2022
Modernizing the NEURON Simulator for Sustainability, Portability, and Performance
Awile O, Kumbhar P, Cornu N, Dura-Bernal S, King JG, Lupton O, Magkanaris I, McDougal RA, Newton AJH, Pereira F, Săvulescu A, Carnevale NT, Lytton WW, Hines ML, Schürmann F. Modernizing the NEURON Simulator for Sustainability, Portability, and Performance. Frontiers In Neuroinformatics 2022, 16: 884046. PMID: 35832575, PMCID: PMC9272742, DOI: 10.3389/fninf.2022.884046.Peer-Reviewed Original ResearchComputer architectureDomain-specific languageCloud platformSoftware distributionScientific workflowsDeveloper baseSource compilerHardware platformTime compilationBuild systemSimulation engineContinuous integrationSimulation platformComputational neuroscienceNew usersNEURON simulatorSimulation performanceBiological modelingUsersPlatformArchitectureWorkflowBetter documentationBackendGPUEfficient Simulation of 3D Reaction-Diffusion in Models of Neurons and Networks
McDougal RA, Conte C, Eggleston L, Newton AJH, Galijasevic H. Efficient Simulation of 3D Reaction-Diffusion in Models of Neurons and Networks. Frontiers In Neuroinformatics 2022, 16: 847108. PMID: 35655652, PMCID: PMC9152282, DOI: 10.3389/fninf.2022.847108.Peer-Reviewed Original ResearchFinite volume method simulationIrregular 3D geometryMethod simulationsDouglas-GunnDimensional simulationsHigh-dimensional simulationsWave curvatureEfficient simulationSimulationsParallel algorithmCylinderModels of neuronsNetwork modelNEURON simulatorReconstruction algorithmRegion of interestAccelerated versionConnected cylindersReaction diffusionReaction-diffusion kineticsElectrophysiological simulationsAlgorithmKinetics
2016
Simulation Neurotechnologies for Advancing Brain Research: Parallelizing Large Networks in NEURON
Lytton WW, Seidenstein AH, Dura-Bernal S, McDougal RA, Schürmann F, Hines ML. Simulation Neurotechnologies for Advancing Brain Research: Parallelizing Large Networks in NEURON. Neural Computation 2016, 28: 2063-2090. PMID: 27557104, PMCID: PMC5295685, DOI: 10.1162/neco_a_00876.Peer-Reviewed Original ResearchConceptsHigh-performance computersLarge networksData management approachNew simulation technologyNeuronal network simulationsTypes of networksSimulation run timeMore big dataNumber of nodesNeuroscience GatewayBig dataData storageNetwork simulationComputational neuroscienceSimulation technologyHybrid networkNEURON simulatorNetwork sizeRun timeNetworkSimulation setupSuch simulationsFire neuronsMajor research initiativeNodes