Reticular Pseudodrusen Status, ARMS2/HTRA1 Genotype, and Geographic Atrophy Enlargement Age-Related Eye Disease Study 2 Report 32
Agrón E, Domalpally A, Cukras C, Clemons T, Chen Q, Swaroop A, Lu Z, Chew E, Keenan T, Groups A. Reticular Pseudodrusen Status, ARMS2/HTRA1 Genotype, and Geographic Atrophy Enlargement Age-Related Eye Disease Study 2 Report 32. Ophthalmology 2022, 130: 488-500. PMID: 36481221, PMCID: PMC10121754, DOI: 10.1016/j.ophtha.2022.11.026.Peer-Reviewed Original ResearchMeSH KeywordsAllelesFluorescein AngiographyGenotypeGeographic AtrophyHigh-Temperature Requirement A Serine Peptidase 1HumansProteinsRetinal DrusenRisk FactorsConceptsARMS2 genotypeCentral maculaAtrophy enlargementRisk allelesHTRA1 risk allelesIndependent risk factorCentral involvementEye Disease StudyFundus autofluorescence imagesGeographic atrophy areaEnlargement rateMixed model regressionAtrophy areaCommercial disclosureRisk factorsFundus photographsAnnual visitsFaster progressionGA progressionGA incidenceDisease StudySimilar findingsAutofluorescence imagesPotential mediationFaster enlargement