2024
Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review
Lacson R, Yu Y, Kuo T, Ohno-Machado L. Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review. Journal Of The American Medical Informatics Association 2024, 31: 1423-1435. PMID: 38726710, PMCID: PMC11105130, DOI: 10.1093/jamia/ocae084.Peer-Reviewed Original ResearchConceptsElectronic health recordsSystematic reviewData sharingMedical data sharingSpeed metricsPreferred Reporting ItemsCertificate storageDecentralized InternetNetwork permissionsBlockchain platformBlockchain applicationsEvaluation metricsBiomedical domainBlockchainBiomedical data managementHealth recordsData managementData storageReporting ItemsHealth sectorQuantitative metricsMedical facilitiesMetricsTrial managementClinical trial management
2023
Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions
Kuo T, Pham A, Edelson M, Kim J, Chan J, Gupta Y, Ohno-Machado L, Anderson D, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bell D, Bernstam E, Ngan C, Day M, Doctor J, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hinske L, Hu Z, Ir D, Jiang X, Kim K, Kim J, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Matheny M, Meeker D, Mou Z, Neumann L, Nguyen N, Nick A, Ohno-Machado L, Park E, Paul P, Pletcher M, Post K, Rieder C, Scherer C, Schilling L, Soares A, SooHoo S, Soysal E, Steven C, Tep B, Toy B, Wang B, Wu Z, Xu H, Yong C, Zheng K, Zhou Y, Zucker R. Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions. Journal Of The American Medical Informatics Association 2023, 30: 1167-1178. PMID: 36916740, PMCID: PMC10198529, DOI: 10.1093/jamia/ocad049.Peer-Reviewed Original ResearchConceptsFederated data analysisUser activity logsSmart contract deploymentRun-time efficiencyData analysis systemData analysis activitiesActivity logsData discoveryQuerying timeBlockchain systemBlockchain technologyNetwork transactionsCOVID-19 data analysisMultiple institutionsLow deploymentBlockchainGitHub repositoryMultiple nodesLarge networksQueriesAnalysis activitiesHigh availabilityLanguage codeBaseline solutionData analysis
2021
Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research
Li M, Kuo T. Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research. International Journal Of Medical Informatics 2021, 156: 104599. PMID: 34628257, PMCID: PMC8479449, DOI: 10.1016/j.ijmedinf.2021.104599.Peer-Reviewed Original ResearchConceptsSharing frameworkPreview featureSoftware consistBlockchain-based frameworkChest X-ray imagesBlockchain networkSoftware inconsistencySmart contractsMerging functionView imagesBlockchainImprove sharingX-ray imagesFrameworkImagesLatencyInteroperabilityImmutabilityNetworkFeaturesData analysisSoftwareCodePreviewDownstream data analysisBenchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track
Kuo T, Bath T, Ma S, Pattengale N, Yang M, Cao Y, Hudson C, Kim J, Post K, Xiong L, Ohno-Machado L. Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track. International Journal Of Medical Informatics 2021, 154: 104559. PMID: 34474309, PMCID: PMC9933142, DOI: 10.1016/j.ijmedinf.2021.104559.Peer-Reviewed Original ResearchConceptsSecure genome analysis competitionData retrieval queriesBlockchain-based methodData sharing methodReal-world problemsQuery indexType of sharingRetrieval queriesBlockchain technologyLedger technologySource codeBlockchain utilizationBlockchain strategyHealthcare applicationsInteraction recordsSharing methodTest datasetSharing recordsBiomedical research applicationsConsortium resourcesNew platformPatient recordsBlockchainQueriesTechnology
2020
iDASH secure genome analysis competition 2018: blockchain genomic data access logging, homomorphic encryption on GWAS, and DNA segment searching
Kuo T, Jiang X, Tang H, Wang X, Bath T, Bu D, Wang L, Harmanci A, Zhang S, Zhi D, Sofia H, Ohno-Machado L. iDASH secure genome analysis competition 2018: blockchain genomic data access logging, homomorphic encryption on GWAS, and DNA segment searching. BMC Medical Genomics 2020, 13: 98. PMID: 32693816, PMCID: PMC7372776, DOI: 10.1186/s12920-020-0715-0.Peer-Reviewed Original ResearchEXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning
Kuo T, Gabriel R, Cidambi K, Ohno-Machado L. EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning. Journal Of The American Medical Informatics Association 2020, 27: 747-756. PMID: 32364235, PMCID: PMC7309256, DOI: 10.1093/jamia/ocaa023.Peer-Reviewed Original ResearchConceptsBlockchain technologyCentral serverServer-based methodBenefits of blockchainData protection policiesCentralized serverArtificial intelligenceModel learningDecentralized approachSmall datasetsBlockchainServerComputation strategySingle pointGeneralizable modelCost of efficiencyGenomic datasetsDatasetDistributed modelTechnologyGenomic dataMultiple institutionsDiscrimination powerIntelligencePotential advantages/disadvantagesComparison of Smart Contract Blockchains for Healthcare Applications.
Yu H, Sun H, Wu D, Kuo T. Comparison of Smart Contract Blockchains for Healthcare Applications. AMIA Annual Symposium Proceedings 2020, 2019: 1266-1275. PMID: 32308924, PMCID: PMC7153130.Peer-Reviewed Original ResearchConceptsHealthcare applicationsSmart contract blockchainHyperledger FabricBlockchain networkHealthcare blockchainHealthcare domainSmart contractsBlockchain technologyBlockchainFeatures of platformsPlatformHyperledgerEthereumImplementationTechnologyApplicationsNetworkHealthcareTutorialPragmatic comparisonPrivacy-preserving model learning on a blockchain network-of-networks
Kuo T, Kim J, Gabriel R. Privacy-preserving model learning on a blockchain network-of-networks. Journal Of The American Medical Informatics Association 2020, 27: 343-354. PMID: 31943009, PMCID: PMC7025358, DOI: 10.1093/jamia/ocz214.Peer-Reviewed Original ResearchConceptsNetwork topologyExecution timeArt methodsPredictive correctnessPrivacy-preserving learningPrivacy-preserving methodsPrivacy-preserving modelSmall training datasetBlockchain networkBlockchain platformBlockchain technologyPrivacy concernsModel learningComplex dataLearning iterationsLearning methodsTraining datasetConsensus algorithmGeneralizable predictive modelsCorrectness resultsModel disseminationHierarchical networkSmall dataHierarchical approachRecord model
2019
Comparison of blockchain platforms: a systematic review and healthcare examples
Kuo T, Rojas H, Ohno-Machado L. Comparison of blockchain platforms: a systematic review and healthcare examples. Journal Of The American Medical Informatics Association 2019, 26: 462-478. PMID: 30907419, PMCID: PMC7787359, DOI: 10.1093/jamia/ocy185.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBlockchain platformPopular blockchain platformsBlockchain applicationsSuitable blockchain platformDifferent blockchain platformsClinical informatics researchersTechnical featuresSoftware engineersHealth informatics applicationsHealthcare applicationsInformatics applicationsHealthcare exampleInformatics researchersPlatformBiomedical research applicationsHealthcareBlockchainImportant technical featuresKey featuresApplicationsResearch applicationsFeaturesBrief introductionTechnologyRequirementsFair compute loads enabled by blockchain: sharing models by alternating client and server roles
Kuo T, Gabriel R, Ohno-Machado L. Fair compute loads enabled by blockchain: sharing models by alternating client and server roles. Journal Of The American Medical Informatics Association 2019, 26: 392-403. PMID: 30892656, PMCID: PMC7787356, DOI: 10.1093/jamia/ocy180.Peer-Reviewed Original Research