2018
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS
Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, Chen R, Blattmann P, Friedrich B, Niméus E, Malander S, Omlin A, Gillessen S, Claassen M, Aebersold R. Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Reports 2018, 23: 2819-2831.e5. PMID: 29847809, DOI: 10.1016/j.celrep.2018.04.114.Peer-Reviewed Original ResearchConceptsN-glycoproteinsAvailable proteomic dataSWATH mass spectrometryImmense clinical interestCancer-type specificProteomic changesProteomic dataN-glycositesProteomic workflowParticular carcinomaProtein compositionClinical stageMetastatic stageBlood samplesPatient plasmaSolid carcinomasEarly cancer detectionSWATH-MSTumor tissueSystemic responseCarcinomaProteinEarly detectionClinical interestCancer
2017
Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues
Faktor J, Sucha R, Paralova V, Liu Y, Bouchal P. Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues. Proteomics 2017, 17 PMID: 27966270, DOI: 10.1002/pmic.201600323.Peer-Reviewed Original ResearchConceptsDifferent clinical-pathological characteristicsClinical pathological characteristicsHuman cancer tissuesClinical studiesCancer tissuesBreast tumorsTumor tissueCoefficient of varianceNumerous conditionsCancer researchMass spectrometry-based proteomic approachMultiple protein analytesProteomic approachTissueSequential window acquisition