStroke onsetBlood pressurePrimary outcomeClinical outcomesStroke patientsRetrospective analysisLarge cohort
2016
Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Wang H, Wold J, Chung L, Tirschwell DL, Majersik JJ. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research And Treatment 2016, 2016: 7670161. PMID: 27974991, PMCID: PMC5126417, DOI: 10.1155/2016/7670161.Peer-Reviewed Original ResearchBlood pressure variabilityLower mean blood pressureSystolic blood pressure variabilityMean blood pressureWorse neurologic outcomeBlood pressureIschemic strokeNeurologic outcomeVessel occlusionPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeAcute ischemic stroke patientsDiastolic blood pressure variabilityProximal vessel occlusionAcute ischemic strokeAnterior circulation strokeIschemic stroke patientsLogistic regression modelsOrdinal logistic regression modelsRankin ScaleAcute settingThrombolytic therapyStroke patientsPatient population
2015
Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram
de Havenon A, Moore A, Sultan-Qurraie A, Majersik JJ, Stoddard G, Tirschwell D. Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram. Translational Stroke Research 2015, 6: 361-364. PMID: 26205844, DOI: 10.1007/s12975-015-0414-x.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsTranscranial DopplerActive malignancyLeft shuntIschemic strokeExtracardiac shuntsStroke patientsPositive transcranial DopplersRecent ischemic strokePercent of patientsComorbid medical conditionsPatent foramen ovalePulmonary arteriovenous malformationsDetection of rightNegative TTEOccult malignancyTOAST classificationCryptogenic strokeStroke subtypesForamen ovaleStandard workupShunt statusArteriovenous malformationsMedical conditionsPatients